Browsing Masters Degrees (Biochemistry) by Title
Now showing items 32-51 of 109
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The effect of antiretrovirals on myoblast proliferation : migration and differentation.
(2013)Successful antiretroviral (ARV) treatment is associated with suppression of HIV viral load and the reduction of clinical disease progression. Despite marked improvements in ARV medication, side effects from long-term ... -
The effect of plant-derived oleanolic acid on selected markers of lipid metabolism and insulin signalling pathway in streptozotocin-induced diabetic rats.
(2014-06-30)Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia; this condition is caused by lack of insulin secretion (Type 1) and/or insulin resistance (Type 2). In diabetic patients; carbohydrate, ... -
The effect of Wnt isoforms on myogenesis.
(2014-09-02)Satellite cells are muscle stem cells that are responsible for the growth and repair of skeletal muscle tissue. Satellite cells typically exist in a quiescent state in their niche between the sarcolemma and basal lamina. ... -
Effects of catharanthus roseus and centella asiatica leaf extracts on enzymes of glutamine catabolism in human colon carcinoma (CACO-2) cell line and in enterocytes from male sprague-dawley rats.
(2015)Phosphate-dependent glutaminase (PDG) is a key enzyme in several physiological processes and hence has become a target of anti-cancer drug development because of the role of glutamine in providing energy for rapidly dividing ... -
Effects of commercially available non-nutritive sweeteners in an experimentally induced rat model of type 2 diabetes.
(2014)Non-nutritive sweeteners (NNSs) are becoming more popular as sugar substitutes for diabetic patients. Most studies have reported conflicting results and have used NNSs in their pure form; and not in the form consumed by ... -
Effects of host sex and pregnancy on Trichinella Zimbabwensis infection in Sprague-Dawley rats and Balb C mice.
(2015-10-16)Trichinellosis is a zoonotic parasitic disease caused by nematode parasites of the genus Trichinella. Trichinella species infect a wide range of hosts including humans, domestic and wild animals. The main mode of human ... -
Effects of oleanolic acid and Centella asiatica on enzymes of carbohydrate metabolism in muscle and skin of streptozotocin-induced diabetic Sprague-Dawley rats.
(2016)Diabetes prevalence increases yearly with an expected increase to 642 million people by the year 2040. Conventional treatment of diabetes involves insulin therapy and other synthetic drugs. However, drawbacks of these forms ... -
Effects of oleanolic acid on small intestine morphology and enzymes of glutamine metabolism in diabetic rats.
(2014)The small intestine (SI) is the main site for food absorption and glutamine utilization hence critical in metabolic disorders that involve energy balance such as diabetes and obesity. This study aims to assess the effects ... -
The effects of Sutherlandia frutescens and Fumonisin B1 on Jurkat cells.
(2011)The medicinal plant Sutherlandia frutescens (SF) is commonly consumed in South Africa, and is traditionally applied to a range of ailments. Yet its popularity stems from the use of SF as a cancer treatment. This plant ... -
The efficacy and safety of artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria in non-pregnant adults and children : a systematic review.
(2013-11-15)Effective case management of malaria is hampered by the spread of parasite resistance to nonartemisinin antimalarials. To counteract the impact of drug resistance, the World Health Organization (WHO) has endorsed ... -
Elemental composition in monocytes in response to anti-malarial drugs and hemozoin.
(2013-12-02)Every year there are approximately 300 million new cases of malaria with 2 million deaths. The majority of deaths occur in African children between the ages of 1 and 4 years and are caused by the parasite Plasmodium ... -
Endoplasmic reticulum associated degradation (ERAD) overflow pathways.
(2008)Accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes numerous human pathologies. Biochemical evidence suggests that soluble misfolded proteins are retrotranslocated out of the ER, via the endoplasmic ... -
Enzymatic and crystallisation studies of CATL-like trypanosomal cysteine peptidases.
(2011)African animal trypanosomosis or nagana is a disease in livestock caused by various species of protozoan parasites belonging to the genus Trypanosoma particularly T. congolense, T. vivax and T. b. brucei. Nagana is the ... -
Epitope mapping of a trypanosomal cysteine proteinase.
(2013-11-28)Trypanosomosis is a parasitic disease in man, domestic and wild animals and is of major economic importance in many parts of the world, particularly in Sub-Saharan Africa. Trypanosoma congolense, T vivax and T brucei ... -
Evaluation of congopain and Oligopeptidase B as anti-disease vaccines for African Trypanosomiasis.
(2008)The protozoan parasite Trypanosoma congolense is one of the aetiological agents of African animal trypanosomiasis that is transmitted by the tsetse fly. The parasite causes nagana in animals and affects livestock throughout ... -
Expression profile of Wnt isoforms during differentiation of aging C2C12 myoblast cells.
(2010)Satellite cells are known as the definitive muscle stem cells and are responsible for skeletal muscle maintenance and repair. The capacity of these satellite cells to participate in myogenesis decreases with age and as ... -
Fructose-fed streptozotocin-injected rat : an alternative model for type 2 diabetes.
(2011)The principal objective of this study was to develop an alternative non-genetic rat model for type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats (190.56 ± 23.60g) were randomly divided into six groups namely: ... -
Functional expression of Trypanosoma congolense pyroglutamyl peptidase type 1 and development of reverse genetics tools.
(2013-11-06)Trypanosoma congolense is a protozoan parasite transmitted by tsetse flies. It causes bovine trypanosomosis, the major disease for livestock in sub-Saharan Africa. Control methods include trypanocidal drugs and vector ... -
Hepatocyte growth factor regulates myogenesis of mouse and human skeletal myoblasts.
(2014-05-29)Satellite cells are quiescent skeletal muscle specific stem cells that are activated in response to injury to aid in muscle repair and regeneration. The interaction of hepatocyte growth factor (HGF) with these cells is ... -
Heterologous expression of invariant surface glycoproteins, ISG75 of Trypanosoma brucei brucei and T.b. gambiense, for antibody production and diagnosis of African Trypanosomiasis.
(2014-07-21)Accurate diagnosis of the presence of an infectious organism is very important for therapeutic interventions and consequently the recovery of the individual. There is a need for identifying new diagnostic antigens for the ...