Browsing Masters Degrees (Pharmaceutical Sciences) by Issue Date
Now showing items 1-20 of 134
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An investigation into the effects and possible mechanisms of action of cimetidine and ranitidine on the sexual behaviour of male rats.
(1985)The development of a new class of antihistamines, the H2-receptor antagonists, introduced a new era in the treatment of peptic ulcer diseases. Cimetidine, the first clinically effective H2-blocker, was introduced ... -
The effect of alcohol, isoniazid, rifampicin, paracetamol and hexane on hepatic gluconeogenesis and bromosulphthalein clearance.
(1988)The first workers to use the isolated perfused rat liver for the study of gluconeogenesis were Corey and Britton (1941). Subsequently, other investigators found the modified method of Miller et al (1951) to be more ... -
The influence of the application of pharmacokinetics on the effects of theophylline utilisation upon members of the Indian population.
(1989)Theophylline is a dimethylated xanthine similar in structure to caffeine which is commonly found in tea, coffee and cola beverages (Hendeles and Weinberger, 1983; Rall, 1985). Clinically, its most important pharmacological ... -
The pharmacokinetics of phenobarbitone in fasting and non-fasting dogs.
(1990)Practicing clinical veterinarians in large companion animal practices are often faced with the phenomena of epileptic seizures which occur commonly in dogs. The high incidence of non-responsive cases is often frustrating, ... -
Pharmaceutical availability on newly formulated oral sustained release pellets containing the antihistamine, chlorpheniramine maleate.
(1991)The main objective of the present study was to determine the feasibility of obtaining aqueous polymer-coated pellet formulations using EudragitR NE 30 D dispersion and chlorpheniramine maleate as the model drug. Many factors ... -
Formulation, evaluation and characterization of an oral modified realease naproxen sodium preparation.
(1997)The motivation for the present study is systematically presented and the aims and objectives of the study are clearly defined. A comprehensive review on modified release drug delivery has been presented to provide ... -
Formulation and evaluation of modified release eudragit® matrices containing diclofenac sodium.
(1998)The aim of the present study was to formulate oral modified release matrices of diclofenac sodium, using the Eudragit® polymers. In addition to the formulation processes, numerous variables had to be investigated, which ... -
Drug-related problems among geriatric outpatients at a public sector hospital : an intervention study.
(2000)Introduction: Although drug-related problems (DRPs) are known to be prevalent in elderly patients, there are not many studies that have been performed in geriatric outpatients at public health facilities in South Africa. ... -
Antimicrobial and chemical analyses of selected bulbine species.
(2000)The use of plant materials for the treatment of various diseases is very common in African countries. As traditional medicine used by the rural people does not always have a proper scientific basis, research programmes ... -
Studies on molluscicidal properties of some South African medicinal plants used in the control of schistosomiasis in KwaZulu-Natal.
(2002)Schistosomiasis is an important public health issue for rural communities located near,or around slow moving water bodies in the tropical and subtropical areas. Successful control of the disease involves multifaceted ... -
A retrospective analysis of subjects who have approved gastro-oesophageal reflux disease (GORD) from a private medical aid fund.
(2006)Abstract not available. -
Effects of acetylcholine on isolated urinary bladders of normal and streptozotocin-treated diabetic rats.
(2006)This study was prompted by the inconsistent reports and apparent controversies that exist in the biomedical literature on the responses of diabetic bladder strips to cholinergic nerve stimulation or exogenous administration ... -
Multipolymeric monolayered mucoadhesive films for drug therapy.
(2007)The use of the oral cavity membranes as sites of drug administration has been a topic of increasing interest for the past decade. The buccal route, in particular, offers several advantages over the per oral route and may ... -
Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats.
(2008)Background: Evidence from our laboratories indicates that triterpene constituents of Syzygium cordatum (Hochst.) [Myrtaceae] crude leaf extracts can be used to treat diabetes mellitus. For the plant derived triterpenes to ... -
Pharmacological effects of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) Corm ("African Potato") aqueous extract on some mammalian extra-vascular smooth muscles in vitro.
(2009)Extracts of Hypoxis hemerocallidea corm (African potato) are commonly used by some traditional health practitioners in KwaZulu-Natal Province of South Africa for an array of human ailments. This study was, therefore, ... -
Measure of pharmacists role in the management and adherence of HIV infected patients in a public sector hospital of KwaZulu-Natal.
(2011)Background:- The HIV and AIDS epidemic is a major catastrophe that affects millions of people worldwide. Antiretroviral medication combinations have revolutionised HIV treatment since 1996, transforming the virus from ... -
The toxicological properties of Scilla nervosa (Burch.) Jessop (Hyacinthaceae) in cultured HepG2 liver cells.
(2011)Background and Aims of Study. Scilla nervosa is a member of the Hyacinthaceae plant family that has been naturalised in the grasslands of Southern Africa. The bulbs are traditionally used to treat a variety of ailments. ... -
Formulation and evaluation of mucoadhesive polymeric films for buccal delivery of didanosine.
(2013)The development of new chemical entities, novel drug delivery systems and alternative routes to deliver antiretrovirals (ARVs) are being explored to overcome the numerous limitations associated with HIV & AIDS drug therapy. ...