Loveday, Marian Patricia.Wallengren, Kristina.Voce, Anna Silvia.Margot, Bruce.Reddy, T.Master, Iqbal.Brust, James C. M.Chaiyachati, K.Padayatchi, Nesri.2013-06-192013-06-1920122012Loveday, M. et al. 2012. Comparing early treatment outcomes of MDR-TB in a decentralised setting with a centralised setting in KwaZulu-Natal, South Africa. Int J Tuberc Lung Dis. 16(2) pp. 209–215.1027-3719http://dx.doi.org/10.5588/ijtld.11.0401.http://hdl.handle.net/10413/9162Setting—In KwaZulu-Natal, South Africa, a TB and HIV endemic setting, prolonged hospitalisation for the treatment of the growing number of MDR-TB patients is not possible or effective. Objective—We compared early treatment outcomes in patients with MDR-TB, with and without HIV co infection, at a central, urban, referral hospital with four decentralised rural sites. Design—This is an operational, prospective cohort study of patients between 1 July 2008 to 30 November 2009, where culture conversion, time-to-culture-conversion, survival and predictors of these outcomes were analysed. Results—Of the 860 patients with MDR-TB, 419 were at the decentralised sites and 441 at the central hospital. Overall, 71% were HIV co-infected.enMultidrug-resistant tuberculosis--Treatment.Multidrug-resistant tuberculosis--KwaZulu-Natal.HIV infections--Complications.Coinfection.Tuberculosis-HIV co-infected patients.Peer reviewed journal article