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Preservation HIV-1–specific IFNg+ CD4+ T-Cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial.

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dc.contributor.authorMureithi, Marianne W.
dc.contributor.authorPoole, Danielle.
dc.contributor.authorNaranbhai, Vivek.
dc.contributor.authorReddy, Shabashini.
dc.contributor.authorMkhwanazi, Nompumelelo Prudence.
dc.contributor.authorSibeko, Sengeziwe.
dc.contributor.authorWerner, Lise.
dc.contributor.authorAbdool Karim, Quarraisha.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.contributor.authorNdung'u, Peter Thumbi.
dc.contributor.authorAltfeld, Marcus.
dc.date.accessioned2012-11-24T07:09:54Z
dc.date.available2012-11-24T07:09:54Z
dc.date.created2011
dc.date.issued2011
dc.description.abstractAbstract: The Centre for the AIDS Program of Research in South Africa 004 trial demonstrated reduction of sexual HIV-1 acquisition in women using a vaginal microbicide containing tenofovir. A better understanding of the consequences of antiretroviral-containing microbicides for immune responses in individuals with intercurrent HIV-1 infection is needed for future trials combining the use of microbicides with HIV-1 vaccines. Investigation of immune responses in women who acquired HIV-1 although using tenofovir gel showed significantly higher (P = 0.01) Gag-specific IFNγ+ CD4+ T-cell responses. The use of tenofovir-containing gel around the time of infection can modulate HIV-1 immunity, and these immunological changes need to be considered in future trials combining vaccines and microbicides.en
dc.identifier.citationMureithi, M.W. et al. 2012. Preservation HIV-1–specific IFNg+ CD4+ T-Cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial. J Acquir Immune Defic Syndr. 60 (2), pp. 124-127.en
dc.identifier.issn1525-4135
dc.identifier.urihttp://dx.doi.org/10.1097/QAI.0b013e31824f53a9en
dc.identifier.urihttp://hdl.handle.net/10413/7997
dc.language.isoenen
dc.publisherLippincott Williams & Wilkins.en
dc.subjectAIDS vaccines.en
dc.subjectAIDS (Disease)--Vaccination.en
dc.subjectHIV infections--Immunology.en
dc.subjectClinical trials.en
dc.subject.otherTenofovir.en
dc.subject.otherVaginal microbicides.en
dc.subject.otherHIV-1-specific CD4+ T-cell help.en
dc.titlePreservation HIV-1–specific IFNg+ CD4+ T-Cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial.en
dc.typePeer reviewed journal articleen

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