Now showing items 1-2 of 2

    • Identification of broadly neutralizing antibody epitopes in 1 the HIV-1 envelope glycoprotein using evolutionary models. 

      Lacerda, Miguel.; Moore, Penny L.; Ngandu, Nobubelo K.; Seaman, Michael.; Gray, Elin S.; Murrell, Ben.; Krishnamoorthy, Mohan.; Nonyane, Molati.; Madiga, Maphuti.; Wibmer, Constantinos Kurt.; Sheward, Daniel.; Bailer, Robert T.; Gao, Hongmei.; Greene, Kelli M.; Abdool Karim, Salim Safurdeen.; Mascola, John R.; Korber, Bette TM.; Montefiori, David C.; Morris, Lynn.; Williamson, Carolyn.; Seoighe, Cathal. (Virology Journal, 2013)
      Background: Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine. Methods: We have developed a computational ...
    • Structure discovery in hidden Markov models. 

      Murrell, Ben. (2009)
      The Baum-Welch algorithm for training hidden Markov models (HMMs) requires model topology and initial parameters to be specifed, and iteratively improves the model parameters. Sometimes prior knowledge of the process being ...