Now showing items 1-20 of 79

    • Achieving the health Millennium Development Goals for South Africa : challenges and priorities. 

      Chopra, Mickey.; Lawn, Joy E.; Sanders, David.; Barron, Peter.; Abdool Karim, Salim Safurdeen.; Bradshaw, Debbie.; Jewkes, Rachel.; Abdool Karim, Quarraisha.; Flisher, Alan J.; Mayosi, Bongani M.; Tollman, Stephen M.; Churchyard, Gavin J.; Coovadia, Hoosen Mahomed. (Elsevier., 2009-09-19)
      15 years after liberation from apartheid, South Africans are facing new challenges for which the highest calibre of leadership, vision, and commitment is needed. The effect of the unprecedented HIV/AIDS epidemic has been ...
    • Adolescents and HIV clinical trials: ethics, culture, and context. 

      MacQueen, Kathleen M.; Abdool Karim, Quarraisha. (Elsevier., 2007)
      One quarter of HIV infections globally occur among young people 15-24 years of age and more than half of all new infections are to people younger than 25 years. Clearly, there is a need to identify and implement effective ...
    • Antiretroviral prophylaxis for HIV prevention reaches a key milestone. 

      Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha. (Elsevier., 2012-06-02)
      No abstract available.
    • Antiretroviral prophylaxis: a defining moment in HIV control. 

      Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha. (Elsevier., 2011)
      No abstract available.
    • Antiretroviral therapy : challenges and options in South Africa. 

      Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Baxter, Cheryl. (Elsevier., 2003-11-01)
      No abstract available.
    • CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck. 

      Valley-Omar, Ziyaad.; Sibeko, Sengeziwe.; Anderson, Jeffrey A.; Goodier, Sarah A.; Werner, Lise.; Arney, Leslie.; Naranbhai, Vivek.; Treurnicht, Florette K.; Abrahams, Melissa-Rose.; Bandawe, Gama.; Swanstrom, Ronald.; Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Williamson, Carolyn. (Oxford University Press., 2011)
      Alterations of the genital mucosal barrier may influence the number of viruses transmitted from a human immunodeficiency virus–infected source host to the newly infected individual. We used heteroduplex tracking assay and ...
    • Case 15-2011: A 19-year-old South African woman with headache, fatigue, and vaginal discharge. 

      Venter, W. D. Francois.; Ndung'u, Thumbi.; Abdool Karim, Quarraisha. (Massachusetts Medical Society., 2011-05-19)
      No abstract available.
    • Challenges in HIV-prevention microbicide research. 

      Harrison, Polly.; Mellors, John W.; Richardson, Barbra A.; Masse, Benoıt.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Cates, Ward.; Coletti, Anne.; Derbyshire, Janet.; Dorflinger, Laneta J.; Feldblum, Paul.; Gabelnick, Henry.; Halpern, Vera Grigorieva.; Jespers, Vicky.; Kharsany, Ayesha B. M.; McCormack, Sheena.; Nunn, Andrew.; McGowan, Ian.; Omar, Rabeea F.; Padian, Nancy S.; Pedneault, Louise.; Robbiani, Melissa Pope.; Sailer, James.; Taylor, Douglas.; Tolley, Elizabeth E.; Van Damme, Lut.; Vermund, Sten H.; Van de Wijgert, Janneke. (American Association for the Advancement of Science., 2008-12-17)
      No abstract available.
    • Changes in natural killer cell activation and function during primary HIV-1 infection. 

      Naranbhai, Vivek.; Altfeld, Marcus.; Abdool Karim, Salim Safurdeen.; Ndung'u, Thumbi.; Abdool Karim, Quarraisha.; Carr, William Henry. (Plos., 2013-01-09)
      Background. Recent reports suggest that Natural Killer (NK) cells may modulate pathogenesis of primary HIV-1 infection. However, HIV dysregulates NK-cell responses. We dissected this bi-directional relationship to understand ...
    • The changing epidemiology of HIV in 2013. 

      Beyrer, Chris.; Abdool Karim, Quarraisha. (Lippincott Williams & Wilkins., 2013-07)
      Purpose of review. We sought to review the recent epidemiology of HIV-1 and to identify emerging challenges in HIV surveillance and epidemic control. Recent findings. There is increasing evidence that HIV epidemics are ...
    • Co-enrollment in multiple HIV prevention trials - experiences from the CAPRISA 004 Tenofovir gel trial. 

      Abdool Karim, Quarraisha.; Kharsany, Ayesha B. M.; Naidoo, Kasavan.; Yende Zuma, Nonhlanhla.; Gengiah, Tanuja N.; Omar, Zaheen.; Arulappan, Natasha.; Mlisana, Koleka Patience.; Luthuli, Londiwe R.; Abdool Karim, Salim Safurdeen. (Elsevier., 2011-05)
      Background—In settings where multiple HIV prevention trials are conducted in close proximity, trial participants may attempt to enroll in more than one trial simultaneously. Co-enrollment impacts on participant’s safety ...
    • Contraceptive choices, pregnancy rates, and outcomes in a microbicide trial. 

