Browsing by Author "Dezzutti, Charlene S."
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Item HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 specificities.(Public Library of Science., 2014) Seaton, Kelly E.; Ballweber, Lamar.; Lan, Audrey.; Donathan, Michele.; Hughes, Sean.; Vojtech, Lucia.; Moody, Michael Anthony.; Liao, Hua-Xin.; Haynes, Barton F.; Galloway, Christine G.; Richardson, Barbra Ann.; Abdool Karim, Salim Safurdeen.; Dezzutti, Charlene S.; McElrath, Margaret Juliana.; Tomaras, Georgia D.; Hladik, Florian.Abstract available in pdf.Item Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial.(Oxford University Press on behalf of the Infectious Diseases Society of America., 2012) Dezzutti, Charlene S.; Richardson, Barbra Ann.; Marrazzo, Jeanne M.; Tugetman, Jessica.; Ramjee, Gita.; Taha, Taha E.; Chirenje, Zvavahera Mike.; Abdool Karim, Salim Safurdeen.; Hillier, Sharon Louise.; Herold, Betsy C.The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HβD-2 (odds ratio [OR], 2.39; P = .005) and greater Escherichia coli bactericidal activity (OR, 1.22; P = .01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P = .02) and may be a biomarker for HIV-1 acquisition.Item Y chromosome and HIV DNA detection in vaginal swabs as biomarkers of semen and HIV exposure in women.(Wolters Kluwer., 2014) Penrose, Kerri J.; Richardson, Barbra Ann.; Besson, Guillaume.; Dezzutti, Charlene S.; Herold, Betsy C.; Abdool Karim, Salim Safurdeen.; Mellors, John W.; Parikh, Urvi M.Abstract available in pdf.