Now showing items 1-20 of 111

    • Achieving the health Millennium Development Goals for South Africa : challenges and priorities. 

      Chopra, Mickey.; Lawn, Joy E.; Sanders, David.; Barron, Peter.; Abdool Karim, Salim Safurdeen.; Bradshaw, Debbie.; Jewkes, Rachel.; Abdool Karim, Quarraisha.; Flisher, Alan J.; Mayosi, Bongani M.; Tollman, Stephen M.; Churchyard, Gavin J.; Coovadia, Hoosen Mahomed. (Elsevier., 2009-09-19)
      15 years after liberation from apartheid, South Africans are facing new challenges for which the highest calibre of leadership, vision, and commitment is needed. The effect of the unprecedented HIV/AIDS epidemic has been ...
    • Adaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure. 

      Treurnicht, Florette K.; Seoighe, Cathal.; Martin, Darren P.; Wood, N.; Abrahams, Melissa-Rose.; de Assis Rosa, Debra.; Bredell, H.; Woodman, Zenda.; Hide, Winston.; Mlisana, Koleka Patience.; Abdool Karim, Salim Safurdeen.; Gray, Clive M.; Williamson, Carolyn. (Elsevier., 2009)
      It is unresolved whether recently transmitted human immunodeficiency viruses (HIV) have genetic features that specifically favour their transmissibility. To identify potential “transmission signatures”, we compared 20 ...
    • An adaptive design to bridge the gap between phase 2b/3 microbicide effectiveness trials and evidence required for licensure. 

      Taylor, Douglas.; Grobler, Anna Christina.; Abdool Karim, Salim Safurdeen. (Sage., 2012-05-18)
      Background. Vaginally and rectally applied microbicides are being developed to help prevent sexual acquisition of HIV. Due to the lack of surrogate outcomes, the path toward licensure typically moves directly from expanded ...
    • An AIDS-Free Generation? 

      Abdool Karim, Salim Safurdeen. (American Association for the Advancement of Science., 2012-07-13)
      No abstract available.
    • Anaemia in acute HIV-1 Subtype C infection. 

      Mlisana, Koleka Patience.; Auld, Sara C.; Grobler, Anna Christina.; Van Loggerenberg, Francois.; Williamson, Carolyn.; Iriogbe, Itua.; Sobieszczyk, Magdalena E.; Abdool Karim, Salim Safurdeen. (Plos., 2008-02)
      Background: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin ...
    • Antiretroviral prophylaxis for HIV prevention reaches a key milestone. 

      Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha. (Elsevier., 2012-06-02)
      No abstract available.
    • Antiretroviral prophylaxis: a defining moment in HIV control. 

      Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha. (Elsevier., 2011)
      No abstract available.
    • Antiretroviral therapy : challenges and options in South Africa. 

      Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Baxter, Cheryl. (Elsevier., 2003-11-01)
      No abstract available.
    • APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4R T-cell counts and plasma viral load. 

      Reddy, Kavidha.; Winkler, Cheryl A.; Werner, Lise.; Mlisana, Koleka Patience.; Abdool Karim, Salim Safurdeen.; Ndung'u, Thumbi. (Lippincott Williams & Wilkins., 2008)
      Objectives: In the absence of HIV-1 virion infectivity factor (Vif), cellular cytosine deaminases such as apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) inhibit the virus by inducing ...
    • Association of HIV-Specific and Total CD8+ T Memory Phenotypes in Subtype C HIV-1 Infection with Viral Set Point. 

      Burgers, Wendy A.; Riou, Catherine.; Mlotshwa, Mandla.; Maenetje, Pholo.; de Assis Rosa, Debra.; Brenchley, Jason.; Mlisana, Koleka Patience.; Douek, Daniel C.; Koup, Richard.; Roederer, Mario.; De Bruyn, Guy.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn.; Gray, Clive M. (The American Association of Immunologists, Inc., 2009)
      Understanding early immunological events during HIV-1 infection that may set the course of disease progression is important for identifying correlates of viral control. This study explores the association of differentiation ...
    • Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression. 

      Madlala, Paradise Z.; Gijsbers, Rik.; Christ, Frauke.; Hombrouck, Anneleen.; Werner, Lise.; Mlisana, Koleka Patience.; An, Ping.; Abdool Karim, Salim Safurdeen.; Winkler, Cheryl A.; Debyser, Zeger.; Ndung'u, Thumbi. (Lippincott Williams & Wilkins., 2011-06-10)
      Objective: LEDGF/p75, encoded by the PSIP1 gene, interacts with HIV-1 integrase and targets HIV-1 integration into active genes. We investigated the influence of polymorphisms in PSIP1 on HIV-1 acquisition and disease ...
    • Association of TRIM22 with the Type 1 Interferon Response and Viral Control during Primary HIV-1 Infection. 

