Now showing items 1-6 of 6
The development of assays for atractyloside and its localisation in rat tissue.
An extract of the tuber of Callilepis laureola is regarded as the source of a powerful therapeutic agent, known as Impila. Its use is associated with fatal hepatic and renal necrosis, the renal toxin being atractyloside ...
Type IV collagenase and cathepsins L and H : proteinases involved in tumour invasion.
The collagenolytic proteinases, type IV collagenase and cathepsins Land H, have been implicated in tumour invasion and metastasis, by virtue of their degradative action on the extracellular matrix barriers traversed by ...
Trypanopain : a possible target for anti-trypanosomal agents?
The protozoan parasite Trypanosoma brucei brucei causes nagana in cattle and is a widely used model for human sleeping sickness. The major lysosomal cysteine proteinases (trypanopains) of African trypanosomes may contribute ...
A study of proteinases of invasive cells using cryoultramicrotomy and immunogold labelling.
This study forms part of an investigation into the possible relevance of the lysosomal proteinases, cathepsins B, H, Land D, in cancer cell invasion. In this study, the main technique adopted was the Tokuyasu "cryo" ...
Making sense of mixtures : chromatographic separations of plant, insect and microbial biomolecules.
No abstract available.
A study of the proteinase, cathepsin L, in the context of tumour invasion.
The proteinase, cathepsin L, has been strongly implicated in the processes of tumour invasion and metastasis. A new purification method, three-phase partitioning, characterised in terms of the parameters which affected its ...