Now showing items 1-20 of 23

    • Case series of the long-term psychosocial impact of drug-resistant tuberculosis in HIV-negative medical doctors. 

      Padayatchi, Nesri.; Daftary, Amrita.; Moodley, T.; Madansein, R.; Ramjee, A. (International Union against Tuberculosis and Lung Disease., 2010-08-01)
      BACKGROUND: Health care workers (HCWs) are at greater risk for tuberculosis (TB), including multidrug-resistant TB (MDR-TB), compared to the general population. The psychosocial impact of nosocomial TB on HCWs has received ...
    • A community officer’s perspective of a rural hospital in KwaZulu-Natal. 

      Perumal, Rubeshan.; Padayatchi, Nesri. (South African Medical Association / Health & Medical Publications Group., 2012-06)
      No abstract available.
    • Comparing early treatment outcomes of MDR-TB in a decentralised setting with a centralised setting in KwaZulu-Natal, South Africa. 

      Loveday, Marian.; Wallengren, K.; Voce, Anna Silvia.; Margot, B.; Reddy, T.; Master, Iqbal.; Brust, James C. M.; Chaiyachati, K.; Padayatchi, Nesri. (International Union against Tuberculosis and Lung Disease., 2012-02-16)
      Setting—In KwaZulu-Natal, South Africa, a TB and HIV endemic setting, prolonged hospitalisation for the treatment of the growing number of MDR-TB patients is not possible or effective. Objective—We compared early treatment ...
    • Evaluation of time to detection of mycobacterium tuberculosis in broth culture as a determinant for end points in treatment trials. 

      Weiner, Marc.; Prihoda, Thomas J.; Burman, William.; Johnson, John L.; Goldberg, Stefan.; Padayatchi, Nesri.; Duran, Paula.; Engle, Melissa.; Muzanye, Grace.; Mugerwa, Roy D.; Sturm, A. Willem. (American Society for Microbiology., 2010)
      Development of new treatments for tuberculosis is hampered by the lack of an accurate surrogate end point and the high degree of efficacy of current 6-month regimens. Sputum culture status after 2 months of therapy, a ...
    • Expanding HIV surveillance to include TB patients in resource-limited settings with a generalized epidemic. 

      Padayatchi, Nesri.; Stiefvater, E.; Naidoo, K.; Naidoo, K.; Ndung'u, Thumbi.; Abdool Karim, Quarraisha. (International Union against Tuberculosis and Lung Disease., 2009-12-01)
      Screening of antenatal clinic attendees is central to monitoring the human immunodeficiency virus (HIV) epidemic. However, recent evidence suggests that declining fertility rates are affecting the reliability of antenatal ...
    • High treatment failure and default rates for patients with multidrug-resistant tuberculosis in KwaZulu-Natal, South Africa, 2000–2003. 

      Brust, James C. M.; Gandhi, Neel R.; Carrara, H.; Osburn, G.; Padayatchi, Nesri. (The Union., 2009)
      SETTING: Multidrug-resistant tuberculosis (MDR-TB) has emerged as a significant public health threat in South Africa. OBJECTIVE: To describe treatment outcomes and determine risk factors associated with unfavorable outcomes ...
    • HIV testing and disclosure: a qualitative analysis of TB patients in South Africa. 

      Daftary, Amrita.; Padayatchi, Nesri.; Padilla, M. (Taylor & Francis., 2007-04-13)
      In South Africa, more than 60% of TB patients have HIV co-infection. Voluntary counseling and testing (VCT) is critical to effective HIV prevention, and TB facilities are optimal venues for delivery of these services. ...
    • HIV-associated tuberculosis. 

      Naidoo, Kogieleum.; Naidoo, Kasavan.; Padayatchi, Nesri.; Abdool Karim, Quarraisha. (Hindawi Publishing Corporation., 2011)
      The intersecting HIV and Tuberculosis epidemics in countries with a high disease burden of both infections pose many challenges and opportunities. For patients infected with HIV in high TB burden countries, the diagnosis ...
    • The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trial. 

      Naidoo, Kogieleum.; Yende Zuma, Nonhlanhla.; Padayatchi, Nesri.; Naidoo, Kasavan.; Jithoo, Niraksha.; Nair, Gonasagrie.; Bamber, Sheila.; Gengiah, Santhanalakshmi.; El-Sadr, Wafaa.; Friedland, Gerald H.; Abdool Karim, Salim Safurdeen. (American College of Physicians., 2012-09-04)
      Background: Concerns about the immune reconstitution inflammatory syndrome (IRIS) remain a barrier to antiretroviral therapy (ART) initiation during antituberculosis treatment in co-infected patients. Objective: To ...
    • Integration of antiretroviral therapy with tuberculosis treatment. 

      Abdool Karim, Salim Safurdeen.; Naidoo, Kogieleum.; Grobler, Anneke.; Padayatchi, Nesri.; Baxter, Cheryl.; Gray, Andrew L.; Gengiah, Tanuja N.; Gengiah, Santhanalakshmi.; Naidoo, Anushka.; Jithoo, Niraksha.; Nair, Gonasagrie.; El-Sadr, Wafaa.; Friedland, Gerald H.; Abdool Karim, Quarraisha. (Massachusetts Medical Society., 2011-10-20)
      Background. We previously reported that integrating antiretroviral therapy (ART) with tuberculosis treatment reduces mortality. However, the timing for the initiation of ART during tuberculosis treatment remains ...
    • Lessons from a randomised clinical trial for multidrug-resistant tuberculosis. 

