Now showing items 1-5 of 5

    • Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. 

      Archary, Derseree.; Rong, Rong.; Gordon, Michelle Lucille.; Boliar, Saikat.; Madiga, Maphuti C.; Gray, Elin S.; Dugast, Anne-Sophie.; Hermanus, Tandile.; Goulder, Philip.; Coovadia, Hoosen Mahomed.; Werner, Lise.; Morris, Lynn.; Alter, Galit.; Derdeyn, Cynthia A.; Ndung'u, Thumbi. (Elsevier., 2012-11-25)
      Neutralizing (nAbs) and high affinity binding antibodies may be critical for an efficacious HIV-1 vaccine. We characterized virus-specific nAbs and binding antibody responses over 21 months in eight HIV-1 subtype C chronically ...
    • Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization. 

      Georgiev, Ivelin S.; Doria-Rose, Nicole A.; Zhou, Tongqing.; Do Kwon, Young.; Staupe, Ryan P.; Moquin, Stephanie.; Chuang, Gwo-Yu.; Louder, Mark K.; Schmidt, Stefan D.; Altae-Tran, Han R.; Bailer, Robert T.; McKee, Krisha.; Nason, Martha.; O'Dell, Sijy.; Ofek, Gilad.; Pancera, Marie.; Srivatsan, Sanjay.; Shapiro, Lawrence.; Connors, Mark.; Migueles, Stephen A.; Morris, Lynn.; Nishimura, Yoshiaki.; Martin, Malcolm A.; Mascola, John R.; Kwong, Peter D. (American Association for the Advancement of Science., 2013-05-10)
      Serum characterization and antibody isolation are transforming our understanding of the humoral immune response to viral infection. Here, we show that epitope specificities of HIV-1–neutralizing antibodies in serum can be ...
    • High titer HIV-1 V3-specific antibodies with broad reactivity but low neutralizing potency in acute infection and following vaccination. 

      Davis, Katie L.; Gray, Elin S.; Moore, Penny L.; Decker, Julie M.; Salomon, Aidy.; Montefiori, David C.; Graham, Barney S.; Keefer, Michael C.; Pinter, Abraham.; Morris, Lynn.; Hahn, Beatrice H.; Shaw, George M. (Elsevier, 2009-03)
      Identifying the earliest neutralizing antibody specificities that are elicited following infection or vaccination by HIV-1 is an important objective of current HIV/AIDS vaccine research. We have shown previously ...
    • Multiple pathways of escape from HIV broadly cross-neutralizing V2-dependent antibodies. 

      Moore, Penny L.; Sheward, Daniel.; Nonyane, Molati.; Ranchobe, Nthabeleng.; Hermanus, Tandile.; Gray, Elin S.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn.; Morris, Lynn. (American Society for Microbiology., 2013-02-13)
      Broadly cross-neutralizing (BCN) antibodies are likely to be critical for an effective HIV vaccine. However, the ontogeny of such antibodies and their relationship with autologous viral evolution is unclear. Here, we ...
    • Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes. 

      Wibmer, Constantinos Kurt.; Bhiman, Jinal N.; Gray, Elin S.; Tumba, Nancy L.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn.; Morris, Lynn.; Moore, Penny L. (Plos., 2013-10-31)
      Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how these antibodies develop remain important goals in the quest to rationally develop an HIV-1 vaccine. We previously identified a ...