Now showing items 106-125 of 212

    • Identification of broadly neutralizing antibody epitopes in 1 the HIV-1 envelope glycoprotein using evolutionary models. 

      Lacerda, Miguel.; Moore, Penny L.; Ngandu, Nobubelo K.; Seaman, Michael.; Gray, Elin S.; Murrell, Ben.; Krishnamoorthy, Mohan.; Nonyane, Molati.; Madiga, Maphuti.; Wibmer, Constantinos Kurt.; Sheward, Daniel.; Bailer, Robert T.; Gao, Hongmei.; Greene, Kelli M.; Abdool Karim, Salim Safurdeen.; Mascola, John R.; Korber, Bette TM.; Montefiori, David C.; Morris, Lynn.; Williamson, Carolyn.; Seoighe, Cathal. (Virology Journal, 2013)
      Background: Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine. Methods: We have developed a computational ...
    • Immune evaluation of HIV-infected and noninfected pre-eclamptics. 

      Naidoo, Kalendri.; Pupuma, Xanti Bongo S.; Moodley, Jagidesa. (MedPharm, 2010-03)
      No abstract available.
    • The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trial. 

      Naidoo, Kogieleum.; Yende Zuma, Nonhlanhla.; Padayatchi, Nesri.; Naidoo, Kasavan.; Jithoo, Niraksha.; Nair, Gonasagrie.; Bamber, Sheila.; Gengiah, Santhanalakshmi.; El-Sadr, Wafaa.; Friedland, Gerald H.; Abdool Karim, Salim Safurdeen. (American College of Physicians., 2012-09-04)
      Background: Concerns about the immune reconstitution inflammatory syndrome (IRIS) remain a barrier to antiretroviral therapy (ART) initiation during antituberculosis treatment in co-infected patients. Objective: To ...
    • Impact of blood processing variations on natural killer cell frequency, activation, chemokine receptor expression and function. 

      Naranbhai, Vivek.; Bartman, Pat.; Ndlovu, Dudu.; Ramkalawon, Pamela.; Ndung'u, Thumbi.; Wilson, Douglas.; Altfeld, Marcus.; Carr, William Henry. (Elsevier for Association of Medical Laboratory Immunologists., 2011-03-07)
      Understanding the role of natural killer (NK) cells in human disease pathogenesis is crucial and necessitates study of patient samples directly ex vivo. Manipulation of whole blood by density gradient centrifugation or ...
    • The impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa. 

      Ramjee, Gita.; Williams, Brian G.; Gouws, Eleanor.; Van Dyck, Eddy.; De Deken, Benedicte.; Abdool Karim, Salim Safurdeen. (Lippincott Williams & Wilkins., 2005-07-01)
      This study investigated the impact of prevalent and incident HSV-2 infection on the incidence of HIV-1 infection in a cohort of female commercial sex workers in KwaZulu-Natal, South Africa. Prior to a vaginal microbicide ...
    • Impact of maternal and infant antiretroviral drug regimens on drug resistance in HIV-infected breastfeeding infants. 

      Fogel, Jessica M.; Mwatha, Anthony.; Brown, Elizabeth R.; Richardson, Paul.; Chipato, Tsungai.; Alexandre, Michel.; Moodley, Dhayendre.; Elbireer, Ali.; Mirochnick, Mark.; George, Kathleen.; Mofenson, Lynne M.; Zwerski, Sheryl.; Eshleman, Susan H.; Coovadia, Hoosen Mahomed. (Pediatric Infectious Disease Journal, 2013)
      Background: The HIV Prevention Trials Network (HPTN) 046 trial evaluated the efficacy of extended infant nevirapine (NVP) administration for prevention of HIV transmission through breastfeeding. Infants received daily ...
    • Implementing microbicides in low-income countries. 

      Gengiah, Tanuja N.; Abdool Karim, Quarraisha. (Elsevier., 2012)
      The magnitude of the global human immunodeficiency virus (HIV) epidemic is determined by women from lower income countries, specifically sub-Saharan Africa. Microbicides offer women who are unable to negotiate safe sex ...
    • Improved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatment in the SAPiT trial. 

