Now showing items 1-8 of 8
Evaluation of the MTT and MABA assays for rapid screening of the in vitro activity of synthetic chalcones against Mycobacterium tuberculosis.
Background: The chalcone scaffold (1,3-diaryl-2-propen-i-ones) has the advantage of easy chemical modification and has been shown to possess biological activity against a variety of organisms, including a wide range of ...
The isolation of antibiotic survivors in mycobacterium tuberculosis using fluorescence activated cell sorting (FACS).
Abstract available in PDF file.
Microfluidic technologies for genomic interrogation of mycobacterium tuberculosis clinical isolates using the polymerase chain reaction (PCR) and high resolution melting analysis (HRMA).
Background: A number of Mycobacterium tuberculosis (Mtb) genes have been shown to be under positive selection pressure in the presence of anti-TB therapy. This results in the selection of drug resistant phenotypes associated ...
Perceived ethionamide resistance in isoniazid susceptible isolates of mycobacterium tuberculosis.
In Mycobacterium tuberculosis, resistance to ethionamide (ETH) is usually combined with isoniazid (INH) resistance due to a number of mutations in genes that are involved in the biosynthesis of mycolic acids. ETH resistance ...
Differences in the susceptibility of mycobacterium tuberculosis to the 1st and 2nd line antituberculosis drugs under aerobic and anaerobic conditions.
Although Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is now considered a facultative anaerobe, and bacilli isolated from sputum specimen possess morphologies identified from bacilli growing ...
The impact of the introduction of direct first and second-line reflex testing in the management of drug-resistant Tuberculosis at Greytown Hospital, Umzinyathi District, KwaZulu-Natal.
Background Drug resistant tuberculosis (DR-TB) is a serious public health issue both globally and nationally, with South Africa and Kwazulu-Natal, in particular, being among the regions with the highest burden of DR-TB. ...