Show simple item record

dc.contributor.advisorGerber, J. P.
dc.contributor.advisorMulholland, Dulcie A.
dc.creatorDovey, Martin Charles.
dc.date.accessioned2011-10-20T11:39:20Z
dc.date.available2011-10-20T11:39:20Z
dc.date.created2001
dc.date.issued2001
dc.identifier.urihttp://hdl.handle.net/10413/3878
dc.descriptionThesis (M.Sc.)-University of Natal, Durban, 2001.en
dc.description.abstractThe synthesis of p-lactams has been of foremost importance since the discovery of penicillin by Sir Alexander Fleming, in 1928, and its susequent structure elucidation in 1945. Ethyl N-2-bromo-alkylcarbamates show considerable potential as precursors to p- lactams. In the past, p-lactams have been prepared by many methods, none of which have involved 2-3 bond formation. The proposed ring closure using ethyl N-2-bromoalkylcarbamate involves 2-3 bond formation, making this method of synthesis novel. This work describes two attempted methods of cyclisation. The first using a Grignard reagent, and the second, using abstraction of an acidic proton a to a phosphonate group. These methods of intramolecular cyclisation were based on analogous intermolecular additions, which are also described. The second method was also used to determine the general potential of ethyl N-bromo- alkylcarbamtes as precursors to other heterocyclic systems.en
dc.description.sponsorshipNRF & NRF/DEA & T.en
dc.language.isoenen
dc.subjectEthyl bromide.en
dc.subjectUrethane.en
dc.subjectHeterocyclic compounds.en
dc.subjectBeta lactam antibiotics.en
dc.subjectSponges.en
dc.subjectSterols.en
dc.subjectOceanapia.en
dc.subjectTheses--Chemistry.en
dc.titleEthyl N-bromo-alkylcarbamates as heterocyclic precursors and extractives from Oceanapia sp.en
dc.typeThesisen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record