      Padayatchi, Nesri.; Naidoo, Kogieleum.; Grobler, Anna Christina.; Abdool Karim, Salim Safurdeen.; Friedland, Gerald H. (International Journal of Tuberculosis and Lung Disease., 2014)
      BACKGROUND: The therapeutic effects of antiretroviral treatment (ART) in patients with multidrug-resistant tuberculosis (MDR-TB) and human immunodeficiency virus (HIV) infection have not been established. Objective : ...
    • Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for CMV-specific CD8+ T cells. 

      Riou, Catherine.; Treurnicht, Florette.; Abrahams, Melissa-Rose.; Mlisana, Koleka.; Liu, Michael K. P.; Goonetilleke, Nilu.; Koup, Richard.; Roederer, Mario.; Abdool Karim, Salim Safurdeen.; De Bruyn, Guy.; Williamson, Carolyn.; Gray, Clive M.; Burgers, Wendy A. (American Association of Immunologists., 2012-09-15)
      The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it is unclear whether the maintenance of polyfunctionality is ...
    • Increasing burden of pulmonary tuberculosis in young women. 

      Kharsany, Ayesha B. M.; Connolly, Catherine.; Olowolagba, Ayo.; Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha. (South African Medical Association / Health & Medical Publications Group., 2006-06)
      No abstract available.
    • The influence of tuberculosis treatment on efavirenz clearance in patients co-infected with HIV and tuberculosis. 

      Gengiah, Tanuja N.; Holford, Nicholas H. G.; Botha, Julia H.; Gray, Andrew L.; Naidoo, Kogieleum.; Abdool Karim, Salim Safurdeen. (Springer-Verlag., 2011)
      Purpose: Drug interactions are of concern when treating patients co-infected with human immunodeficiency virus (HIV) and tuberculosis. Concomitant use of efavirenz (EFV) with the enzyme inducer rifampicin might be expected ...
    • Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population. 

      Mamtani, Manju.; Mummidi, Srinivas.; Ramsuran, Veron.; Pham, Minh-Hieu.; Maldonado, Robert.; Begum, Kazi.; Valera, Maria Soledad.; Sanchez, Racquel.; Castiblanco, John.; Kulkarni, Hemant.; Ndung'u, Thumbi.; He, Weijing.; Anaya, Juan Manuel.; Ahuja, Sunil K. (Oxford University Press on behalf of The Infectious Diseases Society of America., 2011-06-01)
      We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)–1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The ...
    • Initial B-Cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. 

      Tomaras, Georgia D.; Yates, Nicole L.; Liu, Pinghuang.; Qin, Li.; Fouda, Genevieve G.; Chavez, Leslie L.; Decamp, Allan C.; Parks, Robert J.; Ashley, Vicki C.; Lucas, Judith T.; Cohen, Myron.; Eron, Joseph.; Hick, Charles B.; Liao, Hua-Xin.; Self, Steven G.; Landucci, Gary.; Forthal, Donald N.; Weinhold, Kent J.; Keele, Brandon F.; Hahn, Beatrice H.; Greenberg, Michael L.; Morris, Lynn.; Abdool Karim, Salim Safurdeen.; Blattner, William A.; Montefiori, David C.; Shaw, George M.; Perelson, Alan S.; Haynes, Barton F. (American Society for Microbiology., 2008)
      A window of opportunity for immune responses to extinguish human immunodeficiency virus type 1 (HIV-1) exists from the moment of transmission through establishment of the latent pool of HIV-1-infected cells. A critical ...
    • Initiating antiretrovirals during tuberculosis treatment: a drug safety review. 

      Gengiah, Tanuja N.; Gray, Andrew L.; Naidoo, Kogieleum.; Abdool Karim, Quarraisha. (Informa UK, Ltd., 2011)
      Introduction: Integrating HIV and tuberculosis (TB) treatment can reduce mortality substantially. Practical barriers to treatment integration still exist and include safety concerns related to concomitant drug use because ...
    • Innate immune activation enhances HIV acquisition in women, diminishing the effectiveness of tenofovir microbicide gel. 

