Browsing by Advisor "Abdool Karim, Salim Safurdeen."
Now showing items 1-20 of 212
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Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline Ig gene repertoire.
(American Association of Immunologists., 2015)Abstract available in pdf. -
Acceptability of early antiretroviral therapy among South African women.
(Springer., 2018)Abstract available in pdf. -
Achieving the health Millennium Development Goals for South Africa : challenges and priorities.
(Elsevier., 2009)15 years after liberation from apartheid, South Africans are facing new challenges for which the highest calibre of leadership, vision, and commitment is needed. The effect of the unprecedented HIV/AIDS epidemic has been ... -
Adaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure.
(Elsevier., 2009)It is unresolved whether recently transmitted human immunodeficiency viruses (HIV) have genetic features that specifically favour their transmissibility. To identify potential “transmission signatures”, we compared 20 ... -
An adaptive design to bridge the gap between phase 2b/3 microbicide effectiveness trials and evidence required for licensure.
(Sage., 2012)Background. Vaginally and rectally applied microbicides are being developed to help prevent sexual acquisition of HIV. Due to the lack of surrogate outcomes, the path toward licensure typically moves directly from expanded ... -
Addressing challenges in scaling up TB and HIV treatment integration in rural primary healthcare clinics in South Africa (SUTHI): a cluster randomized controlled trial protocol.
(Implementation Science., 2015)Abstract available in pdf. -
Adherence in the CAPRISA 004 tenofovir gel microbicide trial.
(Springer., 2014)High adherence is key to microbicide effectiveness. Here we provide a description of adherence interventions and the adherence rates achieved in the CAPRISA 004 Tenofovir Gel Trial. Adherence support for the before-and-after ... -
An AIDS-Free Generation?
(American Association for the Advancement of Science., 2012)No abstract available. -
Amino acid changes in the HIV-1 gp41 membrane proximal region control virus neutralization sensitivity.
(Elsevier., 2016)Abstract available in pdf. -
Anaemia in acute HIV-1 Subtype C infection.
(Plos., 2007)Background: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin ... -
Antibody maturation in women who acquire HIV infection while using antiretroviral pre-exposure prophylaxis.
(Oxford University Press., 2015)Abstract available in pdf. -
Antiretroviral prophylaxis for HIV prevention reaches a key milestone.
(Elsevier., 2012)No abstract available. -
Antiretroviral prophylaxis: a defining moment in HIV control.
(Elsevier., 2011)No abstract available. -
Antiretroviral therapy : challenges and options in South Africa.
(Elsevier., 2003)No abstract available. -
APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4R T-cell counts and plasma viral load.
(Lippincott Williams & Wilkins., 2008)Objectives: In the absence of HIV-1 virion infectivity factor (Vif), cellular cytosine deaminases such as apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) inhibit the virus by inducing ... -
Assessing adherence in the CAPRISA 004 tenofovir gel HIV prevention trial: results of a nested case–control study.
(Springer., 2014)Abstract available in pdf. -
Assessing progress with HIV incidence in national cohorts.
(Elsevier., 2017)Abstract available in pdf. -
Assessing the implementation effectiveness and safety of 1% tenofovir gel provision through family planning services in KwaZulu-Natal, South Africa: study protocol for an open-label randomized controlled trial.
(BioMed Central., 2014)Background: The Centre for the AIDS Programme of Research in South Africa (CAPRISA) 004 trial demonstrated a 39% reduction in HIV infection, with a 54% HIV reduction in women who used tenofovir gel consistently. A confirmatory ... -
Association of HIV-Specific and Total CD8+ T Memory Phenotypes in Subtype C HIV-1 Infection with Viral Set Point.
(The American Association of Immunologists, Inc., 2009)Understanding early immunological events during HIV-1 infection that may set the course of disease progression is important for identifying correlates of viral control. This study explores the association of differentiation ...