Interleukin-10 Promoter Polymorphisms Influence HIV-1 Susceptibility and Primary HIV-1 Pathogenesis.

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dc.creator Naicker, Dshanta D.
dc.creator Werner, Lise.
dc.creator Kormuth, Emil.
dc.creator Passmore, Jo-Ann.
dc.creator Mlisana, Koleka.
dc.creator Abdool Karim, Salim Safurdeen.
dc.creator Ndung'u, Thumbi.
dc.date.accessioned 2012-11-14T08:04:41Z
dc.date.available 2012-11-14T08:04:41Z
dc.date.created 2008
dc.date.issued 2009
dc.identifier.citation Naicker D.D., Werner L., Kormuth E., et al. 2009. Interleukin-10 promoter polymorphisms influence HIV-1 susceptibility and primary HIV-1 pathogenesis. J Infect Dis 200, pp.448–452. en
dc.identifier.issn 1537-6613
dc.identifier.uri http://dx.doi.org/10.1086/600072 en
dc.identifier.uri http://hdl.handle.net/10413/7846
dc.description.abstract Interleukin (IL)–10 directly inhibits human immunodeficiency virus type 1 (HIV-1) replication, but it may also promote viral persistence by inactivation of effector immune mechanisms. Here, we show in an African cohort that individuals with genotypes associated with high IL-10 production at 2 promoter single-nucleotide polymorphisms ( 1082 and 592) were less likely to become HIV-1 infected but had significantly higher median plasma viral loads during the acute phase ( 3 months after infection). However, as the infection progressed, the association between genotype and median viral load was reversed. Thus, IL-10 may influence HIV-1 susceptibility and pathogenesis, but effects on the latter may differ according to the infection phase. en
dc.language.iso en en
dc.publisher The Infectious Diseases Society of America. en
dc.subject Interleukin-10. en
dc.subject HIV infections--Genetic aspects. en
dc.title Interleukin-10 Promoter Polymorphisms Influence HIV-1 Susceptibility and Primary HIV-1 Pathogenesis. en
dc.type Peer reviewed journal article en

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