Browsing Masters Degrees (Biochemistry) by Title
Now showing items 21-40 of 111
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Cloning of the promoter regions of Trypanosoma brucei and Trypanosoma congolense cysteine protease genes.
(1997)Trypanosoma brucei and T. congolense are protozoan parasites that infect humans, domestic livestock and wildlife in Africa. These parasites undergo complex morphological and biochemical changes, during the various stages ... -
The comparative effects of acetylated and deacetylated galactose derivatives in liposomal gene delivery.
(2014)The use of cationic liposomes remains the most attractive non-viral approach in gene therapy as these gene carriers provide for ease and versatility in design. In targeted gene delivery, liposomes are coupled to ligands ... -
A comparative study on three unique galactosylated cationic liposomes with their steically stablized counterparts, in HepG2 cells.
(2013)Receptor mediated endocytosis allows for the site specific delivery of exogenous DNA via appropriate ligand-receptor interactions. Various ligands have been used to target the asialoglycoprotein receptor (ASGP-R) present ... -
Constitutive over-expression of FL01 encoded mannoproteins.
(2014)The ability of yeast cell wall-derived mannoproteins (glycoproteins) to positively contribute to oenological properties has been a key factor that stimulates research initiatives into these industrially important glycoproteins. ... -
Coupling dyes to chicken IgY antibodies for the development of immunodiagnostic tests.
(2003)The aim of this study was to develop a highly simplified, sensitive and specific malarial diagnostic test at the lowest possible cost. Initial work and optimisation of procedures was achieved with chicken antibodies by ... -
A critical analysis of research done to identify conceptual difficulties in acid-base chemistry.
(2009)The literature review shows that student alternative conceptions or misconceptions are important for teaching and learning. Causes of such student difficulties may include the counter-intuitive nature of some chemistry ... -
Delivery of Fluc-mRNA using functionalised gold nanoparticles in vitro.
(2016)Nanomedicine, a branch of nanotechnology which includes the use of nanoparticles, is set to revolutionize the area of gene therapy. Gold nanoparticles (AuNPs) have steadily gained favour as promising gene and drug delivery ... -
The detection of two plasmodium falciparum metabolic enzymes using chicken antibodies.
(2012)Three protein targets are used in malaria rapid diagnostic tests (RDTs). These are Plasmodium falciparum histidine rich protein 2, Plasmodium lactate dehydrogenase and aldolase. A thrust of research in RDTs is to improve ... -
Development of a taxonomy for visual literacy in the molecular life sciences.
(2007)The use of external representations (ERs) such as diagrams and animations in science education, particularly in the Molecular Life Sciences (MLS), has rapidly increased over the past decades. Research shows that ERs have ... -
Development of an alternative non-obese non-genetic rat model of type 2 diabetes using caffeine and streptozotocin.
(2013)The aim of the present study was to develop an alternative non-obese non-genetic rat model of type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats were randomly divided into six groups, namely: Normal Control (NC), ... -
Development of computer models of different selection strategies on poultry egg production.
(2003)Poultry have many behavioural, structural and biological features that are ideal for domestication and for meat and egg production (Appleby et al., 1992). Because of the importance of poultry meat and eggs to the human ... -
Dye-protein interactions : protein staining and dye-IgY, dye-dextran-IgY complexes for antigen detection.
(2004)In order to develop a cheaper alternative to the conventional enzyme-linked immunosorbent assay system, application of dye molecules as labels in immunoassay was investigated in this study. This chromogenic dye-antibody ... -
The effect of antiretrovirals on myoblast proliferation : migration and differentation.
(2013)Successful antiretroviral (ARV) treatment is associated with suppression of HIV viral load and the reduction of clinical disease progression. Despite marked improvements in ARV medication, side effects from long-term ... -
The effect of plant-derived oleanolic acid on selected markers of lipid metabolism and insulin signalling pathway in streptozotocin-induced diabetic rats.
(2013)Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia; this condition is caused by lack of insulin secretion (Type 1) and/or insulin resistance (Type 2). In diabetic patients; carbohydrate, ... -
The effect of Wnt isoforms on myogenesis.
(2014)Satellite cells are muscle stem cells that are responsible for the growth and repair of skeletal muscle tissue. Satellite cells typically exist in a quiescent state in their niche between the sarcolemma and basal lamina. ... -
Effects of catharanthus roseus and centella asiatica leaf extracts on enzymes of glutamine catabolism in human colon carcinoma (CACO-2) cell line and in enterocytes from male sprague-dawley rats.
(2015)Phosphate-dependent glutaminase (PDG) is a key enzyme in several physiological processes and hence has become a target of anti-cancer drug development because of the role of glutamine in providing energy for rapidly dividing ... -
Effects of commercially available non-nutritive sweeteners in an experimentally induced rat model of type 2 diabetes.
(2014)Non-nutritive sweeteners (NNSs) are becoming more popular as sugar substitutes for diabetic patients. Most studies have reported conflicting results and have used NNSs in their pure form; and not in the form consumed by ... -
Effects of host sex and pregnancy on Trichinella Zimbabwensis infection in Sprague-Dawley rats and Balb C mice.
(2014)Trichinellosis is a zoonotic parasitic disease caused by nematode parasites of the genus Trichinella. Trichinella species infect a wide range of hosts including humans, domestic and wild animals. The main mode of human ... -
Effects of oleanolic acid and Centella asiatica on enzymes of carbohydrate metabolism in muscle and skin of streptozotocin-induced diabetic Sprague-Dawley rats.
(2016)Diabetes prevalence increases yearly with an expected increase to 642 million people by the year 2040. Conventional treatment of diabetes involves insulin therapy and other synthetic drugs. However, drawbacks of these forms ... -
Effects of oleanolic acid on small intestine morphology and enzymes of glutamine metabolism in diabetic rats.
(2014)The small intestine (SI) is the main site for food absorption and glutamine utilization hence critical in metabolic disorders that involve energy balance such as diabetes and obesity. This study aims to assess the effects ...