Browsing Masters Degrees (Biochemistry) by Title
Now showing items 96-115 of 125
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Real-time quantitative PCR analysis of diesel-degrading genes of acinetobacter calcoaceticus isolates.
(2009)The diesel-degrading capabilities of Acinetobacter calcoaceticus isolates LT1, LT1A and V2 were established in previous studies. LT1 and LT1A were isolated from diesel-contaminated soil and V2 was from soil contaminated ... -
Recombinant cathepsin L-like cysteine proteases for species-specific diagnosis of animal African trypanosomiasis.
(2019)African trypanosomiasis is a disease caused by protozoan parasites i.e. Trypanosoma spp. in livestock and humans and affects 37 sub-Saharan countries. Animal African trypanosomiasis (AAT) is known as nagana and African ... -
Recombinant expression and bioinformatic analysis of plasmodium falciparum lactate dehydrogenase and heat shock protein 70-1.
(2017)Malaria remains a serious human health problem and the disease is particularly prevalent in developing countries. Malaria is caused by a parasite of the genus Plasmodium. Diagnosis of malaria is required before any treatment ... -
Recombinant expression and evaluation of a- and b- tubulin from Trypanosoma congolense as vaccine candidates for African trypanosomiasis.
(2010)African trypanosomiasis is caused by protozoan parasites known as trypanosomes, which are transmitted by the tsetse fly, affecting both humans and animals. Trypanosoma congolense is one of the main trypanosome species ... -
Recombinant expression and initial characterisation of two Plasmodium falciparum copper binding proteins: Cox11 and Cox19.
(2018)Emerging drug resistance hinders the efforts to control malaria and so novel antimalarial drugs are required. Copper is essential for the survival of plasmodial parasites but the proteins involved in copper homeostasis are ... -
Recombinant expression of, and characterisation of antibodies against variable surface glycoproteins : LiTat 1.3 and LiTat 1.5 of Trypanosoma brucei gambiense.
(2013)Human African Trypanosomiasis (HAT), also known as sleeping sickness is one of the many life threatening tropical diseases posing a serious risk to livelihoods in Africa. The disease is restricted to the rural poor across ... -
Recombinant expression optimisation and characterisation of peptidases for diagnosis of animal African Trypanosomosis.
(2018)Abstract available in PDF file. -
Recombinant expression, purification and characterisation of TviCATL for antibody production and diagnosis of African animal Trypanosomiasis.
(2014)For the effective control of African animal trypanosomiasis, there is a great need for the development of point of care diagnostic tests that are affordable to the end-users. Parasite cysteine proteases are involved in the ... -
Recombinant expression, purification, analysis and immunization of mice with plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase (rPyGAPDH) and lactate dehydrogenase (rPyLDH) and evaluation of protection against P. berghei challenge.
(2019)The principal focus in malaria research is the development of an effective malaria vaccine which will help to prevent death and eliminate the disease. This study investigated two plasmodial glycolytic enzymes as possible ... -
Redox properties of cathepsin B in relation to its activity in vivo.
(1999)The main site for protein degradation along the endosomal pathway is believed to be the late endosome. Lysosomes are thought to be storage organelles that, when necessary, inject proteases into the late endosome. It was ... -
Role of neutrophil matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteases-1 (TIMP-1) in the killing of microorganisms.
(2003)Microorganisms may evade killing by neutrophils (PMNs) by altering signal transduction and hence phagosome maturation. Secreted, active matrix metalloproteinases (MMPs) appear to be required for PMN killing of pseudomonas ... -
Silver nanoparticles from biological extracts and their antimicrobial activities.
(2017)The increasing incidence of multi-drug resistant organisms has led to the resurgence in application of Ag-based compounds. Accordingly, increased efforts have been made in the field of nanotechnology to develop silver ... -
The stabilisation of the cysteine protease of Carica papaya (papain) and the catalytic domain of the Cathepsin L-like cysteine protease of Trypanosoma congolense (TcoCATL)
(2019)Proteases play an intricate role in the numerous functions of a living organism. Proteases are responsible for the cleavage of proteins into smaller fragments by catalysing the hydrolysis of peptide bonds. The class of ... -
Structural studies aimed at improving the antigenicity of congopain.
(2009)African animal trypanosomosis or nagana is a tsetse fly-transmitted disease, caused by Trypanosoma congolense, T. vivax and to a lesser extent T. brucei brucei. The disease causes major losses in revenue in many ... -
Students' use of diagrams for the visualisation of biochemical processes.
(2003)Research into the usefulness of scientific diagrams as teaching and learning tools has revealed their great effectiveness in reinforcing and replacing text; summarizing, clarifying, grouping and comparing information; ... -
Studies on the possible mechanisms behind the anti-diabetic effects of Xylitol.
(2013)Background and Objectives: Sugar substitutes have gained popularity in the management of diabetes, obesity and related diseases, due to their low calorie content compared to sucrose. Recent studies have reported that ... -
Studies on the preparation and interaction of modified transferrin-DNA complexes with HeLa cells.
(1986)The correction of human genetic disorders by transfer of genetic material to cells is under intensive investigation in a number of 1aboratories. One possible way of trying to achieve the transfer of nucleic acid is ... -
A study of recombinant Plasmodium falciparum PFC0760c.
(2011)Malaria is a devastating disease caused by one of the world's most pathogenic parasites, Plasmodium. Five species of Plasmodium infect humans: P. falciparum, P. vivax, P. ovale, P. malariae and P. knowlesi. P. falciparum ... -
The study of the impact of selected mutations in FMS-like Tyrosine Kinase III (FLT3) and Nucleophosmin (NPM1) - and HIV status on patients with acute Myeloid Leukemia and their response to induction therapy.
(2012)Acute Myeloid Leukemia (AML), the most common form of acute leukemia in adults, is only curable in approximately 30% of all cases. Despite prognostic risk stratification using sub-typing and cytogenetic analysis to direct ...