Now showing items 1-3 of 3
Nucleoside reverse transcriptase inhibitors-associated mutations in the RNase H region of HIV-1 isolates in South African adults and children failing highly active antiretroviral therapy.
Background: The South African national treatment program includes NRTIs in both first and second line highly active antiretroviral therapy regimens. Recently, mutations in the RNase H domain have been associated with ...
The role of the protease cleavage sites in viral fitness and drug resistance in HIV-1 subtype C.
There is an increasing number of patients failing second line highly active antiretroviral therapy (AZT, DDI and LPV/r) in South Africa, where HIV-1 subtype C predominates. Mutations at gag cleavage sites (CS) have ...
Effect of highly active antiretroviral therapy (HAART) on HIV-1 tat protein-induced neurotoxicity.
Background: HIV-1-trans-activating (Tat) protein has been associated with development of HIVassociated neurocognitive disorder (HAND). Previous studies have demonstrated that Tat protein causes neurotoxicity through an ...