Now showing items 1-10 of 28
The role of angiotensin ll and oxidative stress in the spontaneously hypertensive rat.
Oxidative stress resulting from an imbalance between free radicals and antioxidants is considered to be an important etiological factor in the development and maintenance of hypertension. Angiotensin II (Ang II) has been ...
The effect of vitamin B-6 deficiency on copper, zinc and iron balance in the rat.
In order to address the contradictory reports on the rat trace element status during a vitamin 8-6 deficiency, Zn, Cu and Fe balance was assessed over 8 weeks in 3 groups of young male rats. Group 1 was the control group ...
Evaluating a new drug to combat alzheimer's disease.
Alzheimer’s disease (AD), a progressive neurodegenerative disorder that affects mostly the limbic system and the neocortical areas of the brain, is the most prevalent form of dementia affecting the elderly population. ...
Immunohistochemical and ultrastructural evaluation of the pathology and aetiopathogenesis of keloid formation.
Introduction Keloids are formed by the excessive production of scar tissue, which extends beyond the margins of the original injury, often resulting in lesions of grotesque dimensions. Keloids present a major dilemma ...
The optimisation of a preeclampsia-like L-NAME rat model : a focus on utero-placental dysfunction.
Preeclampsia is a multi-system pregnancy syndrome characterized by the sudden onset of hypertension, escalated proteinuria and in some cases oedema usually after 20 weeks of gestation. Preeclampsia is further categorized ...
A quantification of heat load as assessed by indicators of tissue damage in rats.
Heatstroke is an illness that occurs when body temperature is grossly elevated, causing widespread tissue damage. The extent of tissue damage depends on the level of body temperature elevation and the duration. Despite ...
Tat protein induced neurocognitive dysfunction.
Human immunodeficiency virus type 1 (HIV-1) is a major health threat in South Africa. Studies have shown that HIV affects the central nervous system (CNS), and can initiate a progressive neurodegenerative process culminating ...
Effects of maslimic acid and related triterpene derivatives on kidney function of male Sprague-Dawley rats.
Reports indicate that hyperglycaemia leads to development of kidney complications which result in sodium retention, decrease in glomerular filtration rate (GFR) and high blood pressure. Various biochemical processes such ...
The effects of oxidovanadium complexes on glucose metabolism in liver and skeletal muscle cell lines.
Abstract available in PDF file.
Evaluation of the efficacy of Syzygium aromaticum-derived Oleanolic acid on malaria parasites in Plasmodium berghei-infected male Sprague-Dawley rats and effects on blood glucose and renal electrolyte handling.
Introduction Malaria continues to be one of the major causes of morbidity and mortality worldwide even though the disease is treatable. This is as a result of malaria parasites developing resistance to current antimalarial ...