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The role of natural killer cells in preventing HIV-1 acquisition and controlling disease progression.
(2013)
In sub-Saharan Africa, women carry a disproportionate burden of the Human
Immunodeficiency Virus Type 1 (HIV-1) pandemic. The high risk of HIV
acquisition in these women and the variability in their disease progression ...
Nucleoside reverse transcriptase inhibitors-associated mutations in the RNase H region of HIV-1 isolates in South African adults and children failing highly active antiretroviral therapy.
(2012)
Background: The South African national treatment program includes NRTIs in both first and
second line highly active antiretroviral therapy regimens. Recently, mutations in the RNase H
domain have been associated with ...
Impact of p2/NC cleavage site polymorphisms on HIV-1 subtype C viral fitness.
(2012)
Subtype C accounts for the majority of HIV infections and in South Africa, is the dominant subtype. The Gag cleavage sites of subtype C viruses show a high degree of natural variation compared to subtype B and group M ...
The role of the protease cleavage sites in viral fitness and drug resistance in HIV-1 subtype C.
(2010)
There is an increasing number of patients failing second line highly active antiretroviral therapy
(AZT, DDI and LPV/r) in South Africa, where HIV-1 subtype C predominates. Mutations at gag
cleavage sites (CS) have ...
Allele-specific polymerase chain reaction (ASPCR) to detect resistance mutations in minor variants of HIV-1 subtype C in patients failing highly active antiretroviral therapy (HAART).
(2014)
The World Health Organization (WHO) has recommended Tenofovir disoproxil fumarate (TDF) as one of the preferred first-line antiretrovirals (ARVs). TDF and Abacavir (ABC) were introduced into the South African National ...
Minority HIV-1 drug resistance mutations in patients failing highly active antiretroviral therapy (HAART).
(2014)
Abstract not available.
Acquired and transmitted drug resistance in HIV-1 subtype C : implications of novel mutations on replication capacity, cleavage and drug susceptibility.
(2015)
Introduction
Large scale roll-out of combination antiretroviral therapy (cART) has been successful in improving the quality of life of HIV-1 infected individuals in South Africa (SA). However the development and transmission ...
Characterizing protease inhibitor failure in HIV-1 subtype C, using ultra deep pyro-sequencing and homology modelling.
(2015)
The extensive roll-out of combination antiretroviral therapy (cART) has significantly
improved the life expectancy for HIV-1 infected individuals in South Africa. Despite
the inclusion of potent Protease Inhibitors (PIs) ...
The influence of HIV-1 genomic target region selection and sequence length on the accuracy of inferred phylogenies and clustering outcomes.
(2017)
To improve the methodology of HIV-1 cluster analysis, we addressed how analysis of HIV-1
clustering is associated with parameters that can affect the outcome of viral clustering. The
extent of HIV clustering, tree ...