Browsing School of Health Sciences by Title
Now showing items 189-208 of 294
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Mapping immunodominant patterns and HLA class II restriction characteristics of HIV-specific CD4+ T cell responses in acute and chronic HIV-1 subtype C infection.
(2014)Increasing evidence suggests that virus-specific CD4+ T cells contribute to immune-mediated control of HIV-1 infection. However, precise details of CD4+ T cell contribution to immune protection against HIV have not been ... -
Mass spectrometric imaging for Tuberculosis drug development.
(2017)For many years, Tuberculosis (TB) has plagued the human race claiming millions, if not billions, of lives. With the advent of short-course chemotherapy TB has become a manageable disease, however in recent times Mycobacterium ... -
Matching a chelator (DOTA) with ions for radio-pharmaceutical applications using DFT study.
(2016)Organometallic chelators can be potentially used for radiometal-based pharmaceuticals. The bifunctional chelator, which is covalently bound to a lead compound, forms a stable chelator―ion complex to deliver an isotope, as ... -
Matrix assisted laser desorption/ionisation time of flight mass spectrometry (MALDI-TOF MS) proteomic profiling of mycobacteria.
Mycobacterium tuberculosis still remains a major cause of tuberculosis(TB) and death. In addition, nontuberculous mycobacteria (NTM) play a significant role in the aetiology of tuberculosis-like syndromes. A diagnosis ... -
Measure of adherence to antiretroviral treatment amongst HIV positive patients attending antiretroviral clinics in selected rural, deep-rural and semi-urban areas of Ugu District in KwaZulu-Natal.
(2017)Background The roll-out of antiretroviral (ARV) treatment in public health facilities was initiated in 2004 in the KwaZulu-Natal province. The roll-out made ARV treatment available and accessible to the vast majority of ... -
Measure of pharmacists role in the management and adherence of HIV infected patients in a public sector hospital of KwaZulu-Natal.
(2011)Background:- The HIV and AIDS epidemic is a major catastrophe that affects millions of people worldwide. Antiretroviral medication combinations have revolutionised HIV treatment since 1996, transforming the virus from ... -
Measurement of vaginal microbicide adherence using visual inspection as compared to ultra violet light assessment of returned empty gel applicators.
(2015)Introduction Finding a safe, effective and acceptable HIV prevention method is key to preventing new infections in women. Vaginal microbicide trials aim to do so, but adherence to study product remains a challenge in ... -
Meeting South Africa's pharmacovigilance challenges in the face of rapidly increasing public health treatment programmes.
(2016)Among South Africa‘s (SA‘s) many public health challenges, having the largest treatment programmes globally is a significant challenge. The latter requires a robust pharmacovigilance (PV) programme. The purpose of this ... -
Metformin does not prevent glucose intolerance but improves renal function and reduces oxidative stress in type 1 diabetes.
(2016)Type 1 diabetes (T1D) is a chronic condition caused by the complete destruction of insulin producing pancreatic β-cells. Increased oxidative stress and impaired antioxidant capacity are associated with the development ... -
The methyltransferase and helicase enzymes as therapeutic targets of Zika virus : a bio- computational analysis of interactions with potential inhibitors.
(2019)The rampant Zika virus has received worldwide attention after becoming a global crisis following the Brazilian epidemic in 2015. From an obscure and neglected pathogen, Zika virus is now a notorious virus associated with ... -
Molecular analysis of HIV-1 resistance: biosynthesis, kinetic, and thermodynamic study of resistant HIV-PROTEASE (C-SA) mutants.
(2018)Abstract available in pdf. -
Molecular dynamics study of HIV-1 protease inhibitors and their effects on the flap dynamics of the HIV-1 subtype-C (C-SA).
(2018)The aspartyl protease human immunodeficiency virus type 1 (HIV-1) is a 99-amino acid-long homodimer responsible for processing the Gag and Gag-Pol polyproteins into functional constituent proteins necessary for development ... -
Molecular epidemiology of livestock-associated Methicillin resistant Staphylococcus aureus (LA-MRSA) and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in pigs and exposed workers in Cameroon and South Africa.
(2017)Livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA) and extendedspectrum β-Lactamase (ESBL)-producing Enterobacteriaceae (ESBL-PE) are amongst the main resistant bacteria of serious public health ... -
Molecular mechanisms of CD8+ T cell mediated control of HIV-1 infection in peripheral blood and lymphoid tissues.
(2019)Naturally induced CD8+ T cells do not clear human immunodeficiency virus (HIV) infection, partly because the virus rapidly escapes CD8+ T cell responses and the effector cells are excluded from HIV reservoirs sites. However, ... -
Molecular modeling studies on HIV-1 inhibitors and their potential use as anticancer agents.
Acquired Immunodeficiency Syndrome (AIDS), currently regarded as one of the deadliest diseases, is a disease of the human immune system caused by the Human Immunodeficiency Virus (HIV). This dissertation addresses two ... -
Molecular modeling studies on HIV-1 Reverse Transcriptase (RT) and Heat shock protein (Hsp) 90 as a potential anti-HIV-1 target.
(2015)Human immunodeficiency virus (HIV) infection is the leading cause of death globally. This dissertation addresses two HIV-1 target proteins namely, HIV-1 Reverse Transcriptase (RT) and Heat shock protein (Hsp) 90. More ... -
Molecular profile of gram-negative ESKAPE pathogens from Komfo Anokye Teaching Hospital in Ghana.
(2017)Gram-negative ESKAPE (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp) pathogens are a major healthcare concern globally due to their ... -
Multipolymeric monolayered mucoadhesive films for drug therapy.
(2007)The use of the oral cavity membranes as sites of drug administration has been a topic of increasing interest for the past decade. The buccal route, in particular, offers several advantages over the per oral route and may ... -
Muscle damage and inflammation following a three-day trail run.
(2012)Introduction The physiological effects of single and multiday road running races have been studied extensively and include the occurrence of rhabdomyolysis, reflected by significantly increased urinary myoglobin (uMb), ... -
Naringin reversal of some aspects of diabetic nephropathy in rats type 1 streptozotocin induced diabetes.
The role of naringin on streptozotocin-induced diabetic nephropathy was investigated. Male Wister rats (200-300 g) were divided into six groups (n=7). Group A was treated with a vehicle (0.2 ml of 0.1M citrate buffer pH4.5) ...