Riou, Catherine.Burgers, Wendy A.Mlisana, Koleka Patience.Roederer, Mario.Abdool Karim, Salim Safurdeen.Williamson, Carolyn.Gray, Clive M.Koup, Richard A.2016-11-012016-11-0120142014Riou, C., Burgers, W.A., Mlisana, K., Koup, R.A., Roederer, M., Karim, S.S.A., Williamson, C. and Gray, C.M. 2014. Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point. Journal of virology 88(3), 1819-1824.http://dx.doi.org/10.1128/JVI.02968-13http://hdl.handle.net/10413/13554CAPRISA, 2014.Defining the characteristics of HIV-specific CD8(+) T cell responses that lead to viral control is crucial for vaccine development. We evaluated the differential impact of magnitude, polyfunctional capacity, and specificity of the CD8(+) response at approximately 6 months postinfection on the viral set point at 12 months in a cohort of HIV-infected individuals. High frequencies of Gag and Nef responses endowed with four functions were the best predictors of a low viral set point.enHIV Infections/immunology.HIV-1/genetics.Cohort Studies.Peer reviewed journal article