Drug susceptibility testing of second and third line anti-tuberculosis drugs used in the management of extensively drug resistant tuberculosis.
Drug resistant tuberculosis is a major contributor to South Africa’s quadruple burden of disease. Management of this infection in a highly HIV endemic area is a constant challenge. There is a paucity of new anti-tuberculosis agents in the developmental and clinical trial phases to address the problem of extensively-drug resistant tuberculosis (XDR-TB). In an attempt to affect a cure in patients with XDR-TB, it has become necessary to re-introduce previously used anti-tuberculosis drugs, as well as antimicrobial agents designed for treatment of non-tuberculosis infections. Whilst these drugs may have previously been tested and shown efficacy in drug susceptible tuberculosis, their activity in XDR TB strains was not tested before introduction for management of XDR-TB in KwaZulu-Natal, South Africa. Drug susceptibility testing (DST) plays an integral role in the diagnosis and treatment options for tuberculosis. It is able to decrease the burden and spread of resistant tuberculosis. However DSTs methods for second line anti –TB drugs (SLDs) and third line anti-TB drugs (TLDs) have not been standardised. Critical concentrations of these anti-TB drugs remain unknown or vary within and between settings thus further hampering the control of TB.
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Khan, Munira.; Naidoo, Kogieleum. (South African Medical Association., 2011)This case study highlights an unusual manifestation of extrapulmonary tuberculosis (TB) in a person living with HIV, namely mammary TB. Clinicians practising in settings where HIV and TB are endemic need to be aware ...
Jeena, Lisha.; Naidoo, Kogieleum. (International Union against Tuberculosis and Lung Disease., 2016)Abstract available in pdf.
Comparative Proteomics of Activated THP-1 Cells Infected with Mycobacterium tuberculosis Identifies Putative Clearance Biomarkers for Tuberculosis Treatment. Kaewseekhao, Benjawan.; Naranbhai, Vivek.; Roytrakul, Sittiruk.; Namwat, Wises.; Paemanee, Atchara.; Lulitanond, Viraphong.; Chaiprasert, Angkana.; Faksri, Kiatichai. (Kaewseekhao, B., Naranbhai, V., Roytrakul, S., Namwat, W., Paemanee, A., Lulitanond, V., Chaiprasert, A. and Faksri, K. 2015. Comparative Proteomics of Activated THP-1 Cells Infected with Mycobacterium tuberculosis Identifies Putative Clearance Biomarkers for Tuberculosis Treatment. PloS one 10(7), e0134168., 2015)Abstract available in pdf.