Browsing Pharmaceutical Sciences by Title
Now showing items 56-74 of 74
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Organocatalyzed synthesis of carbapenem β-lactam cores and monobactam.
Organocatalysis has emerged as a new powerful methodology for the catalytic production of enantiomerically pure organic compounds. The main aim of this work was to develop organocatalyzed routes to novel β-lactam derivatives. ... -
Pharmaceutical availability on newly formulated oral sustained release pellets containing the antihistamine, chlorpheniramine maleate.
(1991)The main objective of the present study was to determine the feasibility of obtaining aqueous polymer-coated pellet formulations using EudragitR NE 30 D dispersion and chlorpheniramine maleate as the model drug. Many factors ... -
Pharmacoeconomic implications of interchangeable use of oral NSAIDS for pain management at a district hospital.
(2015)Background: Ibuprofen, diclofenac and aspirin belong to the same class of drugs called NSAIDs, but are used interchangeably at Tonga Hospital. The problem with this approach is that it may lead to preventable misguided ... -
Pharmacokinetics and pharmacodynamics of glibenclamide in type 2 diabetics.
Abstract available in PDF file. -
The pharmacokinetics of phenobarbitone in fasting and non-fasting dogs.
(1990)Practicing clinical veterinarians in large companion animal practices are often faced with the phenomena of epileptic seizures which occur commonly in dogs. The high incidence of non-responsive cases is often frustrating, ... -
The pharmacokinetics/pharmacodynamics of theophylline in premature neonates during the first few days after birth.
(2000)Theophylline is one of the few preparations available for the treatment of apnoea of prematurity. Currently little data is available on the pharmacokinetics and the pharmacokinetic/pharmacodynamic relationships of ... -
Pharmacological effects of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) Corm ("African Potato") aqueous extract on some mammalian extra-vascular smooth muscles in vitro.
(2009)Extracts of Hypoxis hemerocallidea corm (African potato) are commonly used by some traditional health practitioners in KwaZulu-Natal Province of South Africa for an array of human ailments. This study was, therefore, ... -
A retrospective analysis of subjects who have approved gastro-oesophageal reflux disease (GORD) from a private medical aid fund.
(2006)Abstract not available. -
Some pharmacological properties of Harpagophytum procumbens DC [Pedaliaceae] secondary root extract
(2004)Abstract available on PDF file. -
Studies on molluscicidal properties of some South African medicinal plants used in the control of schistosomiasis in KwaZulu-Natal.
(2002)Schistosomiasis is an important public health issue for rural communities located near,or around slow moving water bodies in the tropical and subtropical areas. Successful control of the disease involves multifaceted ... -
Studies on some pharmacological properties of Capsicum frutescens-driven capsaicin in experimental animal models.
(2012)The present study investigated pharmacological properties of Capsicum frutescens-derived capsaicin, including its analgesic, anti-inflammatory and coagulatory properties. The effects of capsaicin on gastrointestinal and ... -
A study of the relationship between the pharmacokinetics and the pharmacodynamics of atenolol in black and white subjects using an effect modelling technique.
(1991)Abstract is available in PDF file. -
Synthesis and biological activities of natural homoisoflavanones.
(2011)Plants have formed the foundation of traditional medicine systems throughout the world for thousands of years and continue to provide mankind with new remedies for various ailments. A large portion of the black South ... -
Synthesis and biological evaluation of dihydropyrimidinone derivatives as a promising antimicrobial agents.
Abstract available in PDF file. -
Synthesis and evaluation of novel tetrahydroisoquinoline organocatalysts in asymmetric catalysis.
(2012)Organocatalysis has rapidly expanded in the last decade to encompass a wide variety of small organic molecules that are capable of either activating substrates or transforming them into more reactive forms. The aim of ... -
Synthesis of novel polymeric materials for antimicrobial applications.
(2015)Abstract available in PDF file. -
The toxicological properties of Scilla nervosa (Burch.) Jessop (Hyacinthaceae) in cultured HepG2 liver cells.
(2011)Background and Aims of Study. Scilla nervosa is a member of the Hyacinthaceae plant family that has been naturalised in the grasslands of Southern Africa. The bulbs are traditionally used to treat a variety of ailments. ... -
Use of matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) to detect carbapenem-resistant Enterobacteriaceae.
Antimicrobial drug resistance is increasing worldwide at a frightening rate and is found among different species of bacteria causing nosocomial and community-acquired infections. Carbapenem-resistant Enterobacteriaceae ...
