Now showing items 111-120 of 123
Development of a novel biochemical assay for the identification of promiscuous compounds.
Promiscuous compounds, specifically aggregate-based inhibitors that result in false positives in biochemical activity assays present a serious and increasing interference to early-stage drug discovery processes. Although ...
Recombinant expression of plasmodium falciparum histidine rich protein-2 (PfHRP-2) and characterisation of chicken anti-PfHRP-2 antibodies.
The diagnosis of malaria using rapid diagnostic tests (RDTs) targets three Plasmodial proteins namely, Plasmodium falciparum histidine rich protein-2 (PfHRP-2); lactate dehydrogenase (LDH) and aldolase. Early diagnosis is ...
Recombinant expression and initial characterisation of two Plasmodium falciparum copper binding proteins: Cox11 and Cox19.
Emerging drug resistance hinders the efforts to control malaria and so novel antimalarial drugs are required. Copper is essential for the survival of plasmodial parasites but the proteins involved in copper homeostasis are ...
Recombinant expression, purification, analysis and immunization of mice with plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase (rPyGAPDH) and lactate dehydrogenase (rPyLDH) and evaluation of protection against P. berghei challenge.
The principal focus in malaria research is the development of an effective malaria vaccine which will help to prevent death and eliminate the disease. This study investigated two plasmodial glycolytic enzymes as possible ...
The evaluation of novel metal -based compounds as potential BACE1 ligands.
The proposed primary cause of Alzheimer’s disease (AD) is the cleavage of the Amyloid-β precursor protein by the β- Amyloid cleavage enzyme 1 (BACE1). As such it has been proposed that inhibiting this enzyme would help ...
Evaluating the effect of nitric oxide on myoblast proliferation, migration and differentiation.
Wound healing is the process of restoring tissue integrity in response to injury. This process involves four major phases namely; haemostasis, inflammation, regeneration and remodelling. These phases are regulated by ...
Mechanisms behind the anti-diabetic effects of caffeine in a Type 2 diabetes model of rats.
Caffeine has been used for many years and is one of the most extensively consumed active food ingredient throughout the world. Caffeine has been broadly studied in a variety of areas regarding human health and performance. ...
Expression and evaluation of a 297-amino acid fragment of the blood stage protein PfC0760c from Plasmodium falciparum.
Abstract available in pdf.
Transferrin receptor-mediated gene delivery using functionalised gold nanoparticles.
Gene therapy strategies have shown their potential in treating numerous central nervous system (CNS) disorders, including highly aggressive brain cancers. Gold nanoparticles (AuNPs) are popular vectors for gene delivery, ...