Masters Degrees (Pharmaceutical Sciences)
Recent Submissions
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In-silico investigation of CREB-binding protein on castration-resistant prostrate cancer: insight from molecular dynamic simulations and computer aided drug discovery.
(2020)Prostate cancer has evolved over the years despite various treatment and therapy. One recent threat of the prostate cancer is the Castration- Resistant Prostate Cancer (CRPC). The CRPC is an advanced form of prostate cancer. ... -
Evaluation of the pharmacodynamic effects of Ketamine on neurotransmitter levels and CREB/BDNF expression in rat brain.
(2020)Mental disorders contribute to 13% of the global burden of disease. With major depressive disorder (MDD) expected to be the most significant contributor by 2030, the economic and social impact of this burden will be ... -
Formulation of pH-responsive lipid-polymer hybrid nanoparticles for co-delivery and enhanced antibacterial activity of 18β-glycyrrhetinic acid and vancomycin against MRSA.
(2020)Background: Due to the rise in antimicrobial resistance and the challenges accompanied by conventional antibiotic dosage forms, there is a need for developing drug delivery systems that enhance, protect and potentiate the ... -
Evaluation of the use of cannabidiol in the treatment of anxiety related disorders by assessing changes in neurotransmitter levels and expression of CREB/BDNF in the rodent brain.
(2020)Anxiety and anxiety-related disorders are common psychiatric disorders that are responsible for high disease burden. The pathogenesis of anxiety involves dysfunction in the limbic brain regions including the amygdala, ... -
Antimicrobial prescribing in the surgical and medical wards at a private hospital in KwaZulu-Natal.
(2020)Background: Appropriate antimicrobial use is imperative due to the misuse of antimicrobials that has resulted in a growing burden of antimicrobial resistance. Evidence-based guidelines should be adhered to in order to ... -
Molecular modelling approaches in Parkinson’s disease: enhancing Domperidone oral availability through nanopolymers.
(2019)Parkinson’s disease is symbolized by resting tremor, rigidity, and bradykinesia caused by the loss of dopaminergic neurons in the substantia nigra, the presence of Lewy bodies, and a decent response to levodopa. However, ... -
Price, availability and affordability of antineoplastic medicines in Harare’s public and private institutions: implications for access.
(2020)Background: Antineoplastic medicines are increasingly becoming more vital in many public health setups. There has been significant progress made in terms of newer molecules since the advent of chemotherapy. Despite the ... -
Awareness and knowledge of doctors, pharmacists and nurses on adverse drug reaction reporting systems in Namibia.
(2020)Objective Reporting of adverse drug reactions (ADRs) in Namibian public health facilities is routinely done through safety yellow forms which are forwarded to the Therapeutics Information and Pharmacovigilance Centre ... -
The use and safety of antibiotic therapy in pregnant women.
(2020)Background Antibiotic therapy in pregnant women has significantly increased in the effort to reduce maternal and neonatal deaths. However, antibiotic exposure may negatively affect the developing foetus. Information on ... -
Computationally aided direct electrophilic trifluoromethylation and trifluoromethylthiolation via sulfonimidamides.
(2020)Fluorination chemistry is of interest due to fluorine being recognized as a crucial element in pharmaceuticals, and agrochemicals, with 30% of new small molecule drugs incorporating fluorine. The trifluoromethylation and ... -
The safety profile of Vilazodone: a study on post-marketing surveillance.
(2020)Vilazodone was approved in 2011 as an antidepressant to treat major depressive disorder. Like other antidepressants, vilazodone has adverse effects associated with the use of the drug. Being a relatively new drug, it is ... -
Molecular analysis of human immuno-deficiency virus-1 (South African subtype C) protease drug resistance mutations emerging on Darunavir therapy.
(2020)Human immunodeficiency virus as the causative agent of acquired immune deficiency syndrome remains a serious infectious disease and the leading cause of deaths worldwide. According to UNAIDS, approximately 37 million ... -
Comparison of the costs of treating prostate cancer with standard chemotherapy regimens versus targeted nuclear medicines.
(2020)Background: Healthcare costs for the treatment of mCRPC continue to rise year on year. However, with the advent of targeted Nuclear medicine and continued treatment with standard chemotherapy regimen for the treatment ... -
A comparison study between public and private healthcare sector medicine prices in South Africa.
(2020)Introduction The adoption of medicine pricing regulations was established to counter the on-going global struggle of high medicine prices. South Africa’s healthcare is divided into the private and public sector and each ... -
Annual costs incurred on managing adverse drug reactions attributable to fixed-dose combination Highly Active Anti-Retroviral Therapy (HAART) in an outpatient ARV clinic in Gauteng.
(2020)Objective The aim of the study is to identify adverse drug reactions attributable to tenofovir- and zidovudine-based fixed-dose combinations of highly active anti-retroviral therapy and, subsequently, to determine the ... -
Theoretical study on the esterification of methanol with acetic acid and acid halides.
(2015)Esters are a unique class of organic compounds whose production and reactivity are examined in chemical industries and research laboratories throughout the world on a daily basis. An ongoing advancement in esterification ... -
Matching a chelator (DOTA) with ions for radio-pharmaceutical applications using DFT study.
(2016)Organometallic chelators can be potentially used for radiometal-based pharmaceuticals. The bifunctional chelator, which is covalently bound to a lead compound, forms a stable chelator―ion complex to deliver an isotope, as ... -
The impact of the introduction of generics and generic references pricing and candesartan and rosuvastatin utilisation, price and expenditure in South Africa.
(2017)Rationale for the study The growth of pharmaceutical expenditure as a percentage of total health care expenditure has stagnated, both locally and globally, despite increasing consumption. Two factors that contributed ... -
Exploring trends in antibiotic use and resistance in a district, regional and tertiary hospital in the uMgungundlovu District.
(2017)Antibiotics play an important role in overcoming life-threatening bacterial infections. However, the increasing rate of antibiotic resistance is a serious threat to public health. Undoubtedly the indiscriminate use of ...
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