Recent Submissions

  • Vertical T cell immunodominance and epitope entropy determine HIV-1 escape. 

    Liu, Michael K. P.; Hawkins, Natalie.; Ritchie, Adam J.; Ganusov, Vitaly.; Whale, Victoria.; Brackenridge, Simon.; Li, Hui.; Pavlicek, Jeffrey W.; Cai, Fangping.; Abrahams, Melissa-Rose.; Treurnicht, Florette.; Hraber, Peter.; Riou, Catherine.; Gray, Clive M.; Ferrari, Guido.; Tanner, Rachel.; Ping, Li-Hua.; Anderson, Jeffrey A.; Swanstrom, Ronald.; Cohen, Myron.; Abdool Karim, Salim Safurdeen.; Haynes, Barton F.; Borrow, Persephone.; Perelson, Alan S.; Shaw, George M.; Hahn, Beatrice H.; Williamson, Carolyn.; Korber, Bette T.; Gao, Feng.; Self, Steven G.; McMichael, Andrew.; Goonetilleke, Nilu. (American Society for Clinical Investigation., 2012)
    HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide information on which parameters are most important ...
  • Challenges of diagnosing acute HIV-1 subtype C infection in African women: performance of a clinical algorithm and the need for point-of-care nucleic-acid based testing. 

    Mlisana, Koleka.; Sobieszczyk, Magdalena E.; Werner, Lise.; Feinstein, Addi.; Van Loggerenberg, Francois.; Naicker, Nivashnee.; Williamson, Carolyn.; Garrett, Nigel. (Plos., 2012)
    Background. Prompt diagnosis of acute HIV infection (AHI) benefits the individual and provides opportunities for public health intervention. The aim of this study was to describe most common signs and symptoms of AHI, ...
  • Role of education in HIV clinical outcomes in a tuberculosis endemic setting. 

    Cohen, Gabriel M.; Werner, Lise.; Gengiah, Santhanalakshmi.; Naidoo, Kogieleum. (Sage., 2013-05-24)
    This study evaluated how educational attainment impacts clinical outcomes of HIV-positive patients in Durban, South Africa. The authors conducted a prospective study of 466 adult HIV-positive patients initiating antiretroviral ...
  • Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization. 

    Georgiev, Ivelin S.; Doria-Rose, Nicole A.; Zhou, Tongqing.; Do Kwon, Young.; Staupe, Ryan P.; Moquin, Stephanie.; Chuang, Gwo-Yu.; Louder, Mark K.; Schmidt, Stefan D.; Altae-Tran, Han R.; Bailer, Robert T.; McKee, Krisha.; Nason, Martha.; O'Dell, Sijy.; Ofek, Gilad.; Pancera, Marie.; Srivatsan, Sanjay.; Shapiro, Lawrence.; Connors, Mark.; Migueles, Stephen A.; Morris, Lynn.; Nishimura, Yoshiaki.; Martin, Malcolm A.; Mascola, John R.; Kwong, Peter D. (American Association for the Advancement of Science., 2013-05-10)
    Serum characterization and antibody isolation are transforming our understanding of the humoral immune response to viral infection. Here, we show that epitope specificities of HIV-1–neutralizing antibodies in serum can be ...
  • The changing epidemiology of HIV in 2013. 

    Beyrer, Chris.; Abdool Karim, Quarraisha. (Lippincott Williams & Wilkins., 2013-07)
    Purpose of review. We sought to review the recent epidemiology of HIV-1 and to identify emerging challenges in HIV surveillance and epidemic control. Recent findings. There is increasing evidence that HIV epidemics are ...
  • The global HIV epidemic: current status and challenges. 

    Abdool Karim, Quarraisha. (Current Medicine Group., 2013-06)
    Three decades after the first reported cases of AIDS we have within our reach sufficient evidence to substantially alter the HIV epidemic at a country level regardless of mode of transmission of HIV. There are a growing ...
  • Topical microbicides - What's new? 

    Abdool Karim, Quarraisha.; Baxter, Cheryl.; Abdool Karim, Salim Safurdeen. (Lippincott Williams & Wilkins., 2013-07-01)
    Topical microbicides are an important, promising but complex HIV prevention technology under development. After 11 disappointing effectiveness trial outcomes of 6 candidate products (some tested as multiple doses and ...
  • Adherence challenges with drugs for pre-exposure prophylaxis to prevent HIV infection. 

    Gengiah, Tanuja N.; Moosa, Atika.; Naidoo, Anushka.; Mansoor, Leila E. (Springer Verlag., 2013-10)
    Background: There are 34 million people living with human immunodeficiency virus (HIV) worldwide and each year this number increases. Until a vaccine is discovered, the prevention of new HIV infections remains an urgent ...
  • Community-based intervention is necessary for the control of HIV in North-Central Nigeria. 

    Ajoge, Hannah O.; Yende Zuma, Nonhlanhla.; Jatau, Edward D.; Ibrahim, Sani.; Olonitola, Stephen O.; Shittu, Oladapo S. (Elsevier., 2013-04)
    Objectives: To determine factors associated with the observed high prevalence of HIV in North-Central Nigeria. Methods: In a cross-sectional multisite study conducted in 2007, behavioral, medical, and demographic data ...
  • Does participation in an HIV vaccine efficacy trial affect risk behaviour in South Africa? 

