Now showing items 1-10 of 23
The role of the protease cleavage sites in viral fitness and drug resistance in HIV-1 subtype C.
There is an increasing number of patients failing second line highly active antiretroviral therapy (AZT, DDI and LPV/r) in South Africa, where HIV-1 subtype C predominates. Mutations at gag cleavage sites (CS) have ...
The use of machine learning to improve the effectiveness of ANRS in predicting HIV drug resistance.
BACKGROUD HIV has placed a large burden of disease in developing countries. HIV drug resistance is inevitable due to selective pressure. Computer algorithms have been proven to help in determining optimal treatment for ...
Minority HIV-1 drug resistance mutations in patients failing highly active antiretroviral therapy (HAART).
Abstract not available.
Light forge : a microfluidic high throughput platform for rapid and affordable detection of drug resistant strains of tuberculosis.
Tuberculosis is one of the most deadly infectious diseases currently plaguing the global community. Unfortunately, lack of accessible, reliable and affordable diagnostic tools in the high disease burden, and resource poor ...
Fitness of multi-and extensively drug-resistant mycobacterium tuberculosis clinical strains.
The biological fitness of a pathogen is defined as its ability to reproduce, survive, cause disease and be transmitted. Drug-resistant M. tuberculosis isolates often exhibit reduced competitive ability against susceptible ...
Glucocorticosteroid receptor characteristics of peripheral blood mononuclear cells in oral steroid dependent asthma : utilization of an in vitro model of steroid resistant asthma to investigate mechanisms of resistance and functional consequences of altered receptor affinity.
Background: Although glucocorticoids are the most effective treatment for asthma, some patients show a poor response. In such patients with steroid resistant asthma, this has been ascribed to altered glucocorticoid ...
Knowledge, attitude and perception of 4th and 5th year UKZN medical school students towards the use of HIV drug resistance interpretation algorithms.
HIV drug resistance (HIVDR) has emerged as a major clinical and public health challenge in many resource poor countries especially in Africa. HIVDR testing has become increasingly important and is of significant value in ...
The demographic and microbiological profile of cystic fibrosis in public and private sectors in KwaZulu-Natal.
Abstract available in hard copy.