      Sibeko, Sengeziwe.; Baxter, Cheryl.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Yende Zuma, Nonhlanhla. (Lippincott Williams & Wilkins., 2011)
      OBJECTIVE: Women who become pregnant during the conduct of biomedical human immunodeficiency virus prevention trials are taken off the study product for safety reasons. High pregnancy rates can compromise statistical ...
    • Development of methods for cross-sectional HIV incidence estimation in a large, community randomized trial. 

      Laeyendecker, Oliver.; Kulich, Michal.; Donnell, Deborah.; Koma´rek, Arnosˇt.; Omelka, Marek.; Mullis, Caroline E.; Szekeres, Greg.; Piwowar-Manning, Estelle.; Fiamma, Agnes.; Gray, Ronald H.; Lutalo, Tom.; Morrison, Charles S.; Salata, Robert A.; Chipato, Tsungai.; Celum, Connie.; Kahle, Erin M.; Taha, Taha E.; Kumwenda, Newton I.; Abdool Karim, Quarraisha.; Naranbhai, Vivek.; Lingappa, Jairam R.; Sweat, Michael D.; Coates, Thomas.; Eshleman, Susan H. (PLOS ONE., 2013)
      Background: Accurate methods of HIV incidence determination are critically needed to monitor the epidemic and determine the population level impact of prevention trials. One such trial, Project Accept, a Phase III, ...
    • Disclosure of HIV status: experiences of patients enrolled in an integrated TB and HAART programme in South Africa. 

      Gebrekristos, Hirut T.; Lurie, Mark N.; Mthethwa, Nkosinathi.; Abdool Karim, Quarraisha. (NISC & Taylor & Francis, 2009)
      The convergence between the tuberculosis (TB) and HIV epidemics has led to studies investigating strategies for integrated HIV and TB care. We present the experiences of a cohort of 17 patients enrolled in the first ...
    • Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women. 

      Abdool Karim, Salim Safurdeen.; Kashuba, Angela D. M.; Werner, Lise.; Abdool Karim, Quarraisha. (Elsevier., 2011)
      No abstract available.
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. 

      Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Frohlich, Janet A.; Grobler, Anna Christina.; Baxter, Cheryl.; Mansoor, Leila E.; Kharsany, Ayesha B. M.; Sibeko, Sengeziwe.; Mlisana, Koleka Patience.; Omar, Zaheen.; Gengiah, Tanuja N.; Maarschalk, Silvia.; Arulappan, Natasha.; Mlotshwa, Mukelisiwe.; Morris, Lynn.; Taylor, Douglas. (American Association for the Advancement of Science., 2010-09)
      The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed the effectiveness and safety of a 1% vaginal gel formulation of tenofovir, a nucleotide reverse transcriptase inhibitor, for the ...
    • Empowering women in human immunodeficiency virus prevention. 

      Abdool Karim, Quarraisha.; Humphries, Hilton Richard.; Stein, Zena. (Elsevier., 2012-08-01)
      Women comprise one-half of people infected with the human immunodeficiency virus in the world, and about 70% of them live in sub-Saharan Africa. Advancing, untreated HIV disease in women has resulted in substantial declines ...
    • Enrolling adolescents in research on HIV and other sensitive Issues: lessons from South Africa. 

      Singh, Jerome Amir.; Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Mlisana, Koleka Patience.; Williamson, Carolyn.; Gray, Clive M.; Govender, Michele.; Gray, Andrew L. (Plos., 2006-07)
      The article discusses the challenge of enrolling adolescents in HIV studies in South Africa. It is practically impossible in some instances to seek parental consent or to determine who, if anyone, is the legal guardian to ...
    • Epidemiological impact of Tenofovir gel on the HIV epidemic in South Africa. 

      Williams, Brian G.; Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Gouws, Eleanor. (Lippincott Williams & Wilkins., 2011)
      Background: Tenofovir gel, an antiretroviral-based vaginal microbicide, reduced HIV acquisition by 39% in women in a recent randomized controlled clinical trial in South Africa. Methods: To inform policy, we used a dynamical ...
    • Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 Acute Infection Study. 

      Van Loggerenberg, Francois.; Mlisana, Koleka Patience.; Williamson, Carolyn.; Auld, Sara C.; Morris, Lynn.; Gray, Clive M.; Abdool Karim, Quarraisha.; Grobler, Anna Christina.; Barnabas, Nomampondo.; Iriogbe, Itua.; Abdool Karim, Salim Safurdeen. (Plos., 2008)
      Objectives: To describe the baseline demographic data, clinical characteristics and HIV-incidence rates of a cohort at high risk for HIV infection in South Africa as well as the challenges experienced in establishing and ...