College of Health Sciences: Recent submissions
Now showing items 1-20 of 1698
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Single cell ribonucleic acid sequencing in Tuberculosis research.
(2021)Tuberculosis (TB) remains a global challenge, with approximately 1,5 million deaths annually. Addressing deficits in our understanding of disease pathology and treatment is needed for the development of new treatment ... -
Activation of silent biosynthetic gene clusters and profiling of secondary metabolites secreted by Endophytic Fungi for use as potential anti-HIV agents.
(2022)The continuous burden of Human Immunodeficiency Virus-1 in Sub-Saharan Africa, coupled with the inability of antiretroviral agents to eradicate HIV-1 from viral reservoirs, the potential risks of drug resistance development, ... -
The clinical and angiographic profile of very young patients with coronary artery disease.
(2016)Overview of thesis in a PDF. -
Effect of hybrid immunity on the neutralizing antibody response to emerging SARS-CoV-2 variants including in people living with HIV.
(2022)This work focused on the effect of SARS-CoV-2 variants and co-infection with HIV on the neutralizing antibody response elicited by SARS-CoV-2 infection and vaccination. The first study described the effect of HIV status ... -
The clinical spectrum and outcome of skin conditions in patients admitted to dermatology wards at King Edward VIII Hospital, Durban.
(2016)Overview of theses in a PDF. -
Effect of HIV status and suppression on SARS-CoV-2 disease severity, vaccine response, and evolution.
(2023)SARS-CoV-2 is a global pandemic that has infected 672,115,430 people globally (https://coronavirus.jhu.edu/map.html, accessed 08.02.2023). SARS-CoV-2 is continuously evolving, and new variants pose a continuous threat ... -
Epidemiology and alternative approaches for SARS-CoV-2 testing within limited resources settings.
(2023)Background: In the context of the global battle to contain the rapidly mutating SARS-CoV-2, diagnostic testing for SARS-CoV-2 infection remains a challenge, particularly in low-middleincome countries (LMICs) due to low ... -
The role of specific adhesins in the regulation of other adhesin genes associated with Mycobacterium tuberculosis pathogenicity.
(2022)Background/Aim: Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), remains one of the most common causes of death throughout the world. The lack of rapid diagnostics, effective vaccines, and drugs ... -
Investigating the association between diet-induced “leaky gut” and the development of prediabetes.
(2023)Introduction Type 2 diabetes (T2D) is the most common type of diabetes mellitus, which is reported to be associated with life-threatening co-morbidities. This condition is characterized by hyperglycaemia due to a defect of ... -
The association between incretin hormones concentrations and the development of diet-induced Prediabetes.
(2023)The increase in the prevalence of type two diabetes mellitus(T2DM) is attributed to unhealthy lifestyles and high-calorie diets. T2DM is a chronic metabolic condition characterised by impaired insulin function and high ... -
Prevalence, phenotypic and genotypic characterization of resistant clinical gram-negative isolates at Kamuzu Central Hospital, Lilongwe Malawi.
(2022)nterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE) pathogens are the leading cause of nosocomial infections worldwide. They ... -
Comparison of SARS-CoV-2 sequencing using the ONT GridION and the Illumina MiSeq.
(2022)Corona Virus Disease 2019 (COVID-19) is an ongoing pandemic that has spread rapidly around the world and has seen over 431 000 000 identified cases and 5 930 000 deaths caused by this disease by the end of January 2022. ... -
A study of the effects of exercise therapy on the comorbidity of attention deficit hyperactivity disorder (ADHD) and developmental co-ordination disorder (DCD).
(2019)Background: The literature suggests a high prevalence of comorbid ADHD and DCD in South Africa and worldwide. Specific figures of the suspected high prevalence are not available and the link between the two conditions are ... -
Central nervous system (CNS) derived human immunodeficiency virus type 1 (HIV-1) subtype C long terminal repeat (LTR) genetic and functional variation mediates high viral load in this compartment of tuberculous meningitis (TBM) co-infected patients.
(2023)Background: Human immunodeficiency virus type 1 (HIV-1) ribonucleic acid (RNA) is characteristically lower in the central nervous system (CNS) than in plasma of antiretroviral treatment naïve patients. Paradoxically, ... -
Implementation of an efficient sample pooling strategy for high throughput diagnostic testing of Severe Acute Respiratory Syndrome Corona Virus-2.
(2022)The rapid identification and isolation of infected individuals remains a key strategy for controlling the spread of SARS-CoV-2. Frequent testing of populations to detect infection early in asymptomatic or presymptomatic ... -
Rehabilitation service in the northern KwaZulu-Natal, uThungulu and service providers’ knowledge and attitudes towards public private partnerships.
(2018)Rehabilitation assists persons with disabilities attain physical independence and self-determination. In South Africa, the distribution of rehabilitation services is largely poor. Rehabilitation services in uThungulu ... -
Investigating Genetic Predisposition to Gestational Diabetes Mellitus Among Black Women Residing eThekwini, KwaZulu-Natal, South Africa.
(2023)Gestational Diabetes Mellitus (GDM) is regarded as a “silent killer” determined by an abnormal glucose tolerance firstly recognised at any time during pregnancy and disappear after delivery. Carrying a large baby (>4000g), ... -
The influences of paternal prenatal chronic stress on offspring selected metabolic, behavioural and neurochemistry changes.
(2022)Exposure to past stress and trauma during early developmental stages can permanently affect the performance and advancements of core systems in humans. Whilst many studies are investigating the lasting effects of maternal ... -
Respiratory patterns and cytokine profiles among recreational athletes and a sedentary group.
(2021)Background: An increasing trend in sedentary lifestyles and physical inactivity has contributed to a higher incidence of obesity, a major health concern. Despite the fact that a sedentary lifestyle poses a considerable ... -
A Biochemical assessment of the potential of Spirulina Platensis to Ameliorate the adverse effects of highly active Antiretroviral therapy In Vitro.
(2022)The human immunodeficiency virus (HIV) has been one of the prevalent causes of diseases on a global scale over four decades of its emergence. It is estimated that about 37.7 million people are infected with HIV globally, ...