Browsing Doctoral Degrees (Biochemistry) by Title
Now showing items 36-55 of 73
-
Identification and characterisation of novel pathogenic factors of Trypanosoma congolense.
(2010)Trypanosoma congolense is a major causative agent of the bovine disease trypanosomosis which has a considerable economic impact on sub-Saharan Africa. Current control methods for trypanosomosis are unsatisfactory and ... -
The in vitro and in vivo anti-oxidative and anti-diabetic effects of some African medicinal plants and the identification of the bioactive compounds.
(2013)This thesis examined the in vitro and in vivo anti-oxidative and anti-diabetic activities of five African medicinal plants which are traditionally used for the treatment of diabetes mellitus viz; Ziziphus mucronata, Cassia ... -
An investigation into the analytical, cytotoxicity and immunotoxicity of mycotoxins found in commercially available pelleted pet foods in Durban, South Africa.
(2018)Introduction: Dry pelleted dog food in the South African market is available via supermarket, pet stores (standard brands - SB) and veterinary channels (premium brands-PB). Similarly, cat food were viewed in two market ... -
Investigation of anti-diabetic properties of Psidium guajava leaf in streptozocin induced diabetic rats.
(2015)Diabetes mellitus results in chronic hyperglycaemia, leading to defects in carbohydrate, fat and protein metabolism. Diabetes mellitus is also linked with elevated plasma cholesterol and triglyceride levels, which may ... -
Making sense of mixtures : chromatographic separations of plant, insect and microbial biomolecules.
(1996)No abstract available. -
Mitochondrial localisation and cellular uptake in vitro using novel ‘mitochondriotropic’ liposomes.
(2016)Mitochondrial research has made tremendous strides since the 1980/90s when mitochondrial DNA mutations were first identified as a primary cause for human diseases and the organelle’s role in apoptosis was elucidated. These ... -
Molecular analysis of a Listeria monocytogenes strain that is resistant to leucocin A.
(2000)Leucocin A is a class 11a bacteriocin produced by Leuconostoc mesenteroides TA33a that was previously shown to inhibit Listeria monocytogenes. A spontaneous resistant mutant of L. monocytogenes was isolated, and found ... -
Molecular characterisation of metacaspase 5 and the production of oligopeptidase b-specific single chain variable fragment antibodies for potential animal African trypanosomosis chemotherapies and diagnostics.
(2018)African trypanosomosis (AT) is a major obstacle in the establishment of agriculture and economic sustainability in Africa. Animal AT is responsible for large numbers of livestock succumbing to the tsetse transmitted ... -
Neutrophil tissue inhibitor of matrix metalloproteinases-1 (TIMP- 1) : novel localisation, mobilisation and possible role.
(2002)At the beginning of this study, the granule localisation and regulation of release of human neutrophil (PMNL) precursor collagenases, proMMP-8 and -9 (type I and type TV/V collagenases, respectively), enzymes highly ... -
Novel epidermal growth factor directed cationic lipoplexes promote in vitro hepatotropic gene targeting.
(2014)The need for the improvement in protocols for cellular gene delivery has propelled cytofectin based liposomes as suitable non-viral gene carriers. The amenability of cationic liposomes to modification enables research based ... -
The nutritive value of Italian ryegrass (Lolium multiflorum) selected for high dry matter and nonstructural carbohydrate contents.
(2003)In traditional forage breeding programmes, breeders have spent decades improving the agronomic characteristics of grasses, such as herbage yield, persistence and resistance to diseases, without considering the nutrient ... -
The occurrence of mycotoxins in feedstuffs in Natal and aspects of their metabolism in the rumen.
(1985)The fluorodinitrobenzene (FONB), succinic anhydride (SA), dansyl chloride (DAN), dye-binding lysine (OBL), total lysine (TL), ninhydrin (NIN) and Tetrahymena lysine (TET) methods were compared for their ability to ... -
Plasmodium yoelii acetyl-coa carboxylase : detection and characterisation of the recombinant biotinoyl domain.
(2008)Human malaria, caused by four species of the intracellular protozoan parasite Plasmodium, is a major health and economic burden in the tropics where the disease is endemic. The biotindependent enzyme acetyl-CoA carboxylase ... -
The presentation and interpretation of arrow symbolism in biology diagrams at secondary-level.
(2006)The literature contains conflicting ideas about the effectiveness of diagrams, and their constituent symbolism as teaching and learning tools. In addition, only limited research has been specifically conducted on the ... -
Properties of Cathepsin L in relation to a role in invasive cancer.
(1998)Cathepsin L, which has been implicated in many tissue degradative pathologies by virtue of its ability to degrade extracellular matrix components, was isolated by a novel, scaled-up protein purification method and purified ... -
Proteinases and extracellular matrix degradation in breast cancer.
(1996)A variety of proteases have been shown to promote the progression of cancer by virtue of their ability to degrade extracellular proteinaceous barriers, such as basement membrane and interstitial stroma. At the outset of ... -
Quantitative imaging of tyrosine kinase-drug interactions in cells.
(2012)Kinases play a crucial role in regulating cellular signaling cascades, making them therapeutic targets for several human diseases. In human cancers, mis-regulation and mutations of kinases such as EGFR (epidermal growth ... -
Receptor targeted gene delivery using folate ligand conjugated cationic liposomes.
(2014)Gene therapy has become an important strategy to treat several human diseases, including cancer, viral infections and inherited disorders. In response to this growing trend, a number of gene delivery vectors have been ... -
Recombinant expression and initial characterisation of two Plasmodium copper binding proteins.
(2011)Plasmodium falciparum is a protozoan parasite responsible for the most severe form of human malaria, with infection often resulting in death. Efforts to control malaria have been hindered by an increased spread of parasite ...