      Padayatchi, Nesri.; MacKenzie, W. R.; Hirsch-Moverman, Y.; Feng, P-J.; Villarino, E.; Saukkonen, J.; Heilig, Charles M.; Weiner, Marc.; El-Sadr, Wafaa. (International Union against Tuberculosis and Lung Disease., 2012-12-01)
      BACKGROUND: The treatment of multidrug-resistant tuberculosis (MDR-TB) is currently based upon expert opinion and findings from case series, rather than upon randomised clinical trials (RCTs). OBJECTIVE: To describe the ...
    • Managing multiple and extensively drug-resistant tuberculosis and HIV. 

      Padayatchi, Nesri.; Friedland, Gerald H. (Informa Healthcare., 2007)
      Global increases in multi-drug-resistant and extensively drug-resistant tuberculosis (TB), are threatening both TB and HIV treatment programs worldwide. Together, they raise concerns of a global epidemic of untreatable TB. ...
    • Multidrug-resistant Tuberculous Meningitis in KwaZulu-Natal, South Africa. 

      Patel, V. B.; Padayatchi, Nesri.; Bhigjee, Ahmed Iqbal.; Allen, J.; Bhagwan, B.; Moodley, A. A.; Mthiyane, T. (The Infectious Diseases Society of America., 2003)
      Multidrug-resistant (MDR) pulmonary tuberculosis (TB) is well described in the literature. Reports of MDR TB meningitis (MDR-TBM), however, are limited to case reports and a single case series. During the period of 1999-2002, ...
    • Population pharmacokinetics and pharmacodynamics of Ofloxacin in South African patients with multidrug-resistant tuberculosis. 

      Chigusta, Emmanuel.; Meredith, Sandra.; Wiesner, Lubbe.; Padayatchi, Nesri.; Harding, Joe.; Moodley, Prashini.; Mac Kenzie, William R.; Weiner, Marc.; Mcilleron, Helen.; Kirkpatrick, Carl M. J. (American Society for Microbiology., 2012-07)
      Despite the important role of fluoroquinolones and the predominant use of ofloxacin for treating multidrug-resistant tuberculosis in South Africa, there are limited data on ofloxacin pharmacokinetics in patients with ...
    • Pregnancies complicated by multidrug-resistant tuberculosis and HIV co-infection in Durban, South Africa. 

      Khan, Munira.; Moodley, Jagidesa.; Pillay, T.; Ramjee, A.; Padayatchi, Nesri. (International Union against Tuberculosis and Lung Disease., 2007)
      SETTING: Tertiary hospitals in KwaZulu Natal, South Africa. OBJECTIVE: To study the impact of multidrug-resistant tuberculosis (MDR-TB) and human immunodeficiency virus-1 (HIV-1) co-infection during pregnancy on maternal ...
    • Pulmonary resection for extensively drug resistant tuberculosis in KwaZulu-Natal, South Africa. 

      Iddriss, Adam.; Padayatchi, Nesri.; Reddy, Darshan.; Reddi, Anu. (Elsevier., 2012-08)
      Background—Extensively-drug resistant tuberculosis (XDR-TB) has been reported in 58 countries around the world and has emerged as a major public health challenge. This is the first report to describe pulmonary resection ...
    • A review of progress on HIV, AIDS and Tuberculosis. 

      Padayatchi, Nesri.; Naidoo, Kogieleum.; Dawood, Halima.; Kharsany, Ayesha B. M.; Abdool Karim, Quarraisha. (2010)
      As a United Nations member state, South Africa is signatory to the Millennium Declaration and is committed to achieve the Millennium Development Goals (MDGs) and targets for 2015. This chapter provides an overview ...
    • The SAPIT trial provides essential evidence on risks and benefits of integrated and sequential treatment of HIV and tuberculosis. 

      Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Baxter, Cheryl.; Friedland, Gerald H.; Gengiah, Tanuja N.; Gray, Andrew L.; Grobler, Anneke.; Naidoo, Kogieleum.; Padayatchi, Nesri.; El-Sadr, Wafaa. (Health and Medical Publications Group., 2010-12)
      Boulle et al.(1) queried whether a clinical trial was needed to provide the evidence for the mortality benefits of antiretroviral therapy (ART) initiation during tuberculosis (TB) treatment. While several experts, including ...
    • Social constraints to TB/HIV healthcare: accounts from coinfected patients in South Africa. 

      Daftary, Amrita.; Padayatchi, Nesri. (Routledge., 2011)
      There is a growing imperative to improve the coordination and collaboration of tuberculosis (TB) and HIV healthcare services in response to escalating rates of TB/HIV coinfection. Patient-specific challenges associated ...
    • Substitution of Moxifloxacin for Isoniazid during intensive phase treatment of Pulmonary Tuberculosis. 

      Dorman, Susan E.; Johnson, John L.; Goldberg, Stefan.; Muzanye, Grace.; Padayatchi, Nesri.; Bozeman, Lorna.; Heilig, Charles M.; Bernardo, John.; Choudhri, Shurjeel.; Grosset, Jacques H.; Guy, Elizabeth.; Guyadeen, Priya.; Leus, Maria Corazon.; Maltas, Gina.; Menzies, Dick.; Nuermberger, Eric L.; Villarino, Margarita.; Vernon, Andrew.; Chaisson, Richard E. (American Thoracic Society., 2009-08-01)
      Rationale: Moxifloxacin has potent activity against Mycobacterium tuberculosis in vitro and in a mouse model of antituberculosis (TB) chemotherapy, but data regarding its activity in humans are limited. Objectives: Our ...