      Singh, Ravesh.; Gaiha, Gaurav.; Werner, Lise.; Mlisana, Koleka Patience.; Luban, Jeremy.; Walker, Bruce D.; Abdool Karim, Salim Safurdeen.; Ndung'u, Thumbi.; Brass, Abraham.; McKim, Kevin. (American Society for Microbiology., 2011-01)
      Type 1 interferons (IFNs) induce the expression of the tripartite interaction motif (TRIM) family of E3 ligases, but the contribution of these antiviral factors to HIV pathogenesis is not completely understood. We hypothesized ...
    • Bacterial vaginosis and the risk of trichomonas vaginalis acquisition among HIV-1 negative women. 

      Balkus, Jennifer E.; Richardson, Barbra A.; Rabe, Lorna K.; Taha, Taha E.; Mgodi, Nyaradzo.; Kasaro, Margaret Phiri.; Ramjee, Gita.; Hoffman, Irving F.; Abdool Karim, Salim Safurdeen. (American Sexually Transmitted Diseases Association., 2014)
      Background: The vaginal microbiota may play a role in mediating susceptibility to sexually transmitted infections, including Trichomonas vaginalis (TV). Methods: Data were analyzed from HIV-1-seronegative women ...
    • Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external region. 

      Gray, Elin S.; Madiga, Maphuti C.; Moore, Penny L.; Mlisana, Koleka Patience.; Abdool Karim, Salim Safurdeen.; Binley, James M.; Shaw, George M.; Mascola, John R.; Morris, Lynn. (American Society for Microbiology., 2009-11)
      We identified three cross-neutralizing plasma samples with high-titer anti-membrane proximal external region (MPER) peptide binding antibodies from among 156 chronically human immunodeficiency virus type 1-infected ...
    • The C3-V4 region is a major target of autologous neutralizing antibodies in human immunodeficiency virus type 1 subtype C Infection. 

      Moore, Penny L.; Gray, Elin S.; Choge, Isaac A.; Ranchobe, Nthabeleng.; Mlisana, Koleka Patience.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn.; Morris, Lynn. (American Society for Microbiology., 2008)
      The early autologous neutralizing antibody response in human immunodeficiency virus type 1 (HIV-1) subtype C infections is often characterized by high titers, but the response is type specific with little to no cross-neutralizing ...
    • CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck. 

      Valley-Omar, Ziyaad.; Sibeko, Sengeziwe.; Anderson, Jeffrey A.; Goodier, Sarah A.; Werner, Lise.; Arney, Leslie.; Naranbhai, Vivek.; Treurnicht, Florette K.; Abrahams, Melissa-Rose.; Bandawe, Gama.; Swanstrom, Ronald.; Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Williamson, Carolyn. (Oxford University Press., 2011)
      Alterations of the genital mucosal barrier may influence the number of viruses transmitted from a human immunodeficiency virus–infected source host to the newly infected individual. We used heteroduplex tracking assay and ...
    • Challenges in HIV-prevention microbicide research. 

      Harrison, Polly.; Mellors, John W.; Richardson, Barbra A.; Masse, Benoıt.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Cates, Ward.; Coletti, Anne.; Derbyshire, Janet.; Dorflinger, Laneta J.; Feldblum, Paul.; Gabelnick, Henry.; Halpern, Vera Grigorieva.; Jespers, Vicky.; Kharsany, Ayesha B. M.; McCormack, Sheena.; Nunn, Andrew.; McGowan, Ian.; Omar, Rabeea F.; Padian, Nancy S.; Pedneault, Louise.; Robbiani, Melissa Pope.; Sailer, James.; Taylor, Douglas.; Tolley, Elizabeth E.; Van Damme, Lut.; Vermund, Sten H.; Van de Wijgert, Janneke. (American Association for the Advancement of Science., 2008-12-17)
      No abstract available.
    • Challenging racial stereotyping of AIDS in South Africa with prevalence of HIV in pregnant women. 

      Dilraj, Athmanundh.; Abdool Karim, Salim Safurdeen.; Pillay, Sally. (South African Medical Association / Health & Medical Publications Group., 2007)
      No abstract available.
    • Changes in natural killer cell activation and function during primary HIV-1 infection. 

      Naranbhai, Vivek.; Altfeld, Marcus.; Abdool Karim, Salim Safurdeen.; Ndung'u, Thumbi.; Abdool Karim, Quarraisha.; Carr, William Henry. (Plos., 2013-01-09)
      Background. Recent reports suggest that Natural Killer (NK) cells may modulate pathogenesis of primary HIV-1 infection. However, HIV dysregulates NK-cell responses. We dissected this bi-directional relationship to understand ...
    • Changes to antiretroviral drug regimens during integrated TB-HIV treatment: results of the SAPiT trial. 

      Naidoo, Anushka.; Naidoo, Kogieleum.; Yende-Zuma, Nonhlanhla.; Gengiah, Tanuja N.; Padayatchi, Nesri.; Gray, Andrew L.; Bamber, Sheila.; Nair, Gonasagrie.; Abdool Karim, Salim Safurdeen. (International Medical Press., 2014)
      Background—Frequency of drug changes in combination antiretroviral therapy among patients starting both tuberculosis (TB) and human immunodeficiency virus (HIV) therapy, as a result of treatment-limiting toxicity or ...