Browsing Doctoral Degrees (Pharmaceutical Sciences) by Title
Now showing items 1-20 of 51
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The antibiotic treatment of gram negative bacteremia-pharmacokinetics and dynamics.
Abstract available in PDF file. -
Beta-lactamase mediated resistance in Escherichia Coli isolated from state hospitals in KwaZulu-Natal.
(2008)Escherichia coli, one of the most common pathogens causing urinary tract infections, has shown increased resistance to commonly used antibiotics. In this study we analyzed the β-lactamase profiles of 38 inhibitor-resistant ... -
Bioavailability studies on various dosage forms of the anorectic, diethylpropion hydrochloride.
(1984)The stereo-chemistry, structure activity relationships and the metabolism of the anorectic drug, diethylpropion hydrochloride, have been reviewed briefly, together with the analytical methods for the determination of this ... -
Combinatorial in-silico modeling and bioinformatics analysis of immune proteins and small-molecular weight inhibitors: a potential for cancer chemotherapy.
(2020)The immune system carries out pivotal functions in the protection of the body from damaging substances, microbes, and cellular alteration that could affect the health of an individual. The component of the immune system ... -
Complexation strategies for the design of novel nano-drug delivery systems to treat bacterial infections caused by superbugs.
(2019)Abstract available in the PDF. -
A computational perspective of influenza a virus targets : neuraminidase and endonuclease.
(2016)Through the ages the viruses have plagued mankind claiming the lives of millions, pre-dating any advancements in the medicinal sciences. One such pathogenic virus is influenza A, which has been implicated in the 1918-Spanish ... -
A Computational perspective on the concerted cleavage mechanism of the natural targets of HIV-1 protease.
(2018)One infectious disease that has had both a profound health and cultural impact on the human race in recent decades is the Acquired Immune Deficiency Syndrome (AIDS) caused by the Human Immunodeficiency Virus (HIV). A ... -
Design of advanced materials and nano delivery approaches for enhancing activity against Methicillin resistant Staphylococcus aureus.
(2018)Infectious diseases, including bacterial infections, continue to be a significant cause of morbidity and mortality globally, antimicrobial resistance has further made them fatal. Limitations of conventional dosage forms ... -
Design, synthesis and pharmacological evaluation of novel fused pyrimidine analogues as anticancer agents.
(2018)Cancer is a multifaceted disease considered as the most serious health burden all over the world. Due to existing of limited anticancer drugs and detrimental side effects, the anticancer research has been challenging. ... -
Design, synthesis and screening of novel PCU-peptide/peptoid derived HIV protease inhibitors.
(2011)The AIDS epidemic in Africa has reached dramatic proportions. Of the 42 million people infected with HIV worldwide, 30 million are in Africa. Current available therapies have begun to transform this fatal disease into a ... -
Design, synthesis and spectral characterization of quinazoline and benzoxazine derivatives as novel DNA gyrase inhibitors.
(2020)Tuberculosis (TB) has remained one of the leading causes of the death worldwide and recently surpassed HIV/AIDS as lethal disease caused by a single infectious agent. Further, development of resistance against frontline ... -
Development of a framework for the standardization of management of diabetes and hypertension: the case of Tswanas and Zulus of South Africa.
(2019)Introduction: In sub-Saharan Africa, available World Health Organization data indicate an increase in the prevalence rate of non-communicable diseases such as diabetes and hypertension. Dwindling economies, rising costs ... -
Diverse computational tools towards the understanding of HIV targets and design of potential drug candidates.
HIV/AIDS still remains to be a challenging epidemic infecting millions of individuals worldwide. The morbidity and mortality rates of HIV-infected patients has been well documented over the years. Despite on-going HIV/AIDS ... -
Evaluating the impact of the change in regulations related to medicine pricing and pharmacy ownership in the private pharmaceutical sector of South Africa.
(2020)One of the imperatives of the post-1994 government was to improve access to medicines and related pharmaceutical services to previously disadvantaged areas. The government implemented multiple strategies to achieve this ... -
Evaluation of the management of HIV/AIDs with diabetes as a comorbid condition in public health facilities in eThekwini Metro of KwaZulu-Natal: defining contributory factors to patient outcomes.
(2020)Introduction HIV/AIDS has remained a huge burden. It is still affecting large population of people globally with mortality of over 35 million people. South Africa is the most affected country. Substantial progress has ... -
Exploring the buccal delivery potential of an antiretroviral drug.
Whilst antiretroviral drugs (ARVs) have significantly improved treatment of Human Immunodeficiency Virus infection and Acquired Immune Deficiency Syndrome (HIV and AIDS), several limitations exist with their oral route ... -
Grapefruit juice ameliorates nephropathy in streptozotocin induced diabetes.
(2012)Background Diabetic Nephropathy (DN) is the leading cause of end stage renal disease and mortality in diabetic patients. Over the years, medicinal plants have been used to manage diabetes and its complications. Metformin, ... -
In silico investigation of hepatitis c virus: a novel perspective into targeted viral inhibition of NS3 helicase, NS 3/4a protease and NS5b RNA dependent RNA polymerase.
(2019)Hepatitis C Virus (HCV) is an escalating global healthcare and economic burden that requires extensive intervention to alleviate its control. Over the years, drug design efforts have produced many anti-HCV drugs; however, ... -
The in silico investigation of pharmacological targets of the zika virus : insights into the structural characteristics of the NS5 and NS3 proteins from atomistic molecular simulations.
(2017)The re-emerging Zika virus has evolved into a catastrophic epidemic during the past year, with an estimated 1.5 million reported cases of Zika infections worldwide, since the 2015 outbreak in Brazil. The virus has received ...