Initiating antiretrovirals during tuberculosis treatment: a drug safety review.

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dc.creator Gengiah, Tanuja N.
dc.creator Gray, Andrew L.
dc.creator Naidoo, Kogieleum.
dc.creator Abdool Karim, Quarraisha.
dc.date.accessioned 2012-11-15T07:03:22Z
dc.date.available 2012-11-15T07:03:22Z
dc.date.created 2011
dc.date.issued 2011
dc.identifier.citation Gengia T. N., et al. 2011. Initiating antiretrovirals during tuberculosis treatment : a drug safety review. Expert Opin Drug Saf [Early online] 10, pp. 1-16. en
dc.identifier.issn 1474-0338
dc.identifier.uri http://dx.doi.org/10.1517/14740338.2011.546783 en
dc.identifier.uri http://hdl.handle.net/10413/7855
dc.description.abstract Introduction: Integrating HIV and tuberculosis (TB) treatment can reduce mortality substantially. Practical barriers to treatment integration still exist and include safety concerns related to concomitant drug use because of drug interactions and additive toxicities. Altered therapeutic concentrations may influence the chances of treatment success or toxicity. Areas covered: The available data on drug--drug interactions between the rifamycin class of anti-mycobacterials and the non-nucleoside reverse transcriptase inhibitor and the protease inhibitor classes of antiretrovirals are discussed with recommendations for integrated use. Additive drug toxicities, the impact of immune reconstitution inflammatory syndrome (IRIS) and the latest data on survival benefits of integrating treatment are elucidated. Expert opinion: Deferring treatment of HIV to avoid drug interactions with TB treatment or the occurrence of IRIS is not necessary. In the integrated management of TB--HIV co-infection, rational drug combinations aimed at reducing toxicities while effecting TB cure and suppressing HIV viral load are possible. en
dc.language.iso en en
dc.publisher Informa UK, Ltd. en
dc.subject Drug interactions. en
dc.subject HIV infections--Treatment. en
dc.subject Tuberculosis--Treatment. en
dc.subject.other HAART. en
dc.subject.other Rifamycins. en
dc.title Initiating antiretrovirals during tuberculosis treatment: a drug safety review. en
dc.type Peer reviewed journal article en

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