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Patients’ readiness to start highly active antiretroviral treatment for HIV.
(BMJ publishing group., 2005)
Assessing whether patients are ready to start antiretroviral treatment may improve HIV prevention and treatment outcomes.
Potent and Broad Neutralization of HIV-1 Subtype C by Plasma Antibodies Targeting a Quaternary Epitope Including Residues in the V2 Loop.
(American Society for Microbiology., 2010)
The targets of broadly cross-neutralizing (BCN) antibodies are of great interest in the HIV vaccine field. We
have identified a subtype C HIV-1-superinfected individual, CAP256, with high-level BCN activity, and ...
The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection.
(American Society for Microbiology., 2011)
An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals is needed to
guide vaccine design and immunization strategies. Here we used a large panel of 44 HIV-1 envelope variants
(subtypes ...
Association of HIV-Specific and Total CD8+ T Memory Phenotypes in Subtype C HIV-1 Infection with Viral Set Point.
(The American Association of Immunologists, Inc., 2009)
Understanding early immunological events during HIV-1 infection that may set the course of disease
progression is important for identifying correlates of viral control. This study explores the association
of differentiation ...
HIV-Selectest enzyme immunoassay and rapid test: ability to detect seroconversion following HIV-1 infection.
(American Society for Microbiology., 2009)
HIV-Selectest is a serodiagnostic enzyme immunoassay (EIA), containing p6 and gp41 peptides, designed to differentiate between vaccine-induced antibodies and true infections. A rapid test version of the HIV-Selectest was ...
Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external region.
(American Society for Microbiology., 2009)
We identified three cross-neutralizing plasma samples with high-titer anti-membrane proximal external
region (MPER) peptide binding antibodies from among 156 chronically human immunodeficiency virus type
1-infected ...
Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for CMV-specific CD8+ T cells.
(American Association of Immunologists., 2012)
The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it is unclear whether the maintenance of polyfunctionality is ...
Human immunodeficiency virus-specific gamma interferon enzyme-linked immunospot assay responses targeting specific regions of the proteome during primary subtype C infection are poor predictors of the course of viremia and set point.
(American Society for Microbiology., 2008)
It is unknown whether patterns of human immunodeficiency virus (HIV)-specific T-cell responses during acute infection may influence the viral set point and the course of disease. We wished to establish whether the magnitude ...
Rifampicin mono-resistance in mycobacterium tuberculosis in KwaZulu-Natal, South Africa : A significant phenomenon in a high prevalence TB-HIV region.
(PLoS One, 2013)
Setting: The dual epidemics of HIV-TB including MDR-TB are major contributors to high morbidity and mortality rates in
South Africa. Rifampicin (RIF) resistance is regarded as a proxy for MDR-TB. Currently available ...
Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 Acute Infection Study.
(Plos., 2007)
Objectives: To describe the baseline demographic data, clinical characteristics and HIV-incidence rates of a cohort at high
risk for HIV infection in South Africa as well as the challenges experienced in establishing and ...