Now showing items 1-4 of 4

    • Association of TRIM22 with the Type 1 Interferon Response and Viral Control during Primary HIV-1 Infection. 

      Singh, Ravesh.; Gaiha, Gaurav.; Werner, Lise.; Mlisana, Koleka Patience.; Luban, Jeremy.; Walker, Bruce D.; Abdool Karim, Salim Safurdeen.; Ndung'u, Peter Thumbi.; Brass, Abraham.; McKim, Kevin. (American Society for Microbiology., 2010)
      Type 1 interferons (IFNs) induce the expression of the tripartite interaction motif (TRIM) family of E3 ligases, but the contribution of these antiviral factors to HIV pathogenesis is not completely understood. We hypothesized ...
    • CD8+ T cell breadth and ex vivo virus inhibition capacity distinguish between viremic controllers with and without protective HLA class I alleles. 

      Koofhethile, Catherine K.; Ndhlovu, Zaza Mtine.; Thobakgale, Christina Fanesa.; Prado, Julia G.; Ismail, Nasreen.; Mncube, Zenele.; Mkhize, Lungile.; Van der Stok, Mary Elizabeth.; Yende-Zuma, Fortunate Nonhlanhla.; Walker, Bruce D.; Goulder, Philip Jeremy Renshaw.; Ndung’u, Peter Thumbi. (American Society for Microbiology., 2016)
      Abstract available in PDF file.
    • Intersubtype differences in the effect of a rare p24 Gag mutation on HIV-1 replicative fitness. 

      Chopera, Denis Rutendo.; Cotton, Laura A.; Zawaira, Alexander.; Mann, Jaclyn Kelly.; Ngandu, Nobubelo K.; Ntale, Roman.; Carlson, Jonathan M.; Mlisana, Koleka Patience.; Woodman, Zenda.; de Assis Rosa, Debra.; Martin, Eric.; Miura, Toshiyuki.; Pereyra, Florencia.; Walker, Bruce D.; Gray, Clive M.; Martin, Darren Patrick.; Ndung'u, Peter Thumbi.; Brockman, Mark A.; Abdool Karim, Salim Safurdeen.; Brumme, Zabrina L.; Williamson, Carolyn. (American Society for Microbiology., 2012)
      Certain immune-driven mutations in HIV-1, such as those arising in p24Gag, decrease viral replicative capacity. However, the intersubtype differences in the replicative consequences of such mutations have not been explored. ...
    • Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure. 

      Mann, Jaclyn Kelly.; Chopera, Denis Rutendo.; Omarjee, Saleha.; Kuang, Xiaomei T.; Le, Anh Q.; Anmole, Gursev.; Danroth, Ryan.; Mwimanzi, Philip.; Reddy, Tarylee.; Carlson, Jonathan.; Radebe, Mopo.; Goulder, Philip Jeremy Renshaw.; Walker, Bruce D.; Abdool Karim, Salim Safurdeen.; Novitsky, Vladimir.; Williamson, Carolyn.; Brockman, Mark A.; Brumme, Zabrina L.; Ndung’u, Peter Thumbi. (Elsevier., 2014)
      Abstract available in pdf.