Browsing Masters Degrees (Medical Biochemistry) by Issue Date
Now showing items 1-20 of 26
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Analysis of a multidrug resistant acinetobacter SPP. outbreak in the intensive care unit of King Edward VIII Hospital.
(2000)The study arose out of a need to investigate and control a nosocomial outbreak caused by multidrug resistant Acinetobacter spp in the fifteen-bed intensive care unit of King Edward VIII Hospital. Following the discovery ... -
An investigation into the effects of Sutherlandia Frutescens, L-Canavanine and aflatoxin B1 in the HepG2 human hepatocarcinoma cell line.
(2008)Aflatoxin B1 (AFB1), a potent hepatotoxic and hepatocarcinogenic mycotoxin synthesised by toxigenic fungi (Aspergillus flavus and Aspergillus parasiticus), is a common contaminant of many cereal commodities consequently ... -
An in vivo study to determine the effects of Ochratoxin A and Sutherlandia frutescens in male Wistar rats.
(2009)Ochratoxin A (OTA), a nephrotoxic mycotoxin, is a contaminant of several agricultural food products consumed by animals and humans. Apart from renal toxicity, in particular renal tumours, OTA may also result in teratogenicity, ... -
The effects of Sutherlandia frutescens in cultured renal proximal and distal tubule epithelial cells.
(2009)Sutherlandia frutescens (SF), an indigenous medicinal plant to South Africa (SA), is traditionally used to treat a diverse range of illnesses including cancer and viral infections. The biologically active compounds of SF ... -
Biotyping Saccharomyces cerevisiae strains using matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS)
(2011)In clinical diagnosis and fermentation industries there is a need for a method that allows for the differentiation of yeast to the strain level (biotyping). The ideal biotyping method should be accurate, simple, rapid ... -
Silver nanoparticles of Albizia adianthifolia : the induction of apoptosis in a human lung carcinoma cell line.
(2012)Silver nanoparticles (AgNP), the most popular nano-compounds, possess unique chemical, physical and biological properties. Albizia adianthifolia (AA) – rich in saponins – is a plant of the Fabaceae family, found abundantly ... -
The effects of fumonisin B¹ in preeclampsia.
(2012)Preeclampsia is the leading cause of foetal and maternal mortality and morbidity in developing countries. In South Africa, maize is a dietary staple for most black African populations and is susceptible to contamination ... -
The effects of Tulbaghia violacea leaf, bulb and stalk extracts on Jurkat cells.
(2012)Studies have shown that the traditional healers have used Tulbaghia violacea (TV) (also known as ‘wild garlic’) for the treatment of a number of ailments including fever, tuberculosis, stomach problems, and oesophageal ... -
Characterisation of Fumonisin B1 toxicity in a cancerous liver cell line- induction of tissue transglutaminase and the endoplasmic reticulum stress pathway.
(2013)Fumonisin B1 (FB1) is a mycotoxin which is well characterised as a contaminant of maize and maize-based products worldwide, especially in South Africa. Its toxic effects have been associated with hepatotoxicity, nephrotoxicity ... -
The effects of Tulbaghia violacea (wild garlic) leaf and bulb extracts on an oesophageal cancer cell line (SNO)
(2013-10-23)Ethnopharmacological relevance: Indigenous plants such as Tulbaghia violacea(TV) and Allium sativum (garlic) are traditionally used as natural remedies to treat a variety of ailments, including cancer. This study investigated ... -
The role of the uncoupling protein2 -866G/A polymorphism in oxidative stress markers associated with air pollution exposure during pregnancy.
(2013-10-23)Consistently high levels of air pollutants such as sulphur dioxide, particle matter and nitric oxides have been observed in the Durban South (DS) industrial basin. The adverse health outcomes associated with ambient air ... -
Isolation and characterisation of extended spectrum B-lactamases in South African Klebsiella pneumonia isolates.
(2013-12-04)The use of antibiotics and antimicrobial drugs has played a large role in the elimination of many infectious diseases, however the wide spread use of such drugs has given rise to the phenomenon of antimicrobial resistance ... -
Trigonella foenum-graecum seed and 4-hydroxyisoleucine mediates glucose uptake via proximal insulin signaling activation and related downstream gene expression in liver cells.
(2014)Fenugreek (Trigonella foenum-graecum) is one of the oldest medicinal plants used worldwide to treat a variety of ailments, including hyperglycaemia. The seed and active compound – 4-hydroxyisoleucine (4-OH-lle) is thought ... -
The phytoalexin, resveratrol ameliorates ochratoxin A genotoxicity in human embryonic kidney (HEK293) cells.
(2014)Background: Ochratoxin A (OTA) is a mycotoxin produced by fungal species of Aspergillus and Penicillium. OTA is nephrotoxic and carcinogenic in several animal models; it frequently contaminates human and animal food products. ... -
Antiproliferative effect of a novel synthesized carbazole compound on A549 lung cancer cell line.
(2014)Increased death rates due to lung cancer have necessitated the search for potential novel anticancer compounds such as carbazole derivatives. Carbazoles are aromatic heterocyclic compounds with anticancer, antibacterial ... -
Involvement of MAPK and Akt in the immunotoxicity of fusaric acid on healthy peripheral blood mononuclear cells (PBMC) and acute monocytic leukemic (Thp-1) cells.
(2015)Fusaric acid is a divalent chelator with moderate toxicity in plant and animals. However, studies lack on its effect on human models and the immune system. This study investigated the immunotoxicity of FA on PBMCs and ... -
Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells.
(2015)Abstract available in PDF file. -
An investigation into the clinical outcomes of women with peripartum cardiomyopathy at Klerksdorp/Tshepong Hospital Complex.
(2015)Introduction: Peripartum Cardiomyopathy (PPCM) is defined on the basis of 4 criteria: The development of cardiac failure in the last month of pregnancy and up to 5 months after delivery; Absence of an identifiable ... -
HMG-CoA reductase inhibitor, atorvastatin induces apoptasis in human lung adenocarcinoma cell (A549).
(2015)Abstract available in PDF file. -
An investigation into marine bacterial species found in shark mouths in the Indian Ocean and their implications for human health.
(2015-05-12)There is an ever increasing amount of pollution and waste being released into the environment. This is due to the increase in population, urbanisation and people migrating into cities. Approximately 2.4 billion people ...