Browsing Masters Degrees (Biochemistry) by Title
Now showing items 51-70 of 111
-
Hepatocyte growth factor regulates myogenesis of mouse and human skeletal myoblasts.
(2013)Satellite cells are quiescent skeletal muscle specific stem cells that are activated in response to injury to aid in muscle repair and regeneration. The interaction of hepatocyte growth factor (HGF) with these cells is ... -
Heterologous expression of invariant surface glycoproteins, ISG75 of Trypanosoma brucei brucei and T.b. gambiense, for antibody production and diagnosis of African Trypanosomiasis.
(2013)Accurate diagnosis of the presence of an infectious organism is very important for therapeutic interventions and consequently the recovery of the individual. There is a need for identifying new diagnostic antigens for the ... -
Identification of infectious bursal disease virus (IBDV) receptors through the use of recombinant capsid protein, VP2.
(2014)Infectious bursal disease virus (IBDV) is a non-enveloped Birnavirus which infects the immature antibody producing B-cells of the bursa of Fabricius in young chickens. The virus causes infectious bursal disease (IBD) which ... -
Identification of possible infectious bursal disease virus receptors.
(2000)Infectious bursal disease virus (IBDV) is a chicken pathogen that infects the bursa of Fabricius, an organ involved in the development of the immune system in chickens. Infection by the virus leads to destruction of the ... -
The impact of heavy metals on the aerobic biodegradation of 1,2-dichloroethane in soil.
(2009)1,2-Dichloroethane (1,2-DCA), a short chain chlorinated aliphatic compound, is one of the most hazardous toxic pollutant of soil and groundwater, with an annual production in excess of 5.44 × 109 kg. The major concern ... -
An in vitro assessment of functionalized gold nanoparticles in anticancer drug delivery.
(2017)Abstract available in PDF file. -
Induction of auto-antibodies to Cathepsin B.
(2001)Because tumours are comprised of "self" cells and antigens, they escape recognition by the immune system, which discriminates between "self" and "non-self". One such antigen is cathepsin B, a lysosomal cysteine proteinase, ... -
Induction of autoantibodies to cathepsin L as a step towards an anti-cancer vaccine.
(2005)Cancer is a disease that is caused by mutations in somatic cells. Metastasis is the major cause of death from cancer and often complicates treatment. Malignant tumours secrete degradative enzymes such as cathepsin L which ... -
Infectious bursal disease virus receptor identification with anti-peptide antibodies.
(2004)Infectious bursal disease virus (IBDV) has a tropism for the lymphoid tissue of poultry and infects actively dividing and differentiating B-lymphocytes in the bursa of Fabricius. This results in a high mortality rate and ... -
The influence of ionic strength on the kinetics of selected enzymes.
(2005)pH studies are used to gain insight into chemical mechanisms of enzyme catalysed reactions. However, perhaps the most important practical point that is often overlooked in pH studies is control of the ionic strength of ... -
Investigation into the major surface proteases of African trypanosomes.
(2016)The unicellular parasite of the genus Trypanosoma infects a number of mammalian species including livestock and humans. In sub-Saharan Africa three main parasitic species cause disease: Trypanosoma brucei, T. congolense ... -
An investigation into the proteolytic degradation of antimicrobial peptides by plant extracts and localisation of pleurocidin in transgenic saccharum hybrid species.
(2001)Two cationic antimicrobial peptides, ESF I-GR7, and pleurocidin, were assessed for their stability in plant intercellular fluid, the targeted locale for their expression in transgenic plants. Incubation of ESFI-GR7 and ... -
Investigation of chlorophyll and stomatal chloroplast content in diploid and tetraploid black wattle (Acacia mearnsii de Wild).
(2004)Black wattle (Acacia mearnsii) is one of South Africa's leading commercial exotic species comprising nearly seven percent of South African forestry plantations. The planting of black wattle has become increasingly popular, ... -
Investigation of the molecular adjuvant potential of Trypanosoma congolense BiP/HSP70 using congopain as model antigen.
(2011)African animal trypanosomiasis is a major threat to African agriculture causing a loss estimated to 4.5 billion US$ per annum. Trypanosoma congolense is the major causative agent in African animal trypanosomiasis and is ... -
Killing of mycobacteria by macrophage cathepsin D.
(2011)Tuberculosis (TB) is the fifth largest cause of death in South Africa, with one in ten cases being resistant to treatment due to the development of multidrug-resistance and extensively drug-resistance in the agent responsible ... -
Location and partial purification of phosphate dependent glutaminase from rat small intestine.
(2014)Phosphate dependent glutaminase (PDG) is a key enzyme in intestinal energy metabolism and hence has an impact on nutrient absorption and nutritional status of the whole animal. PDG is known to be a mitochondrial enzyme but ... -
The measurement of glomerular basement membrane components and glycated albumin as improved markers of incipient diabetic nephropathy.
(2010)Diabetes causes early structural changes to the glomerular basement membrane (GBM), which alters its function and leads to loss of protein in urine. Formation of advanced glycation endproducts (AGEs) is one mechanism ... -
Membrane permeability of HIV-1 protease inhibitors.
(2014)According to the 2012 UNAIDS global report, sub-Saharan Africa hosts 69% of the world’s total population living with HIV, South Africa being the most affected with a reported 24% incidence rate. To date, extensive research ... -
Membrane type I metalloproteinase (mt1-mmp) as a target in cancer : a study of two inhibitors.
(2013)Several diseases, including cancer, have been associated with high membrane type-1 matrix metalloproteinase (MT1-MMP) expression levels. MT1-MMP together with a non-membrane-bound, soluble MMP, MMP-2, also associated with ...