College of Health Sciences
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Recent Submissions
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The effects of rhoicissus tridentate dichloromethane extract and its bioactive compounds on uterotonic and glucose lowering activity in-vitro.
(2019)Poor myometrial contractility during labour is associated with an extended partuition process that can affect the neonate’s health status. Chronic use of conventional treatments for diabetes mellitus is sometimes associated ... -
Assessment of the liver in an HIV era: clinical, laboratory and radiological abnormalities.
(2020)Background: Liver – related mortality and morbidity are an increasing burden worldwide. Aim: To outline the pattern of liver abnormalities at a tertiary hospital in KwaZulu Natal (KZN), Durban, South Africa, during the ... -
In-silico investigation of CREB-binding protein on castration-resistant prostrate cancer: insight from molecular dynamic simulations and computer aided drug discovery.
(2020)Prostate cancer has evolved over the years despite various treatment and therapy. One recent threat of the prostate cancer is the Castration- Resistant Prostate Cancer (CRPC). The CRPC is an advanced form of prostate cancer. ... -
Evaluation of the pharmacodynamic effects of Ketamine on neurotransmitter levels and CREB/BDNF expression in rat brain.
(2020)Mental disorders contribute to 13% of the global burden of disease. With major depressive disorder (MDD) expected to be the most significant contributor by 2030, the economic and social impact of this burden will be ... -
Formulation of pH-responsive lipid-polymer hybrid nanoparticles for co-delivery and enhanced antibacterial activity of 18β-glycyrrhetinic acid and vancomycin against MRSA.
(2020)Background: Due to the rise in antimicrobial resistance and the challenges accompanied by conventional antibiotic dosage forms, there is a need for developing drug delivery systems that enhance, protect and potentiate the ... -
Evaluation of the use of cannabidiol in the treatment of anxiety related disorders by assessing changes in neurotransmitter levels and expression of CREB/BDNF in the rodent brain.
(2020)Anxiety and anxiety-related disorders are common psychiatric disorders that are responsible for high disease burden. The pathogenesis of anxiety involves dysfunction in the limbic brain regions including the amygdala, ... -
Antimicrobial prescribing in the surgical and medical wards at a private hospital in KwaZulu-Natal.
(2020)Background: Appropriate antimicrobial use is imperative due to the misuse of antimicrobials that has resulted in a growing burden of antimicrobial resistance. Evidence-based guidelines should be adhered to in order to ... -
Combinatorial in-silico modeling and bioinformatics analysis of immune proteins and small-molecular weight inhibitors: a potential for cancer chemotherapy.
(2020)The immune system carries out pivotal functions in the protection of the body from damaging substances, microbes, and cellular alteration that could affect the health of an individual. The component of the immune system ... -
The in silico investigation of the perplexity of synergistic duality: inter-molecular mechanisms of communication in Bcr–Abl.
(2019)Due to their important role in normal cellular physiology, protein kinase activity is tightly regulated and their aberrant activation can lead to cancer. Chronic myeloid leukaemia (CML) is a blood cancer described by ... -
Knowledge, attitudes and practices concerning oral health care among undergraduate students in the Life Sciences Department at the Central University of Technology, Free State.
(2020)Background Problems with oral health can, in many ways, affect the quality of life. Bad oral health can prevent positive feelings from being expressed by students, influencing their social experiences and how they feel ... -
A review of aplastic/hypoplastic anaemia diagnosed on bone marrow samples at the haematology laboratory at National Health Laboratory Service (NHLS), Inkosi Albert Luthuli Central Hospital, Durban, KwaZulu-Natal.
(2019)Aplastic Anaemia (AA) is a bone marrow failure syndrome (BMFS) characterized by bone marrow aplasia and peripheral blood pancytopenia. The presenting symptoms in patients with AA are often those of anaemia, haemorrhage or ... -
Molecular epidemiology of antibiotic-resistant enterococcus spp. from farm to food-production chain in intensive poultry production in KwaZulu-Natal, South Africa.
(2019)Extensive antibiotic use in intensively-farmed poultry exerts selection pressure for the emergence of multidrug-resistant pathogens. The aim of this study was to determine the antibiotic resistance and virulence profiles ... -
The effect of genital tract inflammation on HIV-specific binding antibodies, IgG subclass and isotype transudation.
(2019)Background: Sexual transmission of HIV across the mucosal surface remains the main route of infection in women. There are several biological and immunological predictors that may enhance mucosal HIV susceptibility, especially ... -
Retrospective chart review of surgical management of compound elevated skull fractures.
(2019)Background: Traumatic skull fractures have been traditionally classified into those that involve the base or vault with distinct entities linear or depressed. Compound elevated skull fracture is a newer entity with scanty ... -
Exploring movement of embodied, enacted, and inscribed knowledge through policy consultation: a case study of a mental health policy consultation process in South Africa.
(2018)This study is concerned with the intersection of knowledge and policy in the context of mental health system challenges in a developing country. Its focus is specifically on the way in which different forms of knowledge, ... -
An investigation into the neurochemical and behavioural patterns of C57Bl6 mice exposed to "Sugars" and its constituents.
(2020)“Sugars” is an illicit drug cocktail that is a low-grade mixture of heroin and other opioids. The composition of this cocktail is highly varied as other ingredients are added during its manufacturing process to add bulk ... -
The use of feedback and feed-forward action plans on the development of clinical skills in undergraduate medical students.
(2019)Background: Deliberate practice is a concentrated learning strategy aimed at achieving a defined goal and feedback enables skills and behaviours to be corrected or reinforced for improved patient care. Clinical skills are ... -
Molecular modelling approaches in Parkinson’s disease: enhancing Domperidone oral availability through nanopolymers.
(2019)Parkinson’s disease is symbolized by resting tremor, rigidity, and bradykinesia caused by the loss of dopaminergic neurons in the substantia nigra, the presence of Lewy bodies, and a decent response to levodopa. However, ...