      Naranbhai, Vivek.; Abdool Karim, Salim Safurdeen.; Altfeld, Marcus.; Samsunder, Natasha.; Durgiah, Raveshni.; Sibeko, Sengeziwe.; Abdool Karim, Quarraisha.; Carr, William Henry. (Oxford University Press., 2012-09-01)
      The antiretroviral agent, tenofovir, formulated as a vaginal microbicide gel, reduces human immunodeficiency virus (HIV) acquisition by 39% in women. This study assessed the role of preexisting immune activation in ...
    • Integration of antiretroviral therapy with tuberculosis treatment. 

      Abdool Karim, Salim Safurdeen.; Naidoo, Kogieleum.; Grobler, Anna Christina.; Padayatchi, Nesri.; Baxter, Cheryl.; Gray, Andrew L.; Gengiah, Tanuja N.; Gengiah, Santhanalakshmi.; Naidoo, Anushka.; Jithoo, Niraksha.; Nair, Gonasagrie.; El-Sadr, Wafaa.; Friedland, Gerald H.; Abdool Karim, Quarraisha. (Massachusetts Medical Society., 2011-10-20)
      Background. We previously reported that integrating antiretroviral therapy (ART) with tuberculosis treatment reduces mortality. However, the timing for the initiation of ART during tuberculosis treatment remains ...
    • Interleukin-10 Promoter Polymorphisms Influence HIV-1 Susceptibility and Primary HIV-1 Pathogenesis. 

      Naicker, Dshanta D.; Werner, Lise.; Kormuth, Emil.; Passmore, Jo-Ann.; Mlisana, Koleka.; Abdool Karim, Salim Safurdeen.; Ndung'u, Thumbi. (The Infectious Diseases Society of America., 2009)
      Interleukin (IL)–10 directly inhibits human immunodeficiency virus type 1 (HIV-1) replication, but it may also promote viral persistence by inactivation of effector immune mechanisms. Here, we show in an African cohort ...
    • Intersubtype differences in the effect of a rare p24 Gag mutation on HIV-1 replicative fitness. 

      Chopera, Denis.; Cotton, Laura A.; Zawaira, Alexander.; Mann, Jaclyn K.; Ngandu, Nobubelo K.; Ntale, Roman.; Carlson, Jonathan M.; Mlisana, Koleka.; Woodman, Zenda.; De Assis Rosa, Debra.; Martin, Eric.; Miura, Toshiyuki.; Pereyra, Florencia.; Walker, Bruce D.; Gray, Clive M.; Martin, Darren P.; Ndung'u, Thumbi.; Brockman, Mark A.; Abdool Karim, Salim Safurdeen.; Brumme, Zabrina L.; Williamson, Carolyn. (American Society for Microbiology., 2012-12)
      Certain immune-driven mutations in HIV-1, such as those arising in p24Gag, decrease viral replicative capacity. However, the intersubtype differences in the replicative consequences of such mutations have not been explored. ...
    • Interventions to modify sexual risk behaviours for preventing HIV in homeless youth. 

      Naranbhai, Vivek.; Abdool Karim, Quarraisha.; Meyer-Weitz, Anna. (John Wiley & Sons, Ltd., 2011)
      Background - Homeless youth are at high risk for HIV infection as a consequence of risky sexual behavior. Interventions in homeless youth are challenging. Assessment of the effectiveness of interventions to modify sexual ...
    • Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting. 

      Morris, Lynn.; Chen, Xi.; Alam, Munir.; Tomaras, Georgia D.; Zhang, Ruijun.; Marshall, Dawn.; Chen, Bing.; Parks, Robert J.; Foulger, Andrew.; Jaeger, Frederick.; Donathan, Michele.; Bilska, Mira.; Gray, Elin S.; Abdool Karim, Salim Safurdeen.; Kepler, Thomas B.; Whitesides, John.; Montefiori, David C.; Moody, M. Anthony.; Liao, Hua-Xin.; Haynes, Barton F. (Plos., 2011)
      Broadly neutralizing antibodies are not commonly produced in HIV-1 infected individuals nor by experimental HIV-1 vaccines. When these antibodies do occur, it is important to be able to isolate and characterize them to ...