Browsing Doctoral Degrees (Biochemistry) by Title
Now showing items 50-69 of 74
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Plasmodium yoelii acetyl-coa carboxylase : detection and characterisation of the recombinant biotinoyl domain.
(2008)Human malaria, caused by four species of the intracellular protozoan parasite Plasmodium, is a major health and economic burden in the tropics where the disease is endemic. The biotindependent enzyme acetyl-CoA carboxylase ... -
The presentation and interpretation of arrow symbolism in biology diagrams at secondary-level.
(2006)The literature contains conflicting ideas about the effectiveness of diagrams, and their constituent symbolism as teaching and learning tools. In addition, only limited research has been specifically conducted on the ... -
Properties of Cathepsin L in relation to a role in invasive cancer.
(1998)Cathepsin L, which has been implicated in many tissue degradative pathologies by virtue of its ability to degrade extracellular matrix components, was isolated by a novel, scaled-up protein purification method and purified ... -
Proteinases and extracellular matrix degradation in breast cancer.
(1996)A variety of proteases have been shown to promote the progression of cancer by virtue of their ability to degrade extracellular proteinaceous barriers, such as basement membrane and interstitial stroma. At the outset of ... -
Quantitative imaging of tyrosine kinase-drug interactions in cells.
(2012)Kinases play a crucial role in regulating cellular signaling cascades, making them therapeutic targets for several human diseases. In human cancers, mis-regulation and mutations of kinases such as EGFR (epidermal growth ... -
Receptor targeted gene delivery using folate ligand conjugated cationic liposomes.
(2014)Gene therapy has become an important strategy to treat several human diseases, including cancer, viral infections and inherited disorders. In response to this growing trend, a number of gene delivery vectors have been ... -
Recombinant expression and initial characterisation of two Plasmodium copper binding proteins.
(2011)Plasmodium falciparum is a protozoan parasite responsible for the most severe form of human malaria, with infection often resulting in death. Efforts to control malaria have been hindered by an increased spread of parasite ... -
A serine oligopeptidase from African Trypanosomes.
(1998)Protozoan parasites of the genus Trypanosoma are responsible for chronic and widespread disease in livestock and humans in Africa. This study describes the purification and characterisation of a serine oligopeptidase ... -
Some aspects of development and cell wall properties of the desiccation-sensitive embryos of Encephalartos natalensis (Zamiaceae)
(2013)The present investigation can be divided into two main sections: the first dealing with the post-shedding embryogenesis of Encephalartos natalensis and the second concerned with the cell wall properties of immature and ... -
Some aspects of the role of rat liver ribosomes in protein biosynthesis.
(1969)No abstract available. -
Starburst poly-amidoamine dendrimer grafted gold nanoparticles as scaffolds for targeted gene delivery in vitro.
(2017)Abstract available in PDF file. -
Studies on a multicatalytic, protease complex from Trypanosoma brucei brucei.
(1999)Subcellular fractionation (together with immunocytochemical localisation studies) showed that the parasite Trypanosoma brucei brucei possesses a multicatalytic protease complex (MCPTb). This complex is predominantly ... -
Studies on acid phosphatases of Trypanosoma congolense.
(1997)Bloodstream forms of African trypanosomes, which endocytose macromolecules exclusively through their flagellar pockets, contain an acid phosphatase (AcP) activity in this organelle. In the present thesis, AcP activity ... -
Studies on the anti-hyperglycemic potentials and possible mode of actions of some commonly used sugar alcohols.
(2016)Abstract available in PDF file. -
Studies on the coupling of DNA to low density lipoproteins (LDL) and the interaction of these complexes with eukaryotic cells.
(1987)The application of Molecular Biochemistry for transfection studies in eukaryotic systems is well documented. Of the numerous methods employed for the introduction of foreign DNA into eukaryotic cells, the use of low ... -
Studies on the structural and biological functions of the Cu3 and Cu4 domains of IgM.
(1977)No abstract available. -
A study of proteinases of invasive cells using cryoultramicrotomy and immunogold labelling.
(1993)This study forms part of an investigation into the possible relevance of the lysosomal proteinases, cathepsins B, H, Land D, in cancer cell invasion. In this study, the main technique adopted was the Tokuyasu "cryo" ... -
A study of the African horse sickness virus using High Resolution Melt, multivariate and phylogenetic analyses for a potential serotyping assay.
(2014)African horse sickness (AHS) is a viral disease that afflicts all equine species and has a 90% mortality rate in unvaccinated horses. The disease has a devastating effect on the national herd of South Africa each year ... -
A study of the proteinase, cathepsin L, in the context of tumour invasion.
(1990)The proteinase, cathepsin L, has been strongly implicated in the processes of tumour invasion and metastasis. A new purification method, three-phase partitioning, characterised in terms of the parameters which affected its ...