    Gray, Glenda E.; Metch, Barbara.; Churchyard, Gavin J.; Mlisana, Koleka.; Nchabeleng, Maphoshane.; Allen, Mary.; Moodie, Zoe.; Kublin, James.; Bekker, Linda-Gail. (Elsevier., 2013-04-12)
    Background: Increased sexual risk behaviour in participants enrolled in HIV prevention trials has been a concern. The HVTN 503/Phambili study, a phase 2B study of the Merck Ad-5 multiclade HIV vaccine in South Africa, ...
  • Adverse events in an integrated home-based treatment program for MDR-TB and HIV in KwaZulu-Natal, South Africa. 

    Brust, James C. M.; Shah, N. Sarita.; Van der Merwe, Theo L.; Bamber, Sheila.; Ning, Numing.; Heo, Moonseong.; Moll, Anthony P.; Loveday, Marian.; Lalloo, Umesh Gangaram.; Friedland, Gerald H.; Gandhi, Neel R. (Lippincott Williams & Wilkins., 2013-04-01)
    Most patients with multidrug-resistant tuberculosis (MD R-TB) in South Africa are HIV-infected, but the safety and tolerability of co-treatment are unknown. The authors reviewed all adverse events (AEs) for patients with ...
  • Bigotry and oppressive laws in Africa drive HIV in men who have sex with men. 

    Singh, Jerome Amir. (Plos., 2013-06-18)
    No abstract available.
  • Survey of ethical dilemmas facing intensivists in South Africa in the admission of patients with HIV infection requiring intensive care. 

    Naidoo, K.; Singh, Jerome Amir.; Lalloo, Umesh Gangaram. (Health & Medical Publications Group., 2013-07)
    Background. Maturing of the burgeoning HIV epidemic in South Africa has resulted in an increased demand for intensive care. Objectives. To investigate the influence of ethical dilemmas facing South African intensivists on ...
  • Co-formulated abacavir-lamivudine-zidovudine for initial treatment of HIV infection and AIDS. 

    Shey, Muki S.; Kongnyuy, Eugene J.; Alobwede, Samuel M.; Wiysonge, Charles Shey. (The Cochrane Collaboration., 2013-03-28)
    The primary objective of this review was to evaluate the antiviral efficacy of co-formulated abacavir-lamivudine-zidovudine for initial treatment of HIV infection. The secondary objectives were to evaluate the safety and ...
  • Balancing efficiency, equity and feasibility of HIV treatment in South Africa – development of programmatic guidance. 

    Baltussen, Rob.; Mikkelsen, Evelinn.; Tromp, Noor.; Hurtig, AnneKarin.; Byskov, Jens.; Olsen, Oystein.; Baeroe, Kristine.; Hontelez, Jan A.; Singh, Jerome Amir.; Norheim, Ole F. (BioMed Central., 2013-10-09)
    South Africa, the country with the largest HIV epidemic worldwide, has been scaling up treatment since 2003 and is rapidly expanding its eligibility criteria. The HIV treatment programme has achieved significant results, ...
  • HIV disease progression in the first year after delivery among african women followed in the HPTN 046 clinical trial. 

    Watts, D. Heather.; Brown, Elizabeth R.; Maldonado, Yvonne.; Herron, Casey.; Chipato, Tsungai.; Reddy, Leanne.; Moodley, Dhayendre.; Nakabiito, Clemensia.; Manji, Karim.; Fawzi, Wafaie.; George, Kathleen.; Richardson, Paul.; Zwerski, Sheryl.; Coovadia, Hoosen Mahomed.; Fowler, Mary Glenn. (Lippincott Williams & Wilkins., 2013-11-01)
    Background: Starting lifelong antiretroviral therapy (ART) in HIV-infected pregnant women may decrease HIV progression and transmission, but adherence after delivery may be difficult, especially for asymptomatic women. We ...
  • Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes. 

    Wibmer, Constantinos Kurt.; Bhiman, Jinal N.; Gray, Elin S.; Tumba, Nancy L.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn.; Morris, Lynn.; Moore, Penny L. (Plos., 2013-10-31)
    Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how these antibodies develop remain important goals in the quest to rationally develop an HIV-1 vaccine. We previously identified a ...
  • Addressing ethical, social, and cultural issues in global health research. 

    Lavery, James V.; Green, Shane K.; Bandewar, Sunita V. S.; Bhan, Anant.; Daar, Abdallah S.; Emerson, Claudia I.; Masum, Hassan.; Randazzo, Filippo M.; Singh, Jerome Amir.; Upshur, Ross E. G.; Singer, Peter A. (Plos., 2013-08-08)
    The purpose of this paper is to encourage reflection among the global health research community and the research ethics community about how a wide range of ethical, social, and cultural (ESC) influences on the conduct, ...
  • Chest radiograph findings and time to culture conversion in patients with multidrug-resistant tuberculosis and HIV in Tugela Ferry, South Africa. 

    Brust, James C. M.; Berman, Andrew R.; Zalta, Benjamin.; Haramati, Linda B.; Ning, Yuming.; Heo, Moonseong.; Van der Merwe, Theo L.; Bamber, Sheila.; Moll, Anthony P.; Friedland, Gerald H.; Shah, N. Sarita.; Gandhi, Neel R. (Plos., 2013-09-06)
    Background: The majority of patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are co-infected with HIV, but the radiographic features of MDR-TB and their relationship with time to sputum culture ...
  • Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy. 

    Naranbhai, Vivek.; Hill, Adrian V. S.; Abdool Karim, Salim Safurdeen.; Naidoo, Kogieleum.; Abdool Karim, Quarraisha.; Warimwe, George M.; McShane, Helen.; Fletcher, Helen. (Oxford University Press., 2013-12-03)
    Background. Eight decades ago, the ratio of monocytes to lymphocytes (hereafter, the “ML ratio”) was noted to affect outcomes of mycobacterial infection in rabbits. Recent transcriptomic studies support a role for relative ...

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