Browsing by Advisor "Mabandla, Musa Vuyisile."
Now showing items 1-18 of 18
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The alteration of dopamine receptors in L-DOPA (L-3,4-dihydroxyphenylalanine) induced dyskinesias.
(2021)L-3,4-dihydroxyphenylalanine (L-DOPA) can ease symptoms of Parkinson’s disease (PD), butextended use of L-DOPA causes abnormal involuntary movements (AIMs) called L-DOPA induced dyskinesias (LIDs). The present study aims ... -
Alzheimer’s disease dementia risk in post-traumatic stress disorder: identification of common underlying mechanisms using rat models.
(2021)Post-traumatic stress disorder (PTSD) is a neuropsychiatric disorder that can develop from exposure to a trauma. Studies have shown that people who have PTSD are susceptible to developing dementia, mostly Alzheimer’s ... -
Characterising epigenetic alterations following cocaine consumption.
(2017)Complementary data from clinical and animal research have converged on the hypothesis that persistent use of psychostimulant drugs such as cocaine may not only involve pathological alterations in neural processes that ... -
Comparison of the effects of oral and transdermal adminstration of chloroquine on selected haematological parameters and inflammatory cytokines in P.berghei- infected male Sprague-Dawley rats.
(2016)Introduction Chloroquine (CHQ), the mainstay antimalarial drug accumulates in organs and alters physiological function. Hypoglycaemia, impairment of kidney function and anaemia are among an array of pathophysiological ... -
Developmental methylmercury toxicity in a 6- hydroxydopamine Parkinsonian rat model: evaluating Searsia chirindensis as a potential neuroprotectant.
(2017)Methylmercury (MeHg) pollution in South Africa has escalated due to increased demand from industrial sources such as coal-fired power stations. This had led to a growing interest in the effects of this metal toxin on ... -
Effect of highly active antiretroviral therapy (HAART) on HIV-1 tat protein-induced neurotoxicity.
(2014)Background: HIV-1-trans-activating (Tat) protein has been associated with development of HIV associated neurocognitive disorder (HAND). Previous studies have demonstrated that Tat protein causes neurotoxicity through an ... -
Effects of antipsychotic dose reduction on metabolic syndrome in patients with first episode psychosis treated with a long-acting injectable antipsychotic.
(2019)Background: The introduction of antipsychotics has been a significant milestone in the treatment of schizophrenia. However, these agents have several important side effects, such as metabolic syndrome. Options to curb these ... -
The effects of rhoicissus tridentate dichloromethane extract and its bioactive compounds on uterotonic and glucose lowering activity in-vitro.
(2019)Poor myometrial contractility during labour is associated with an extended partuition process that can affect the neonate’s health status. Chronic use of conventional treatments for diabetes mellitus is sometimes associated ... -
The effects of vasopressin and oxytocin on methamphetamine : induced place preference behaviour in rats.
(2012)Methamphetamine is a highly addictive stimulant drug whose illicit use and resultant addiction has become an alarming global phenomenon. The mesolimbic dopaminergic system in the brain, originating in the ventral tegmental ... -
Evaluating a new drug to combat Alzheimer's disease.
(2014)Alzheimer’s disease (AD), a progressive neurodegenerative disorder that affects mostly the limbic system and the neocortical areas of the brain, is the most prevalent form of dementia affecting the elderly population. ... -
The experiences and social factors influencing the behavior of incarcerated rapists in a male prison in KwaZulu-Natal, South Africa.
(2022)Introduction: South Africa is amongst the leading countries in the world to record high rate of sexual violence against women and children. South Africa has been labelled “the rape capital of the world” with 116 rape ... -
Fungal endophytes: isolation, identification and assessment of bioactive potential of their natural products.
(2017)Fungal endophytes produce a broad variety of bioactive compounds with potential to address some of the unmet human needs. Medicinal plants have an important role to play in the search for new strains of endophytes ... -
The influences of paternal prenatal chronic stress on offspring selected metabolic, behavioural and neurochemistry changes.
(2022)Exposure to past stress and trauma during early developmental stages can permanently affect the performance and advancements of core systems in humans. Whilst many studies are investigating the lasting effects of maternal ... -
PreNatal nicotine exposure and maternal separation alter the nicotinic acetylcholine receptors in mice.
(2019)Maternal cigarette smoking during pregnancy has been associated with long term cognitive dysfunction. The harmful behavioural effects of cigarette smoking have been shown to be primarily due to nicotine. While the mechanism ... -
Prenatal stress and febrile seizures effects on the epigenetic mechanisms involved in cognitive function following treatment with Searsia chirindensis.
(2016)Febrile seizures are of growing concern in the health fraternity within the African continent. These seizures predominantly affect children between the ages of 3 months and 5 years of age. Stress during pregnancy may ... -
Role of neuroinflammation in an amyloid-beta model of Alzheimer’s disease and the identification of possible biomarker.
(2020)Introduction. Alzheimer's disease (AD) is the most common form of neurodegenerative disorder that results in dementia. It currently affects 75 million people worldwide and is predicted to affect as many as 135 million ... -
The role of neuroinflammation, serotonin deficiency and gene expression in the pathology of L-dopa-induced dyskinesia with prolonged Levodopa treatment in a Parkinsonian rat model.
(2023)Parkinson’s disease (PD) is a neurodegenerative disorder, which globally affects 2% of the population above 65 years old. It is characterized by motor symptoms (bradykinesia, tremor, and rigidity) and nonmotor symptoms ... -
Tat protein induced neurocognitive dysfunction.
(2013)Human immunodeficiency virus type 1 (HIV-1) is a major health threat in South Africa. Studies have shown that HIV affects the central nervous system (CNS), and can initiate a progressive neurodegenerative process culminating ...