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Effects of a reduced dose of Stavudine on the incidence and severity of peripheral neuropathy in HIV-infected adults in South Africa.
(International Medical Press., 2011)
BACKGROUND—Although recent WHO guidelines recommend withdrawing stavudine (d4T) from first-line ART therapy, it remains commonly used in resource-constrained settings. In 2006, WHO recommended decreasing the dose of d4T ...
An adaptive design to bridge the gap between phase 2b/3 microbicide effectiveness trials and evidence required for licensure.
(Sage., 2012)
Background. Vaginally and rectally applied microbicides are being developed to
help prevent sexual acquisition of HIV. Due to the lack of surrogate outcomes, the
path toward licensure typically moves directly from expanded ...
Design challenges facing clinical trials of the effectiveness of new HIV prevention technologies.
(Lippincott Williams & Wilkins., 2012)
Recent successes of antiretroviral pre-exposure prophylaxis (PrEP) in preventing HIV infection
have raised questions whether further placebo controlled trials of new HIV-prevention
technologies are ethically justifiable. ...
Declining adherence is a more likely explanation than frailty of the apparent decline in efficacy in the CAPRISA 004 trial: response to O’Hagan et al.
(Lippincott Williams & Wilkins., 2012)
No abstract available.
Improved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatment in the SAPiT trial.
(International Journal of Tuberculosis and Lung Disease., 2014)
BACKGROUND: The therapeutic effects of antiretroviral treatment (ART) in patients with multidrug-resistant tuberculosis (MDR-TB) and human immunodeficiency virus (HIV) infection have not been established.
Objective : ...
Cost-effectiveness of initiating antiretroviral therapy at different points in TB treatment in HIV-TB co-infected ambulatory patients in South Africa.
(Wolters Kluwer., 2015)
Abstract available in pdf.
Determinants of optimal adherence over time to antiretroviral therapy amongst HIV positive adults in South Africa : a longitudinal study.
(Springer Verlag., 2011)
Highly active antiretroviral therapy (HAART) requires strict adherence to achieve optimal clinical
and survival benefits. A study was done to explore the factors affecting HAART adherence among
HIV positive adults ...
Factors affecting first-month adherence to antiretroviral therapy among HIV-positive adults in South Africa.
(Taylor & Francis co-published with NISC., 2010)
This study explores the influence of baseline factors on first-month adherence to highly active antiretroviral therapy (HAART) among adults. The study design involved a review of routinely collected patient information in ...
Innate antibacterial activity in female genital tract secretions is associated with increased risk of HIV acquisition.
(Mary Ann Liebert., 2015)
Abstract available in pdf.
Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa.
(BioMed Central., 2007)
Background. Few studies address the use of paediatric highly active antiretroviral therapy (HAART) in Africa.
Methods. We performed a retrospective cohort study to investigate preliminary outcomes of all children eligible ...