Now showing items 207-226 of 229

    • TB treatment outcomes following directly-observed treatment at an urban outpatient specialist TB facility in South Africa. 

      Kharsany, Ayesha B. M.; Olowolagba, Ayo.; Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Connolly, Catherine. (Sage., 2006)
      The treatment of 450 consecutive new patients with pulmonary TB was evaluated to determine outcome following directly-observed treatment. In all,176 (39.1%) patients were cured, 23 (5.1%) completed treatment, 80 (17.8%) ...
    • TB/HIV: an orphan disease? 

      Brust, James C. M.; O'Donnell, Max R.; Metcalfe, John Z. (American Thoracic Society., 2011-06-01)
      No abstract available.
    • Temporal association of HLA-B*81:01- and HLA-B*39:10-mediated HIV-1 p24 sequence evolution with disease progression. 

      Ntale, Roman.; Chopera, Denis.; Ngandu, Nobubelo K.; de Assis Rosa, Debra.; Zembe, L.; Gamieldien, H.; Mlotshwa, Mandla.; Werner, Lise.; Woodman, Zenda.; Mlisana, Koleka Patience.; Abdool Karim, Salim Safurdeen.; Gray, Clive M.; Williamson, Carolyn. (American Society for Microbiology., 2012)
      HLA-B*81:01 and HLA-B*39:10 alleles have been associated with viremic control in HIV-1 subtype C infection. Both alleles restrict the TL9 epitope in p24 Gag, and cytotoxic-T-lymphocyte (CTL)-mediated escape mutations in ...
    • Ten-year review of research in South Africa : government is tackling the R&D crisis caused by a shift of focus to service delivery. 

      Singh, Jerome Amir. (Nature publishing Group., 2004-04-29)
      No abstract available.
    • Time for gender mainstreaming in editorial policies. 

      Heidari, Shirin.; Eckert, Mirjam J.; Kippax, Susan.; Abdool Karim, Quarraisha.; Sow, Papa Salif.; Wainberg, Mark A. (International AIDS Society., 2011)
      The HIV epidemic has been continuously growing among women, and in some parts of the world, HIV-infected women outnumber men. Women’s greater vulnerability to HIV, both biologically and socially, influences their health ...
    • Timing of initiation of antiretroviral drugs during tuberculosis therapy. 

      Abdool Karim, Salim Safurdeen.; Naidoo, Kogieleum.; Grobler, Anna Christina.; Padayatchi, Nesri.; Baxter, Cheryl.; Gray, Andrew L.; Gengiah, Tanuja N.; Nair, Gonasagrie.; Bamber, Sheila.; Singh, Aarthi.; Khan, Munira.; Pienaar, Jacqueline C.; El-Sadr, Wafaa.; Friedland, Gerald H.; Abdool Karim, Quarraisha. (Massachusetts Medical Society., 2010)
      Background. The rates of death are high among patients with coinfection with tuberculosis and the human immunodeficiency virus (HIV). The optimal timing for the initiation of antiretroviral therapy in relation to tuberculosis ...
    • Topical microbicides - What's new? 

      Abdool Karim, Quarraisha.; Baxter, Cheryl.; Abdool Karim, Salim Safurdeen. (Lippincott Williams & Wilkins., 2013-07-01)
      Topical microbicides are an important, promising but complex HIV prevention technology under development. After 11 disappointing effectiveness trial outcomes of 6 candidate products (some tested as multiple doses and ...
    • Transmission of HIV-1 CTL escape variants provides HLA - mismatched recipients with a survival advantage. 

      Chopera, Denis.; Woodman, Zenda.; Mlisana, Koleka Patience.; Mlotshwa, Mandla.; Martin, Darren P.; Seoighe, Cathal.; Treurnicht, Florette K.; de Assis Rosa, Debra.; Hide, Winston.; Abdool Karim, Salim Safurdeen.; Gray, Clive M.; Williamson, Carolyn. (Plos., 2008)
      One of the most important genetic factors known to affect the rate of disease progression in HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) locus, which determines the HIV peptides ...
    • Treatment outcomes for extensively drug-resistant tuberculosis and HIV co-infection. 

      O'Donnell, Max R.; Padayatchi, Nesri.; Kvasnovsky, Charlotte.; Werner, Lise.; Master, Iqbal.; Horsburgh, C. Robert. (U.S. National Center for Infectious Diseases., 2013-03)
      High mortality rates have been reported for patients co-infected with extensively drug-resistant tuberculosis (XDR-TB) and HIV, but treatment outcomes have not been reported. We report treatment outcomes for adult XDR TB ...
    • TRIM5α and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment. 

      Singh, Ravesh.; Patel, Vinod.; Mureithi, Marianne W.; Naranbhai, Vivek.; Ramsuran, Duran.; Tulsi, Sahil.; Hiramen, Keshni.; Werner, Lise.; Mlisana, Koleka.; Altfeld, Marcus.; Luban, Jeremy.; Kasprowicz, Victoria.; Dheda, Keertan.; Abdool Karim, Salim Safurdeen.; Ndung’u, Thumbi. (American Society for Microbiology., 2014)
      The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5α and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and ...
    • Understanding methods for estimating HIV-associated maternal mortality. 

