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Now showing items 1-10 of 36
Effects of a reduced dose of Stavudine on the incidence and severity of peripheral neuropathy in HIV-infected adults in South Africa.
(International Medical Press., 2011)
BACKGROUND—Although recent WHO guidelines recommend withdrawing stavudine (d4T) from first-line ART therapy, it remains commonly used in resource-constrained settings. In 2006, WHO recommended decreasing the dose of d4T ...
An adaptive design to bridge the gap between phase 2b/3 microbicide effectiveness trials and evidence required for licensure.
(Sage., 2012)
Background. Vaginally and rectally applied microbicides are being developed to
help prevent sexual acquisition of HIV. Due to the lack of surrogate outcomes, the
path toward licensure typically moves directly from expanded ...
Design challenges facing clinical trials of the effectiveness of new HIV prevention technologies.
(Lippincott Williams & Wilkins., 2012)
Recent successes of antiretroviral pre-exposure prophylaxis (PrEP) in preventing HIV infection
have raised questions whether further placebo controlled trials of new HIV-prevention
technologies are ethically justifiable. ...
Declining adherence is a more likely explanation than frailty of the apparent decline in efficacy in the CAPRISA 004 trial: response to O’Hagan et al.
(Lippincott Williams & Wilkins., 2012)
No abstract available.
Key issues in the clinical development and implementation of TB vaccines in South Africa.
(Elsevier., 2012)
Significant progress has been made in advancing the development pipeline for a new and more effective
TB vaccine with some candidate vaccines now in late stage clinical evaluation. However, progress has
been hampered ...
HIV prevention trial design in an era of effective pre-exposure prophylaxis.
(American Association for the Advancement of Science., 2017)
Abstract available in pdf.
Improved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatment in the SAPiT trial.
(International Journal of Tuberculosis and Lung Disease., 2014)
BACKGROUND: The therapeutic effects of antiretroviral treatment (ART) in patients with multidrug-resistant tuberculosis (MDR-TB) and human immunodeficiency virus (HIV) infection have not been established.
Objective : ...
Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 Acute Infection Study.
(Plos., 2007)
Objectives: To describe the baseline demographic data, clinical characteristics and HIV-incidence rates of a cohort at high
risk for HIV infection in South Africa as well as the challenges experienced in establishing and ...
Anaemia in acute HIV-1 Subtype C infection.
(Plos., 2007)
Background: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during
AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin ...
HIV prevention in high-risk women in South Africa: condom use and the need for change.
(Plos., 2011)
Introduction: Young women are at disproportionate risk of HIV infection in South Africa. Understanding risk behaviors and factors associated with ability to negotiate safe sex and condom use is likely to be key in curbing ...