Browsing Masters Degrees (Biochemistry) by Advisor "Singh, Moganavelli."
Now showing items 1-11 of 11
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The application of layered double hydroxide nanoparticles (LDHs) as potential anticancer drug delivery systems.
(2016)Chemotherapy being one of the principle techniques used in cancer treatment, has been applied in the treatment of a wide spectrum of cancers. However, this mode of treatment is fraught with a myriad of challenges, reducing ... -
Cationic liposome mediated targeted gene delivery with and without pegylated accessories.
(2009)As a consequence of safety issues encountered by the use of viral vectors in gene therapy, there has been a steady increase in the development and application of non-viral vectors, especially liposomes. Cationic liposome ... -
The comparative effects of acetylated and deacetylated galactose derivatives in liposomal gene delivery.
(2014)The use of cationic liposomes remains the most attractive non-viral approach in gene therapy as these gene carriers provide for ease and versatility in design. In targeted gene delivery, liposomes are coupled to ligands ... -
A comparative study on three unique galactosylated cationic liposomes with their steically stablized counterparts, in HepG2 cells.
(2013)Receptor mediated endocytosis allows for the site specific delivery of exogenous DNA via appropriate ligand-receptor interactions. Various ligands have been used to target the asialoglycoprotein receptor (ASGP-R) present ... -
Delivery of Fluc-mRNA using functionalised gold nanoparticles in vitro.
(2016)Nanomedicine, a branch of nanotechnology which includes the use of nanoparticles, is set to revolutionize the area of gene therapy. Gold nanoparticles (AuNPs) have steadily gained favour as promising gene and drug delivery ... -
Effects of catharanthus roseus and centella asiatica leaf extracts on enzymes of glutamine catabolism in human colon carcinoma (CACO-2) cell line and in enterocytes from male sprague-dawley rats.
(2015)Phosphate-dependent glutaminase (PDG) is a key enzyme in several physiological processes and hence has become a target of anti-cancer drug development because of the role of glutamine in providing energy for rapidly dividing ... -
An in vitro assessment of functionalized gold nanoparticles in anticancer drug delivery.
(2017)Abstract available in PDF file. -
A novel in vitro anticancer drug delivery strategy using platinum encapsulated gold nanoparticles.
(2017)Abstract available in PDF file. -
Phytochemistry and anti-cancer potential of compounds isolated from Kenyan medicinal plants, Moringa oleifera and Prunus africana.
(2014)Cancer is one of the leading causes of death worldwide and of all the cancer related deaths occurring worldwide, 70% are in low and middle income countries. In Africa, the disease kills more people than HIV, TB and malaria ... -
Transferrin receptor-mediated gene delivery using functionalised gold nanoparticles.
(2018)Gene therapy strategies have shown their potential in treating numerous central nervous system (CNS) disorders, including highly aggressive brain cancers. Gold nanoparticles (AuNPs) are popular vectors for gene delivery, ... -
The use of cholesterol-galacto compounds in liver directed gene delivery.
(2014)Gene therapy has to date gained immense interest as a potential method for treating genetic disorders such as Parkinson’s and cystic fibrosis. The liver being a central organ of metabolism is susceptible to several ...