Browsing Masters Degrees (Biochemistry) by Title
Now showing items 65-84 of 125
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Induction of autoantibodies to cathepsin L as a step towards an anti-cancer vaccine.
(2005)Cancer is a disease that is caused by mutations in somatic cells. Metastasis is the major cause of death from cancer and often complicates treatment. Malignant tumours secrete degradative enzymes such as cathepsin L which ... -
Infectious bursal disease virus receptor identification with anti-peptide antibodies.
(2004)Infectious bursal disease virus (IBDV) has a tropism for the lymphoid tissue of poultry and infects actively dividing and differentiating B-lymphocytes in the bursa of Fabricius. This results in a high mortality rate and ... -
The influence of ionic strength on the kinetics of selected enzymes.
(2005)pH studies are used to gain insight into chemical mechanisms of enzyme catalysed reactions. However, perhaps the most important practical point that is often overlooked in pH studies is control of the ionic strength of ... -
Investigation into the major surface proteases of African trypanosomes.
(2016)The unicellular parasite of the genus Trypanosoma infects a number of mammalian species including livestock and humans. In sub-Saharan Africa three main parasitic species cause disease: Trypanosoma brucei, T. congolense ... -
An investigation into the proteolytic degradation of antimicrobial peptides by plant extracts and localisation of pleurocidin in transgenic saccharum hybrid species.
(2001)Two cationic antimicrobial peptides, ESF I-GR7, and pleurocidin, were assessed for their stability in plant intercellular fluid, the targeted locale for their expression in transgenic plants. Incubation of ESFI-GR7 and ... -
Investigation of chlorophyll and stomatal chloroplast content in diploid and tetraploid black wattle (Acacia mearnsii de Wild).
(2004)Black wattle (Acacia mearnsii) is one of South Africa's leading commercial exotic species comprising nearly seven percent of South African forestry plantations. The planting of black wattle has become increasingly popular, ... -
Investigation of the molecular adjuvant potential of Trypanosoma congolense BiP/HSP70 using congopain as model antigen.
(2011)African animal trypanosomiasis is a major threat to African agriculture causing a loss estimated to 4.5 billion US$ per annum. Trypanosoma congolense is the major causative agent in African animal trypanosomiasis and is ... -
Killing of mycobacteria by macrophage cathepsin D.
(2011)Tuberculosis (TB) is the fifth largest cause of death in South Africa, with one in ten cases being resistant to treatment due to the development of multidrug-resistance and extensively drug-resistance in the agent responsible ... -
Location and partial purification of phosphate dependent glutaminase from rat small intestine.
(2014)Phosphate dependent glutaminase (PDG) is a key enzyme in intestinal energy metabolism and hence has an impact on nutrient absorption and nutritional status of the whole animal. PDG is known to be a mitochondrial enzyme but ... -
The measurement of glomerular basement membrane components and glycated albumin as improved markers of incipient diabetic nephropathy.
(2010)Diabetes causes early structural changes to the glomerular basement membrane (GBM), which alters its function and leads to loss of protein in urine. Formation of advanced glycation endproducts (AGEs) is one mechanism ... -
Mechanisms behind the anti-diabetic effects of caffeine in a Type 2 diabetes model of rats.
(2018)Caffeine has been used for many years and is one of the most extensively consumed active food ingredient throughout the world. Caffeine has been broadly studied in a variety of areas regarding human health and performance. ... -
Membrane permeability of HIV-1 protease inhibitors.
(2014)According to the 2012 UNAIDS global report, sub-Saharan Africa hosts 69% of the world’s total population living with HIV, South Africa being the most affected with a reported 24% incidence rate. To date, extensive research ... -
Membrane type I metalloproteinase (mt1-mmp) as a target in cancer : a study of two inhibitors.
(2013)Several diseases, including cancer, have been associated with high membrane type-1 matrix metalloproteinase (MT1-MMP) expression levels. MT1-MMP together with a non-membrane-bound, soluble MMP, MMP-2, also associated with ... -
Membrane type-1 matrix metalloproteinase (MT1-MMP) as a target in cancer therapy.
(2007)Membrane type I-matrix metalloproteinase (MT1-MMP), a member of the highly active extracellular matrix (ECM)-degrading matrix metalloproteinases (MMPs), is known to be involved in connective tissue remodelling and ... -
Methods for serological and PCR detection of Salmonella enteritidis in chickens.
(2003)Salmonella enteritidis (S. enteritidis) is a bacterial pathogen of chickens, and is currently one of the leading causes of human food poisoning in the world. It is believed that contaminated poultry products, especially ... -
Methods for serotype classification of Haemophilus paragallinarum field isolates.
(1998)Historically, the causative agent of infectious coryza has been identified as the NAD requiring bacterium Haemophilus paragallinarum and the implementation of an intensive vaccination program led to the effective control ... -
Microbial and physico-chemical quality of some surface water resources in Durban, South Africa.
(2010)Microbial and chemical contamination of inland and coastal waters in Southern Africa is a major challenge facing the water industry and regulatory authorities. Increased stresses on these surface water resources through ... -
Microbiology honours students' conceptual development during a beer brewing teaching learning sequence (TLS)
(2010)Brewing is defined as “the combined processes of preparing beverages from the infusion of sound grains that have undergone sprouting, and the subsequent fermentation of the sugary solution produced, by yeast-whereby a ... -
Molecular analysis of the congopain gene family.
(2008)Animal trypanosomosis is a major constraint in livestock production in Sub-Saharan Africa. With the emergence of resistance against trypanocidal drugs, the cost and environmental concerns raised by vector control, and the ... -
Molecular cloning, recombinant expression and characterisation of serine and cysteine protease inhibitors from Trichinella zimbabwensis.
(2019)Trichinellosis is a disease caused by parasitic helminths of the genus Trichinella. Infection occurs by ingestion of meat contaminated with infective Trichinella larvae. Cases of Trichinella zimbabwensis, a non-encapsulating ...