      Rosen, James E.; De Zoysa, Isabelle.; Dehne, Karl.; Mangiaterra, Viviana.; Abdool Karim, Quarraisha. (Hindawi Publishing Corporation., 2012)
      The impact of HIV on maternal mortality and more broadly on the health of women, remains poorly documented and understood. Two recent reports attempt to address the conceptual and methodological challenges that arise in ...
    • Understanding the experiences of doctors who undertake elective surgery on HIV/AIDS patients in an area of high incidence in South Africa. 

      Gwala-Ngozo, Jacqueline Nomaswazi.; Taylor, Myra.; Aldous, Colleen. (NISC & Taylor & Francis, 2010)
      This study investigates the experiences of doctors who perform elective surgical procedures in an area of South Africa with a high incidence of HIV and AIDS. A qualitative study approach was adopted. Interviews were ...
    • Unusual presentation of extrapulmonary tuberculosis: a case report on mammary tuberculosis. 

      Khan, Munira.; Naidoo, Kogieleum. (South African Medical Association., 2011-06)
      This case study highlights an unusual manifestation of extrapulmonary tuberculosis (TB) in a person living with HIV, namely mammary TB. Clinicians practising in settings where HIV and TB are endemic need to be aware ...
    • Utility of colposcopy in a phase 2 portion of a microbicide clinical trial of BufferGel and 0.5% PRO 2000 Gel. 

      Chirenje, Zvavahera M.; Masse, Benoit.; Maslankowski, Lisa.; Ramjee, Gita.; Coletti, Anne.; Tembo, Tchangani.; Magure, Tsitsi M.; Soto-Torres, Lydia.; Kelly, Cliff.; Hillier, Sharon L.; Abdool Karim, Salim Safurdeen. (BioMed Central / International AIDS Society., 2012-07-27)
      Background: The majority of new HIV infections are acquired through heterosexual transmission. There is urgent need for prevention methods to compliment behavior change and condom use. Topical microbicide represent a ...
    • Utility of Tuberculosis directly observed therapy programs as sites for access to and provision of antiretroviral therapy in resource-limited countries. 

      Friedland, Gerald H.; Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Jack, Christopher.; Gandhi, Neel R.; El-Sadr, Wafaa.; Lalloo, Umesh Gangaram. (The Infectious Diseases Society of America., 2004-06-01)
      The overwhelming share of the global human immunodeficiency virus (HIV) infection and disease burden is borne by resource-limited countries. The explosive spread of HIV infection and growing burden of disease in these ...
    • Utilizing nucleic acid amplification to identify acute HIV infection. 

      Abdool Karim, Salim Safurdeen.; Mlisana, Koleka Patience.; Kharsany, Ayesha B. M.; Williamson, Carolyn.; Baxter, Cheryl.; Abdool Karim, Quarraisha. (Lippincott Williams & Wilkins., 2007-03-12)
      No abstract available.
    • Vertical T cell immunodominance and epitope entropy determine HIV-1 escape. 

      Liu, Michael K. P.; Hawkins, Natalie.; Ritchie, Adam J.; Ganusov, Vitaly.; Whale, Victoria.; Brackenridge, Simon.; Li, Hui.; Pavlicek, Jeffrey W.; Cai, Fangping.; Abrahams, Melissa-Rose.; Treurnicht, Florette K.; Hraber, Peter.; Riou, Catherine.; Gray, Clive M.; Ferrari, Guido.; Tanner, Rachel.; Ping, Li-Hua.; Anderson, Jeffrey A.; Swanstrom, Ronald.; Cohen, Myron.; Abdool Karim, Salim Safurdeen.; Haynes, Barton F.; Borrow, Persephone.; Perelson, Alan S.; Shaw, George M.; Hahn, Beatrice H.; Williamson, Carolyn.; Korber, Bette T.; Gao, Feng.; Self, Steven G.; McMichael, Andrew.; Goonetilleke, Nilu. (American Society for Clinical Investigation., 2012)
      HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide information on which parameters are most important ...
    • Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes. 

      Wibmer, Constantinos Kurt.; Bhiman, Jinal N.; Gray, Elin S.; Tumba, Nancy L.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn.; Morris, Lynn.; Moore, Penny L. (Plos., 2013-10-31)
      Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how these antibodies develop remain important goals in the quest to rationally develop an HIV-1 vaccine. We previously identified a ...
    • Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. 

      Chopera, Denis.; Mlotshwa, Mandla.; Woodman, Zenda.; Mlisana, Koleka Patience .; de Assis Rosa, Debra.; Martin, Darren P.; Abdool Karim, Salim Safurdeen.; Gray, Clive M.; Williamson, Carolyn. (American Society for Microbiology., 2010)
      Molecular epidemiology studies have identified HLA-B*58:01 as a protective HIV allele. However, not all B*58:01-expressing persons exhibit slow HIV disease progression. We followed six HLA-B*58:01-positive, HIV subtype ...
    • When to start antiretroviral therapy during tuberculosis treatment? 

      Naidoo, Kogieleum.; Baxter, Cheryl.; Abdool Karim, Salim Safurdeen. (Lippincott Williams & Wilkins., 2013-02)
      Purpose of review. Effective treatment exists for tuberculosis (TB) and for HIV, but treating both diseases simultaneously presents several challenges. This review assesses the evidence for the timing of antiretroviral ...