Browsing Medical Biochemistry by Issue Date
Now showing items 1-20 of 53
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Molecular and biochemical aspects of the kallikrein-kinin system in oesophageal carcinoma.
(1999)Abstract available in PDF file. -
Analysis of a multidrug resistant acinetobacter SPP. outbreak in the intensive care unit of King Edward VIII Hospital.
(2000)The study arose out of a need to investigate and control a nosocomial outbreak caused by multidrug resistant Acinetobacter spp in the fifteen-bed intensive care unit of King Edward VIII Hospital. Following the discovery ... -
An investigation into the effects of Sutherlandia Frutescens, L-Canavanine and aflatoxin B1 in the HepG2 human hepatocarcinoma cell line.
(2008)Aflatoxin B1 (AFB1), a potent hepatotoxic and hepatocarcinogenic mycotoxin synthesised by toxigenic fungi (Aspergillus flavus and Aspergillus parasiticus), is a common contaminant of many cereal commodities consequently ... -
The effects of Sutherlandia frutescens in cultured renal proximal and distal tubule epithelial cells.
(2009)Sutherlandia frutescens (SF), an indigenous medicinal plant to South Africa (SA), is traditionally used to treat a diverse range of illnesses including cancer and viral infections. The biologically active compounds of SF ... -
Biochemical, apoptotic and cellular stress studies in rheumatoid arthritis.
(2009)Abstract available in PDF file. -
An in vivo study to determine the effects of Ochratoxin A and Sutherlandia frutescens in male Wistar rats.
(2009)Ochratoxin A (OTA), a nephrotoxic mycotoxin, is a contaminant of several agricultural food products consumed by animals and humans. Apart from renal toxicity, in particular renal tumours, OTA may also result in teratogenicity, ... -
Biotyping Saccharomyces cerevisiae strains using matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS)
(2011)In clinical diagnosis and fermentation industries there is a need for a method that allows for the differentiation of yeast to the strain level (biotyping). The ideal biotyping method should be accurate, simple, rapid ... -
The effects of Tulbaghia violacea leaf, bulb and stalk extracts on Jurkat cells.
(2012)Studies have shown that the traditional healers have used Tulbaghia violacea (TV) (also known as ‘wild garlic’) for the treatment of a number of ailments including fever, tuberculosis, stomach problems, and oesophageal ... -
An assessment of gene polymorphisms in young South African Indians with coronary artery disease and the effect of atorvastan in vitro.
(2012)The global burden of heart disease increases every year. It has been estimated that by the year 2020, coronary artery disease (CAD) will be the number one cause of death worldwide. Indian populations throughout the world ... -
The effects of fumonisin B¹ in preeclampsia.
(2012)Preeclampsia is the leading cause of foetal and maternal mortality and morbidity in developing countries. In South Africa, maize is a dietary staple for most black African populations and is susceptible to contamination ... -
Silver nanoparticles of Albizia adianthifolia : the induction of apoptosis in a human lung carcinoma cell line.
(2012)Silver nanoparticles (AgNP), the most popular nano-compounds, possess unique chemical, physical and biological properties. Albizia adianthifolia (AA) – rich in saponins – is a plant of the Fabaceae family, found abundantly ... -
The role of the uncoupling protein2 -866G/A polymorphism in oxidative stress markers associated with air pollution exposure during pregnancy.
(2012)Consistently high levels of air pollutants such as sulphur dioxide, particle matter and nitric oxides have been observed in the Durban South (DS) industrial basin. The adverse health outcomes associated with ambient air ... -
Characterisation of Fumonisin B1 toxicity in a cancerous liver cell line- induction of tissue transglutaminase and the endoplasmic reticulum stress pathway.
(2013)Fumonisin B1 (FB1) is a mycotoxin which is well characterised as a contaminant of maize and maize-based products worldwide, especially in South Africa. Its toxic effects have been associated with hepatotoxicity, nephrotoxicity ... -
The effects of Tulbaghia violacea (wild garlic) leaf and bulb extracts on an oesophageal cancer cell line (SNO)
(2012)Ethnopharmacological relevance: Indigenous plants such as Tulbaghia violacea(TV) and Allium sativum (garlic) are traditionally used as natural remedies to treat a variety of ailments, including cancer. This study investigated ... -
Antibiotic resistance in the food chain : a case study of Campylobacter spp. in poultry.
(2013)The sub-therapeutic use of antibiotics for growth promotion in food animal production, has engendered substantial debate on the dissemination of antibiotic resistance via the food chain, specifically, the probability of ... -
Isolation and characterisation of extended spectrum B-lactamases in South African Klebsiella pneumonia isolates.
(2012)The use of antibiotics and antimicrobial drugs has played a large role in the elimination of many infectious diseases, however the wide spread use of such drugs has given rise to the phenomenon of antimicrobial resistance ... -
Antiproliferative effect of a novel synthesized carbazole compound on A549 lung cancer cell line.
(2014)Increased death rates due to lung cancer have necessitated the search for potential novel anticancer compounds such as carbazole derivatives. Carbazoles are aromatic heterocyclic compounds with anticancer, antibacterial ... -
An investigation into the biochemical, molecular and epigenetic effects of fumonisin B1 in liver (HEPG2) cells.
(2014)Fumonisins are carcinogenic mycotoxins that occur world wide in maize and maizebased products intended for human consumption. Consumption of fumonisincontaminated maize as a staple diet has been associated with oesophageal ... -
Trigonella foenum-graecum seed and 4-hydroxyisoleucine mediates glucose uptake via proximal insulin signaling activation and related downstream gene expression in liver cells.
(2014)Fenugreek (Trigonella foenum-graecum) is one of the oldest medicinal plants used worldwide to treat a variety of ailments, including hyperglycaemia. The seed and active compound – 4-hydroxyisoleucine (4-OH-lle) is thought ... -
The phytoalexin, resveratrol ameliorates ochratoxin A genotoxicity in human embryonic kidney (HEK293) cells.
(2014)Background: Ochratoxin A (OTA) is a mycotoxin produced by fungal species of Aspergillus and Penicillium. OTA is nephrotoxic and carcinogenic in several animal models; it frequently contaminates human and animal food products. ...