Browsing Research papers (Caprisa) by Title
Now showing items 1-20 of 456
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The abandoned trials of pre-exposure prophylaxis for HIV : what went wrong?
(Plos., 2005)Discusses the impact of irresponsible reporting and activism against the use of the oral antiretroviral drug tenofovir as a pre-exposure prophylaxis (PREP) for HIV/AIDS. Protests against trials of PREP; Concerns of the ... -
Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline Ig gene repertoire.
(American Association of Immunologists., 2015)Abstract available in pdf. -
Acceptability of early antiretroviral therapy among South African women.
(Springer., 2018)Abstract available in pdf. -
Acceptability of HIV self-testing in sub-Saharan Africa: scoping study.
(Springer., 2018)Abstract available in pdf. -
Achieving the health Millennium Development Goals for South Africa : challenges and priorities.
(Elsevier., 2009)15 years after liberation from apartheid, South Africans are facing new challenges for which the highest calibre of leadership, vision, and commitment is needed. The effect of the unprecedented HIV/AIDS epidemic has been ... -
Adaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure.
(Elsevier., 2009)It is unresolved whether recently transmitted human immunodeficiency viruses (HIV) have genetic features that specifically favour their transmissibility. To identify potential “transmission signatures”, we compared 20 ... -
An adaptive design to bridge the gap between phase 2b/3 microbicide effectiveness trials and evidence required for licensure.
(Sage., 2012)Background. Vaginally and rectally applied microbicides are being developed to help prevent sexual acquisition of HIV. Due to the lack of surrogate outcomes, the path toward licensure typically moves directly from expanded ... -
Addressing challenges in scaling up TB and HIV treatment integration in rural primary healthcare clinics in South Africa (SUTHI): a cluster randomized controlled trial protocol.
(Implementation Science., 2015)Abstract available in pdf. -
Addressing ethical, social, and cultural issues in global health research.
(Plos., 2013)The purpose of this paper is to encourage reflection among the global health research community and the research ethics community about how a wide range of ethical, social, and cultural (ESC) influences on the conduct, ... -
Adherence challenges with drugs for pre-exposure prophylaxis to prevent HIV infection.
(Springer Verlag., 2013)Background: There are 34 million people living with human immunodeficiency virus (HIV) worldwide and each year this number increases. Until a vaccine is discovered, the prevention of new HIV infections remains an urgent ... -
Adherence in the CAPRISA 004 tenofovir gel microbicide trial.
(Springer., 2014)High adherence is key to microbicide effectiveness. Here we provide a description of adherence interventions and the adherence rates achieved in the CAPRISA 004 Tenofovir Gel Trial. Adherence support for the before-and-after ... -
Adherence in the treatment of patients with extensively drug-resistant tuberculosis and HIV in South Africa: a prospective cohort study.
(Lippincott Williams & Wilkins., 2014)Abstract available in pdf. -
Adjusting the effect of integrating antiretroviral therapy and tuberculosis treatment on mortality for non-compliance: a time-varying instrumental variables analysis.
(Wolters Kluwer., 2019)Abstract available in PDF. -
Adolescent antiretroviral management: Understanding the complexity of non-adherence.
(South African Medical Association., 2015)Abstract available in pdf. -
Adolescent girls and young women: key populations for HIV epidemic control.
(International AIDS Society., 2015)Abstract available in pdf. -
Adolescent HIV treatment issues in South Africa.
(South African Medical Association., 2015)Abstract available in pdf. -
Adolescents and HIV clinical trials: ethics, culture, and context.
(Elsevier., 2007)One quarter of HIV infections globally occur among young people 15-24 years of age and more than half of all new infections are to people younger than 25 years. Clearly, there is a need to identify and implement effective ... -
Advances in childhood immunisation in South Africa: where to now? Programme managers’ views and evidence from systematic reviews.
(BioMed Central., 2012)Background: The Expanded Programme on Immunisation (EPI) is one of the most powerful and cost-effective public health programmes to improve child survival. We assessed challenges and enablers for the programme in South ... -
Advancing STI care in low/middle-income countries : has STI syndromic management reached its use-by date?
(BMJ Group., 2017)Abstract available in pdf. -
Aetiology, clinical presentation, and outcome of meningitis in patients coinfected with human immunodeficiency virus and tuberculosis.
(Hindawi Publishing Corporation., 2011)We conducted a retrospective review of confirmed HIV-TB coinfected patients previously enrolled as part of the SAPiT study in Durban, South Africa. Patients with suspected meningitis were included in this case series. From ...