Dezzutti, Charlene S.Richardson, Barbra Ann.Marrazzo, Jeanne M.Tugetman, Jessica.Ramjee, Gita.Taha, Taha E.Chirenje, Zvavahera Mike.Abdool Karim, Salim Safurdeen.Hillier, Sharon Louise.Herold, Betsy C.2013-07-012013-07-0120122012Dezzutti, C.S. et al. 2012. Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial. J Infect Dis. 206 (12) pp. 1931-1935.0022-1899http://dx.doi.org/10.1093/infdis/jis555http://hdl.handle.net/10413/9241The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HβD-2 (odds ratio [OR], 2.39; P = .005) and greater Escherichia coli bactericidal activity (OR, 1.22; P = .01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P = .02) and may be a biomarker for HIV-1 acquisition.enAIDS (Disease) in women.HPTN 035 trial.Pre-exposure prophylaxis (PrEP)Peer reviewed journal article