Pharmaceutical Sciences
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In-silico investigation of CREB-binding protein on castration-resistant prostrate cancer: insight from molecular dynamic simulations and computer aided drug discovery.
(2020)Prostate cancer has evolved over the years despite various treatment and therapy. One recent threat of the prostate cancer is the Castration- Resistant Prostate Cancer (CRPC). The CRPC is an advanced form of prostate cancer. ... -
Evaluation of the pharmacodynamic effects of Ketamine on neurotransmitter levels and CREB/BDNF expression in rat brain.
(2020)Mental disorders contribute to 13% of the global burden of disease. With major depressive disorder (MDD) expected to be the most significant contributor by 2030, the economic and social impact of this burden will be ... -
Formulation of pH-responsive lipid-polymer hybrid nanoparticles for co-delivery and enhanced antibacterial activity of 18β-glycyrrhetinic acid and vancomycin against MRSA.
(2020)Background: Due to the rise in antimicrobial resistance and the challenges accompanied by conventional antibiotic dosage forms, there is a need for developing drug delivery systems that enhance, protect and potentiate the ... -
Evaluation of the use of cannabidiol in the treatment of anxiety related disorders by assessing changes in neurotransmitter levels and expression of CREB/BDNF in the rodent brain.
(2020)Anxiety and anxiety-related disorders are common psychiatric disorders that are responsible for high disease burden. The pathogenesis of anxiety involves dysfunction in the limbic brain regions including the amygdala, ... -
Antimicrobial prescribing in the surgical and medical wards at a private hospital in KwaZulu-Natal.
(2020)Background: Appropriate antimicrobial use is imperative due to the misuse of antimicrobials that has resulted in a growing burden of antimicrobial resistance. Evidence-based guidelines should be adhered to in order to ... -
Combinatorial in-silico modeling and bioinformatics analysis of immune proteins and small-molecular weight inhibitors: a potential for cancer chemotherapy.
(2020)The immune system carries out pivotal functions in the protection of the body from damaging substances, microbes, and cellular alteration that could affect the health of an individual. The component of the immune system ... -
The in silico investigation of the perplexity of synergistic duality: inter-molecular mechanisms of communication in Bcr–Abl.
(2019)Due to their important role in normal cellular physiology, protein kinase activity is tightly regulated and their aberrant activation can lead to cancer. Chronic myeloid leukaemia (CML) is a blood cancer described by ... -
Molecular modelling approaches in Parkinson’s disease: enhancing Domperidone oral availability through nanopolymers.
(2019)Parkinson’s disease is symbolized by resting tremor, rigidity, and bradykinesia caused by the loss of dopaminergic neurons in the substantia nigra, the presence of Lewy bodies, and a decent response to levodopa. However, ... -
Price, availability and affordability of antineoplastic medicines in Harare’s public and private institutions: implications for access.
(2020)Background: Antineoplastic medicines are increasingly becoming more vital in many public health setups. There has been significant progress made in terms of newer molecules since the advent of chemotherapy. Despite the ... -
Evaluating the impact of the change in regulations related to medicine pricing and pharmacy ownership in the private pharmaceutical sector of South Africa.
(2020)One of the imperatives of the post-1994 government was to improve access to medicines and related pharmaceutical services to previously disadvantaged areas. The government implemented multiple strategies to achieve this ... -
Awareness and knowledge of doctors, pharmacists and nurses on adverse drug reaction reporting systems in Namibia.
(2020)Objective Reporting of adverse drug reactions (ADRs) in Namibian public health facilities is routinely done through safety yellow forms which are forwarded to the Therapeutics Information and Pharmacovigilance Centre ... -
The use and safety of antibiotic therapy in pregnant women.
(2020)Background Antibiotic therapy in pregnant women has significantly increased in the effort to reduce maternal and neonatal deaths. However, antibiotic exposure may negatively affect the developing foetus. Information on ... -
Design, synthesis and spectral characterization of quinazoline and benzoxazine derivatives as novel DNA gyrase inhibitors.
(2020)Tuberculosis (TB) has remained one of the leading causes of the death worldwide and recently surpassed HIV/AIDS as lethal disease caused by a single infectious agent. Further, development of resistance against frontline ... -
Computationally aided direct electrophilic trifluoromethylation and trifluoromethylthiolation via sulfonimidamides.
(2020)Fluorination chemistry is of interest due to fluorine being recognized as a crucial element in pharmaceuticals, and agrochemicals, with 30% of new small molecule drugs incorporating fluorine. The trifluoromethylation and ... -
The safety profile of Vilazodone: a study on post-marketing surveillance.
(2020)Vilazodone was approved in 2011 as an antidepressant to treat major depressive disorder. Like other antidepressants, vilazodone has adverse effects associated with the use of the drug. Being a relatively new drug, it is ... -
Evaluation of the management of HIV/AIDs with diabetes as a comorbid condition in public health facilities in eThekwini Metro of KwaZulu-Natal: defining contributory factors to patient outcomes.
(2020)Introduction HIV/AIDS has remained a huge burden. It is still affecting large population of people globally with mortality of over 35 million people. South Africa is the most affected country. Substantial progress has ... -
Molecular analysis of human immuno-deficiency virus-1 (South African subtype C) protease drug resistance mutations emerging on Darunavir therapy.
(2020)Human immunodeficiency virus as the causative agent of acquired immune deficiency syndrome remains a serious infectious disease and the leading cause of deaths worldwide. According to UNAIDS, approximately 37 million ... -
Development of a framework for the standardization of management of diabetes and hypertension: the case of Tswanas and Zulus of South Africa.
(2019)Introduction: In sub-Saharan Africa, available World Health Organization data indicate an increase in the prevalence rate of non-communicable diseases such as diabetes and hypertension. Dwindling economies, rising costs ... -
Comparison of the costs of treating prostate cancer with standard chemotherapy regimens versus targeted nuclear medicines.
(2020)Background: Healthcare costs for the treatment of mCRPC continue to rise year on year. However, with the advent of targeted Nuclear medicine and continued treatment with standard chemotherapy regimen for the treatment ...
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