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dc.creatorRamjee, Gita.
dc.creatorWilliams, Brian G.
dc.creatorGouws, Eleanor.
dc.creatorVan Dyck, Eddy.
dc.creatorDe Deken, Benedicte.
dc.creatorAbdool Karim, Salim Safurdeen.
dc.date.accessioned2013-05-21T08:39:04Z
dc.date.available2013-05-21T08:39:04Z
dc.date.created2004
dc.date.issued2004
dc.identifier.citationRamjee, G., et al. 2005. The impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa. J Acquir Immune Defic Syndr 39(3) pp. 333–339.en
dc.identifier.issn1525-4135
dc.identifier.urihttp://hdl.handle.net/10413/8946
dc.description.abstractThis study investigated the impact of prevalent and incident HSV-2 infection on the incidence of HIV-1 infection in a cohort of female commercial sex workers in KwaZulu-Natal, South Africa. Prior to a vaginal microbicide trial, 416 women were screened for antibodies to HIV-1 and herpes simplex virus-2 (HSV-2) infections and a questionnaire was used to establish behavioral, social, and demographic characteristics. A total of 187 HIV-1-seronegative women were followed up at monthly intervals when blood was drawn and used to detect HIV-1 and HSV-2 antibodies. The median duration of follow-up was 2.2 years. At screening 50% of the women were HIV-1 seropositive and 84% were HSV-2 seropositive. The hazards of HIV-1 among women who were HSV-2 seropositive or seronegative throughout, or among those who seroconverted during the study, were not significantly different. When HSV-2 seroconversion was analyzed as a time-dependent covariate, the hazard ratio for HIV-1 seroconversion was 6.0 (95% CI: 2.6–14.0) times greater among women with incident than among women with prevalent HSV-2 infections. Drawing on other recent studies these data suggest that incident HSV-2 infection increases the risk of HIV-1 infection; the effect wanes with time since infection; and the effect is significantly greater for men than it is for women.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkins.en
dc.subjectAIDS (Disease)--Epidemiology.en
dc.subjectHIV infections--Epidemiology.en
dc.subjectHerpes simplex virus.en
dc.subjectProstitutes--Diseases--South Africa.en
dc.subject.otherSex workers.en
dc.titleThe impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa.en
dc.typePeer reviewed journal articleen


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