Browsing Medical Biochemistry by Title
Now showing items 13-32 of 47
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The effects of fumonisin B¹ in preeclampsia.
(2012)Preeclampsia is the leading cause of foetal and maternal mortality and morbidity in developing countries. In South Africa, maize is a dietary staple for most black African populations and is susceptible to contamination ... -
The effects of Sutherlandia frutescens in cultured renal proximal and distal tubule epithelial cells.
(2009)Sutherlandia frutescens (SF), an indigenous medicinal plant to South Africa (SA), is traditionally used to treat a diverse range of illnesses including cancer and viral infections. The biologically active compounds of SF ... -
The effects of Tulbaghia violacea (wild garlic) leaf and bulb extracts on an oesophageal cancer cell line (SNO)
(2012)Ethnopharmacological relevance: Indigenous plants such as Tulbaghia violacea(TV) and Allium sativum (garlic) are traditionally used as natural remedies to treat a variety of ailments, including cancer. This study investigated ... -
The effects of Tulbaghia violacea leaf, bulb and stalk extracts on Jurkat cells.
(2012)Studies have shown that the traditional healers have used Tulbaghia violacea (TV) (also known as ‘wild garlic’) for the treatment of a number of ailments including fever, tuberculosis, stomach problems, and oesophageal ... -
Fumonisin B1-induced oxidative stress in human liver (HepG2) cells – an alternate mechanism of carcinogenesis.
(2017)Abstract available in pdf. -
Fumonisin B2 induces mitochondrial stress and mitophagy in Hek293 cells.
(2019)Food insecurity poses a significant socio-economic problem in third world economies, particularly in countries that rely heavily on maize and maize products. Ubiquitous soil fungi parasitize agricultural commodities and ... -
Fusaric acid dampens the Nrf2-mediated stress response in human embryonic kidney cells.
(2016)Abstract available in PDF file. -
Fusaric acid induces DNA damage and post-translational modification Of p53 in hepatocellular carcinoma (HepG2) cells.
(2016)Abstract available in PDF file. -
Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells.
(2015)Abstract available in PDF file. -
Fusaric acid induces oxidative stress and apoptosis in human oesophageal cancer cells.
(2016)Abstract available in PDF file. -
Fusaric acid-induced epigenetic modifications in vitro and in vivo: alternative mechanisms of hepatotoxicity.
(2019)The Fusarium-produced mycotoxin, Fusaric acid (FA), is a frequent contaminant of agricultural foods that exhibits toxicity in plants and animals with little information on its molecular and epigenetic mechanisms. Epigenetic ... -
HMG-CoA reductase inhibitor, atorvastatin induces apoptasis in human lung adenocarcinoma cell (A549).
(2015)Abstract available in PDF file. -
Hyperglycaemic-induced regulation of SIRT3 and downstream antioxidant profile.
(2015)Hyperglycaemia increases reactive oxygen species (ROS) production and mitochondrial dysfunction which are involved in metabolic disorders. Sirtuin 3 (SIRT3) is a primary mitochondrial deacetylase that regulates mitochondrial ... -
An in vitro and in vivo evaluation of the immuno and neurotoxicological effects of fusaric acid on altered protein kinase signalling cascades.
(2019)Mycotoxins are naturally occurring toxins produced by moulds which contaminate numerous crops and foodstuffs including cereals, nuts and fruits. When consumed, mycotoxins pose a serious threat to both human and animal ... -
An in vivo study to determine the effects of Ochratoxin A and Sutherlandia frutescens in male Wistar rats.
(2009)Ochratoxin A (OTA), a nephrotoxic mycotoxin, is a contaminant of several agricultural food products consumed by animals and humans. Apart from renal toxicity, in particular renal tumours, OTA may also result in teratogenicity, ... -
An investigation into marine bacterial species found in shark mouths in the Indian Ocean and their implications for human health.
(2015)There is an ever increasing amount of pollution and waste being released into the environment. This is due to the increase in population, urbanisation and people migrating into cities. Approximately 2.4 billion people ... -
An investigation into the biochemical, molecular and epigenetic effects of fumonisin B1 in liver (HEPG2) cells.
(2014)Fumonisins are carcinogenic mycotoxins that occur world wide in maize and maizebased products intended for human consumption. Consumption of fumonisincontaminated maize as a staple diet has been associated with oesophageal ... -
An investigation into the clinical outcomes of women with peripartum cardiomyopathy at Klerksdorp/Tshepong Hospital Complex.
(2015)Introduction: Peripartum Cardiomyopathy (PPCM) is defined on the basis of 4 criteria: The development of cardiac failure in the last month of pregnancy and up to 5 months after delivery; Absence of an identifiable ... -
An investigation into the clinical, biochemical, immunological and epigenetic factors in black South Africa women with preeclampsia and HIV.
(2015)Introduction: Preeclampsia (PE) and HIV/AIDS contribute significantly to adverse maternal and perinatal outcomes globally. The treatment of PE remains empiric, however in HIV infection, highly active antiretroviral therapy ...